Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC

2017 ◽  
Vol 109 ◽  
pp. 49-55 ◽  
Author(s):  
Fengping Jiao ◽  
Lu Long ◽  
Shanlong Ding ◽  
Xiaomeng Xie ◽  
Le Jia ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genome Sequencing ◽  
Complete Genome ◽  
Clinical Analysis ◽  
Complete Genome Sequencing ◽  
B Virus

Characterization of hepatitis B virus mutations in untreated patients co-infected with HIV and HBV based on complete genome sequencing

2012 ◽  
Vol 85 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Pisit Tangkijvanich ◽  
Pattaratida Sa-Nguanmoo ◽  
Anchalee Avihingsanon ◽  
Kiat Ruxrungtham ◽  
Kittiyod Poovorawan ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genome Sequencing ◽  
Complete Genome ◽  
Complete Genome Sequencing ◽  
B Virus

scholarly journals Complete-genome analysis of hepatitis B virus from wild-born chimpanzees in central Africa demonstrates a strain-specific geographical cluster

2007 ◽  
Vol 88 (10) ◽  
pp. 2679-2685 ◽  
Author(s):  
Maria Makuwa ◽  
Sandrine Souquière ◽  
Olivier Bourry ◽  
Pierre Rouquet ◽  
Paul Telfer ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Complete Genome ◽  
Geographical Origin ◽  
Hepatitis B Surface Antigen ◽  
Central Africa ◽  
High Plasma ◽  
B Virus ◽  
Geographical Cluster ◽  
Loads Analysis

In order to determine whether geographical or species clustering accounts for the distribution of hepatitis B virus (HBV) in subspecies of chimpanzees in Africa, four complete chimpanzee HBV (ChHBV) genome sequences were obtained from eight hepatitis B surface antigen-positive wild-born chimpanzees from Cameroon, Republic of Congo and Gabon. The serological profiles of these chimpanzees corresponded to the acute or chronic highly replicative phase of HBV infection, as confirmed by high plasma HBV loads. Analysis of the sequence alignment of 256 aa (S region) from the eight HBV-infected chimpanzees allowed us to determine the HBV amino acid patterns specific to each chimpanzee subspecies and to their geographical origin. Phylogenetic analysis of both the S region and the complete genome confirmed this distinctive clustering of eight novel ChHBV strains within Pan troglodytes. The strong phylogenetic associations of ChHBV sequences with both chimpanzee subspecies and their geographical origin were therefore confirmed.

474 Hepatitis B virus genomic markers for hepatocellular carcinoma on full-genome sequencing of 332 patients

2006 ◽  
Vol 44 ◽  
pp. S176-S177
Author(s):  
J.J.Y. Sung ◽  
S.K.W. Tsui ◽  
C.H. Tse ◽  
E.Y.T. Ng ◽  
K.S. Leung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genome Sequencing ◽  
Full Genome ◽  
Full Genome Sequencing ◽  
B Virus ◽  
Genomic Markers

scholarly journals Characterization of hepatitis B virus genotypes among Yucpa Indians in Venezuela

2001 ◽  
Vol 82 (2) ◽  
pp. 359-365 ◽  
Author(s):  
Tatsunori Nakano ◽  
Ling Lu ◽  
Xiaolei Hu ◽  
Masashi Mizokami ◽  
Etsuro Orito ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Complete Genome ◽  
Deletion Mutants ◽  
Reading Frame ◽  
B Virus ◽  
Virus Genotypes ◽  
Core Reading ◽  
Genotype F

The complete genome sequences of hepatitis B virus (HBV) from 12 HBV-infected Yucpa Indians of Venezuela, a group with highly endemic HBV, were amplified and sequenced. The 12 isolates were closely related to each other, with 98·6–100% nucleotide identity. A phylogenetic tree based on the complete genome indicated clearly that they were genotype F. Three individuals had evidence of infection with two different HBV deletion mutants. In two individuals, a three amino acid deletion was identified just prior to the ‘a’ determinant loop of the S region. A third individual was infected with virus that contained a complete core reading frame and a population that contained a deletion in the middle of the core region. These results indicate that genotype F HBV is present in the Venezuelan Yucpa Amerindians and the complete genome sequence allowed the identification of two unique deletion mutants in a limited set of samples.

