Novel reassortant influenza viruses between pandemic (H1N1) 2009 and other influenza viruses pose a risk to public health

2015 ◽  
Vol 89 ◽  
pp. 62-72 ◽  
Author(s):  
Weili Kong ◽  
Feibing Wang ◽  
Bin Dong ◽  
Changbo Ou ◽  
Demei Meng ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 2009

scholarly journals Seroconversion to Pandemic (H1N1) 2009 Virus and Cross-Reactive Immunity to Other Swine Influenza Viruses

2011 ◽  
Vol 17 (10) ◽  
pp. 1897-1899 ◽  
Author(s):  
Ranawaka A.P.M. Perera ◽  
Steven Riley ◽  
Siu K. Ma ◽  
Hua-Chen Zhu ◽  
Yi Guan ◽  
...  
Keyword(s):  
Swine Influenza ◽  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 2009

scholarly journals Full-genome analysis of the pandemic (H1N1) 2009 influenza viruses isolated in Ukraine during 2009-2017 years

2019 ◽  
Vol 79 ◽  
pp. 9
Author(s):  
O. Smutko ◽  
A. Fesenko ◽  
L. Radchenko ◽  
O. Onishchenko ◽  
L. Leibenko ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Full Genome ◽  
Full Genome Analysis ◽  
Pandemic H1n1 2009

scholarly journals Impact of Amino Acid Mutations in PB2, PB1-F2, and NS1 on the Replication and Pathogenicity of Pandemic (H1N1) 2009 Influenza Viruses

2011 ◽  
Vol 85 (9) ◽  
pp. 4596-4601 ◽  
Author(s):  
M. Ozawa ◽  
S. Basnet ◽  
L. M. Burley ◽  
G. Neumann ◽  
M. Hatta ◽  
...  
Keyword(s):  
Amino Acid ◽  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 2009 ◽  
Amino Acid Mutations

Genetic characterization of Thai swine influenza viruses after the introduction of pandemic H1N1 2009

Virus Genes ◽  
2013 ◽  
Vol 47 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Nataya Charoenvisal ◽  
Juthatip Keawcharoen ◽  
Donruethai Sreta ◽  
Supassama Chaiyawong ◽  
Nutthawan Nonthabenjawan ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Swine Influenza ◽  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 2009

scholarly journals Response to pandemic (H1N1) 2009 influenza in Australia - lessons from a State health department perspective

2010 ◽  
Vol 34 (4) ◽  
pp. 477 ◽  
Author(s):  
Tarun S. Weeramanthri ◽  
Andrew G. Robertson ◽  
Gary K. Dowse ◽  
Paul V. Effler ◽  
Muriel G. Leclercq ◽  
...  
Keyword(s):  
Public Health ◽  
Decision Making ◽  
Disease Control ◽  
State Government ◽  
Control Agency ◽  
Expert Advice ◽  
Pandemic H1n1 ◽  
Surge Capacity ◽  
Commonwealth Government ◽  
Pandemic H1n1 2009

This article reviews the lessons that can be learned by the health sector, in particular, and the public sector, more generally, from the governmental response to pandemic (H1N1) 2009 influenza A (pH1N1) in Australia during 2009. It covers the period from the emergence of the epidemic to the release of the vaccine, and describes a range of impacts on the Western Australian health system, the government sector and the community. There are three main themes considered from a State government agency perspective: how decisions were influenced by prior planning; how the decision making and communication processes were intimately linked; and the interdependent roles of States and the Commonwealth Government in national programs. We conclude that: (a) communications were generally effective, but need to be improved and better coordinated between the Australian Government, States and general practice; (b) decision making was appropriately flexible, but there needs to be better alignment with expert advice, and consideration of the need for a national disease control agency in Australia; and (c) national funding arrangements need to fit with the model of state-based service delivery and to support critical workforce needs for surge capacity, as well as stockpile and infrastructure requirements. What is known about the topic? There have been a number of articles on pandemic (H1N1) 2009 influenza in Australia that have provided an overview of the response from a Commonwealth Government perspective, as well as specific aspects of the State response (e.g. virology, impact on intensive care units across Australia, infection control). Victoria, Queensland and NSW have published papers more focussed on epidemiology and an overview of public health actions. What does this paper add? This would be the first in-depth account of the response that both details a broader range of impacts and costs across health and other State government agencies, and also provides a critical reflection on governance, communication and decision making arrangements from the beginning of the pandemic to the start of the vaccination program. What are the implications for practitioners? Practitioners (clinical, public health, and laboratory) would recognise the importance of the workforce and surge capacity issues highlighted in the paper, and the extent to which they were stretched. Addressing these issues is vital to meeting practitioner needs in future pandemic seasons. Policy makers would see the relevance of the observations and analysis to governance arrangements within a Federal system, where the majority of funding is provided from the Commonwealth level, whereas service delivery responsibilities remain with the States and Territories. In particular, the argument to consider a national disease control agency along the lines of the US and UK will be of interest to public health and communicable disease practitioners in all States and Territories, as it would affect how and where policy and expert advice is created and used.

