A polymorphism in a staphylococcal enterotoxin receptor gene (T cell receptor BV3 recombination signal sequence) is not associated with unexplained sudden unexpected death in infancy in an Australian cohort

2010 ◽  
Vol 49 (1-2) ◽  
pp. 51-53 ◽  
Author(s):  
Amanda R. Highet ◽  
Catherine S. Gibson ◽  
Paul N. Goldwater
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Signal Sequence ◽  
Receptor Gene ◽  
Cell Receptor ◽  
Sudden Unexpected Death ◽  
Recombination Signal Sequence ◽  
Unexpected Death ◽  
Recombination Signal ◽  
Australian Cohort

scholarly journals T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells.

1996 ◽  
Vol 16 (2) ◽  
pp. 609-618 ◽  
Author(s):  
F Livak ◽  
D G Schatz
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Signal Sequence ◽  
Cell Receptor ◽  
Recombination Reaction ◽  
Dna Molecules ◽  
Coding Region ◽  
Recombination Signal ◽  
By Products

In addition to the assembled coding regions of immunoglobulin and T-cell receptor (TCR) genes, the V(D)J recombination reaction can in principle generate three types of by-products in normal developing lymphocytes: broken DNA molecules that terminate in a recombination signal sequence or a coding region (termed signal or coding end molecules, respectively) and DNA molecules containing fused recombination signal sequences (termed reciprocal products). Using a quantitative Southern blot analysis of the murine TCR alpha locus, we demonstrate that substantial amounts of signal end molecules and reciprocal products, but not coding end molecules, exist in thymocytes, while peripheral T cells contain substantial amounts of reciprocal products. At the 5' end of the J alpha locus, 20% of thymus DNA exists as signal end molecules. An additional 30 to 40% of the TCR alpha/delta locus exists as remarkably stable reciprocal products throughout T-cell development, with the consequence that the TCR C delta region is substantially retained in alpha beta committed T cells. The disappearance of the broken DNA molecules occurs in the same developmental transition as termination of expression of the recombination activating genes, RAG-1 and RAG-2. These findings raise important questions concerning the mechanism of V(D)J recombination and the maintenance of genome integrity during lymphoid development.

The other T-cell receptor gene

Science ◽  
1984 ◽  
Vol 225 (4658) ◽  
pp. 155-155
Author(s):  
J. Marx
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Receptor Gene ◽  
Cell Receptor ◽  
The Other ◽  
T Cell Receptor Gene ◽  
Cell Receptor Gene
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