scholarly journals Analysis of the complete genome of hepatitis B virus subgenotype C2 isolate NHB17965 from a HBV infected patient

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1023 ◽  
Author(s):  
Modhusudon Shaha ◽  
Palash Kumar Sarker ◽  
Md. Saddam Hossain ◽  
Keshob Chandra Das ◽  
Munira Jahan ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Complete Genome ◽  
Infected Patient ◽  
Surface Proteins ◽  
Wild Type ◽  
Small Surface ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Complete Genome Analysis

The burden of chronic hepatitis B virus (HBV) infections is increasingly detected nowadays. Herein, we report a complete genome of HBV subgenotype C2 (HBV/C2) from a HBV infected patient. Complete genome analysis revealed that the isolated strain was a non-recombinant wild type and had several regular substitutions in the reverse transcriptase domain and small surface proteins of HBV. This study may help clinicians and scientists gain in-depth knowledge on the current substitutions of HBV/C2 genome and to identify potential therapies against HBV infections.

scholarly journals Phylogenetic analysis of complete genome sequences of hepatitis B virus from an Afro-Colombian community: presence of HBV F3/A1 recombinant strain

2012 ◽  
Vol 9 (1) ◽  
Author(s):  
Mónica V Alvarado-Mora ◽  
Camila M Romano ◽  
Michele S Gomes-Gouvêa ◽  
Maria F Gutierrez ◽  
Flair J Carrilho ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Complete Genome ◽  
Recombinant Strain ◽  
Genome Sequences ◽  
B Virus ◽  
Community Presence

A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness

Microbiology ◽  
2000 ◽  
Vol 81 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Lieven Stuyver ◽  
Sija De Gendt ◽  
Caroline Van Geyt ◽  
Fabien Zoulim ◽  
Michael Fried ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Complete Genome ◽  
Core Antigen ◽  
Terminal Part ◽  
Hbv Genotype ◽  
Amino Terminal ◽  
B Virus ◽  
The Us ◽  
Genotype A

The hepatitis B virus (HBV) genotype was determined in a total of 121 plasma samples collected in France and the US from patients chronically infected with HBV. HBV genotype A was predominant in this collection, appearing in 66 samples (54%), while genotypes B, C, D, E and F occurred in 4 (3%), 14 (12%), 23 (19%), 1 (1%) and 0 (0%) of samples, respectively. However, the genotype of a total of 13 (11%) samples (2 from France, 11 from the US) could not be determined with the methodology used. Sequence analysis, and subsequent phylogenetic analysis of the complete genome and the individual open reading frames, showed that the virus isolate from these samples was 3248 bp long and, phylogenetically, did not cluster with any of the known genotypes. This strain was provisionally called HBV genotype G. Virus isolates that were obtained from geographically separated regions like France and the US were closely related to each other. All virus strains analysed contained some characteristic differences when compared to genotype A: a translational stop codon at aa 2 and 28 of the preCore region; a 36 nt (12 aa) insert in the amino-terminal part of the Core antigen (HBcAg); a 2 aa deletion in the carboxy-terminal part of HBcAg; and a 1 aa deletion in the preS1 open reading frame. The deduced amino acid sequence of HBsAg suggests that this newly discovered genotype G strain belongs to serological group adw2.

Complete genome sequence of a hepatitis B virus isolate of genotype D2, subtype adrq+, from Brazil

2017 ◽  
Vol 162 (6) ◽  
pp. 1695-1700 ◽  
Author(s):  
Natália Spitz ◽  
Aline S. Moreira ◽  
Francisco C. A. Mello ◽  
Helena Cristina F. Franz ◽  
Selma A. Gomes ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Virus Isolate ◽  
B Virus
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