Isolation and complete genomic characterization of pandemic H1N1/2009 influenza viruses from Cuban swine herds

2013 ◽  
Vol 94 (3) ◽  
pp. 781-788 ◽  
Author(s):  
Lester Josué Pérez ◽  
Carmen Laura Perera ◽  
Armando Vega ◽  
Maria T. Frías ◽  
Dagmar Rouseaux ◽  
...  
Keyword(s):  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Genomic Characterization ◽  
Pandemic H1n1 2009 ◽  
Swine Herds ◽  
Complete Genomic

scholarly journals Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009–2011

Virus Genes ◽  
2013 ◽  
Vol 47 (3) ◽  
pp. 456-466 ◽  
Author(s):  
Irona Khandaker ◽  
Akira Suzuki ◽  
Taro Kamigaki ◽  
Kentaro Tohma ◽  
Takashi Odagiri ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Influenza Viruses ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 2009

scholarly journals Rapid Detection of Reassortment of Pandemic H1N1/2009 Influenza Virus

2010 ◽  
Vol 56 (8) ◽  
pp. 1340-1344 ◽  
Author(s):  
Leo L M Poon ◽  
Polly W Y Mak ◽  
Olive T W Li ◽  
Kwok Hung Chan ◽  
Chung Lam Cheung ◽  
...  
Keyword(s):  
Gene Segment ◽  
Swine Influenza ◽  
Influenza Viruses ◽  
Screening Tools ◽  
Influenza Surveillance ◽  
Surveillance Program ◽  
Pandemic H1n1 ◽  
Rt Pcr ◽  
Pandemic H1n1 2009 ◽  
Ongoing Surveillance

BACKGROUND Influenza viruses can generate novel reassortants in coinfected cells. The global circulation and occasional introductions of pandemic H1N1/2009 virus in humans and in pigs, respectively, may allow this virus to reassort with other influenza viruses. These possible reassortment events might alter virulence and/or transmissibility of the new reassortants. Investigations to detect such possible reassortants should be included as a part of pandemic influenza surveillance plans. METHODS We established a real-time reverse-transcription (RT)-PCR–based strategy for the detection of reassortment of pandemic H1N1/2009 virus. Singleplex SYBR green–based RT-PCR assays specific for each gene segment of pandemic H1N1/2009 were developed. These assays were evaluated with influenza viruses of various genetic backgrounds. RESULTS All human pandemic H1N1 (n = 27) and all seasonal human (n = 58) isolates were positive and negative, respectively, for all 8 segments. Of 48 swine influenza viruses isolated from our ongoing surveillance program of influenza viruses in swine, 10 were positive in all reactions. All 8 viral segments of these 10 samples were confirmed to be of pandemic H1N1 origin, indicating that these were caused by zoonotic transmissions from human to pigs. The 38 swine viruses that were nonpandemic H1N1/2009 had 1–6 gene segments positive in the tests. Further characterization of these nonpandemic H1N1/2009 swine viruses indicated that these PCR-positive genes were the precursor genes of the pandemic H1N1/2009 virus. CONCLUSIONS Our results demonstrated that these assays can detect reintroductions of pandemic H1N1/2009 virus in pigs. These assays might be useful screening tools for identifying viral reassortants derived from pandemic H1N1/2009 or its precursors.

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