scholarly journals Mast cell heterogeneity and anti-inflammatory annexin A1 expression in leprosy skin lesions

2018 ◽  
Vol 118 ◽  
pp. 277-284
Author(s):  
Maurício B. Costa ◽  
Kallyne K.O. Mimura ◽  
Aline A. Freitas ◽  
Emerith M. Hungria ◽  
Ana Lúcia O.M. Sousa ◽  
...  
Keyword(s):  
Mast Cell ◽  
Skin Lesions ◽  
Annexin A1 ◽  
Cell Heterogeneity ◽  
Anti Inflammatory ◽  
Mast Cell Heterogeneity

Mast cell heterogeneity

1984 ◽  
Vol 62 (6) ◽  
pp. 734-737 ◽  
Author(s):  
F. Shanahan ◽  
J. A. Denburg ◽  
J. Bienenstock ◽  
A. D. Befus
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Regulatory Peptides ◽  
Cell Heterogeneity ◽  
Cell Secretion ◽  
Biochemical Basis ◽  
Mucosal Mast Cells ◽  
Mast Cell Heterogeneity

Increasing evidence for the existence of inter- and intra-species mast cell heterogeneity has expanded the potential biological role of this cell. Early studies suggesting that mast cells at mucosal sites differ morphologically and histochemically from connective tissue mast cells have been confirmed using isolated intestinal mucosal mast cells in the rat and more recently in man. These studies also established that mucosal mast cells are functionally distinct from connective tissue mast cells. Thus, mucosal and connective tissue mast cells differ in their responsiveness to a variety of mast cell secretagogues and antiallergic agents. Speculation about the therapeutic use of antiallergic drugs in disorders involving intestinal mast cells cannot, therefore, be based on extrapolation from studies of their effects on mast cells from other sites. Regulatory mechanisms for mast cell secretion may also be heterogeneous since mucosal mast cells differ from connective tissue mast cells in their response to a variety of physiologically occurring regulatory peptides. The development of techniques to purify isolated mast cell sub-populations will facilitate future analysis of the biochemical basis of the functional heterogeneity of mast cells.

Investigations of Rat Mast Cell Heterogeneity

1987 ◽  
Vol 82 (3-4) ◽  
pp. 256-258 ◽  
Author(s):  
Dean Befus ◽  
Mark Swieter ◽  
Hidekazu Fujimaki ◽  
Tim Lee
Keyword(s):  
Mast Cell ◽  
Cell Heterogeneity ◽  
Mast Cell Heterogeneity

Mast cell heterogeneity

1989 ◽  
Vol 19 (2) ◽  
pp. 143-155 ◽  
Author(s):  
ANNE-MARIE A. IRANI ◽  
L. B. SCHWARTZ
Keyword(s):  
Mast Cell ◽  
Cell Heterogeneity ◽  
Mast Cell Heterogeneity

scholarly journals Immunophenotyping and functional analysis of purified human uterine mast cells

Blood ◽  
1992 ◽  
Vol 79 (3) ◽  
pp. 708-712 ◽  
Author(s):  
CB Guo ◽  
A Kagey-Sobotka ◽  
LM Lichtenstein ◽  
BS Bochner
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Histamine Release ◽  
Umbilical Vein ◽  
Interleukin 1 ◽  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Ionophore A23187 ◽  
Cell Heterogeneity ◽  
Mast Cell Heterogeneity

Abstract Human mast cells have been purified from uterine tissues, and their surface marker profile and function have been evaluated as part of ongoing studies of mast cell heterogeneity. Using a panel of antibodies, purified uterine mast cells (UMC; 81% +/- 7% purity, n = 10) were analyzed by immunofluorescence and flow cytometry for surface expression of various antigens. Consistent with previous analyses of mast cells from other tissues, UMC expressed HLA class I, IgE, c-kit receptor, CD9, CD33, CD43, CD45, and CD54, while CD11a, CD11b, CD14, CD16, CD23, and CD64 were not detected. Unlike other mast cells, UMC expressed CD11c/CD18 (p150,95) and CD32 (Fc gamma RII). Additional antigens not previously studied on mast cells included the selectin LECAM-1 (Leu-8) and several beta 1 and beta 3 integrins; expression of very late activation antigen-4 (VLA-4) (CD49d/CD29), VLA-5 (CD49e/CD29), and the vitronectin receptor (CD51/CD61) was seen. Functional studies showed that treatment of human umbilical vein endothelial cells with interleukin-1 (5 ng/mL for 4 hours) resulted in a twofold to threefold increase in adhesiveness for UMC. Purification procedures did not alter histamine release responses to anti-IgE or the calcium ionophore A23187, and treatment of UMC with an anti-CD32 monoclonal antibody (IV.3) did not induce histamine release or alter anti-IgE-induced release. These data suggest that UMC may possess unique phenotypic characteristics, and support the concept of mast cell heterogeneity.

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?

2018 ◽  
Vol 282 (1) ◽  
pp. 35-46 ◽  
Author(s):  
Barbara Frossi ◽  
Francesca Mion ◽  
Riccardo Sibilano ◽  
Luca Danelli ◽  
Carlo E. M. Pucillo
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Heterogeneity ◽  
New Classification ◽  
Mast Cell Heterogeneity

Carboxypeptidase as a Marker of Mast Cell Heterogeneity in Human Tissues

2006 ◽  
Vol 117 (2) ◽  
pp. S69 ◽  
Author(s):  
M.G. Buckley ◽  
S. He ◽  
Y. He ◽  
S. Goda ◽  
J. Gelnar ◽  
...  
Keyword(s):  
Mast Cell ◽  
Human Tissues ◽  
Cell Heterogeneity ◽  
Mast Cell Heterogeneity
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