Differential susceptibility of Sprague–Dawley and Fischer 344 rats to infection by Francisella tularensis

2009 ◽  
Vol 46 (4) ◽  
pp. 231-234 ◽  
Author(s):  
Claudine R. Raymond ◽  
J. Wayne Conlan
Keyword(s):  
Francisella Tularensis ◽  
Differential Susceptibility ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344

[3H](+)-7-OH-DPAT and [3H]pramipexole binding in the striatum and nucleus accumbens of Sprague-Dawley and Fischer-344 rats

Life Sciences ◽  
1998 ◽  
Vol 63 (19) ◽  
pp. PL275-PL280 ◽  
Author(s):  
David R. Wallace ◽  
Jeannie Owens ◽  
Rosemarie M. Booze
Keyword(s):  
Nucleus Accumbens ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344

Glucose-induced insulin secretion by perfused pancreas of 2- and 12-mo-old Fischer 344 rats

1984 ◽  
Vol 247 (3) ◽  
pp. E385-E388
Author(s):  
D. L. Curry ◽  
G. Reaven ◽  
E. Reaven
Keyword(s):  
Insulin Secretion ◽  
Islet Cell ◽  
Cell Mass ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344 ◽  
Sprague Dawley Rats ◽  
Glucose Challenge ◽  
Species Specific ◽  
Beta Cell Response

Previous studies have shown that cells from older Sprague-Dawley rats secrete insulin less efficiently in response to a maximal glucose challenge than do beta-cells from young animals. In the current study we have asked whether this change in beta-cell response occurs in another strain of rat, and, if so, whether the secretory defect occurs at submaximal as well as maximal glucose stimulatory levels. Pancreas perfusions were carried out on 2- and 12-mo-old Fischer 344 rats at perfusate glucose concentrations of 150 and 300 mg/dl. The secretory data for each pancreas was subsequently corrected for differences in islet cell mass and expressed as insulin secretion per unit islet cell. The results show that 12-mo-old Fischer rats release more insulin per total pancreas than do 2-mo-old animals at both glucose concentrations. However when corrected for islet cell mass, the amount of insulin secretion per islet cell is actually reduced in the older Fischer rat. These data are comparable to those seen previously in the 12-mo-old Sprague-Dawley rat and indicate that the insulin secretory defect seen as rats grow older is not species specific.

Acute Nephrotoxicity of Isomeric N-(Dichlorophenyl)succinimides in Sprague-Dawley and Fischer 344 Rats

1985 ◽  
Vol 5 (6part1) ◽  
pp. 1119-1127
Author(s):  
DAVID J. YANG ◽  
E. PATRICIA LAHODA ◽  
PATRICK I. BROWNE ◽  
GARY O. RANKIN
Keyword(s):  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344

Structure-nephrotoxicity relationships for para-substitutedN-phenylsuccinimides in Sprague-Dawley and Fischer 344 rats

Toxicology ◽  
1985 ◽  
Vol 36 (1) ◽  
pp. 23-35 ◽  
Author(s):  
David J. Yang ◽  
E. Patricia Lahoda ◽  
Patrick I. Brown ◽  
Gary O. Rankin
Keyword(s):  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344

Metabolic responses to tyramine and cold in young male Sprague-Dawley and Fischer 344 rats

1984 ◽  
Vol 246 (2) ◽  
pp. E141-E144 ◽  
Author(s):  
M. Kiang-Ulrich ◽  
S. M. Horvath
Keyword(s):  
Young Male ◽  
Strain Differences ◽  
Metabolic Responses ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
O2 Uptake ◽  
Fischer 344 ◽  
Cold Challenge ◽  
Colonic Temperature ◽  
F344 Rats

Significant differences in responses to intraperitoneally injected tyramine or cold exposure (-10 degrees C) were observed in young (3-4 mo) male Sprague-Dawley (S-D) and Fischer 344 (F344) rats cold-acclimated (CA) or non-cold-acclimated (non-CA). Non-CA S-D and F344 rats respond to tyramine by increased O2 uptake and elevation of colonic temperature, but, as we had reported previously, the optimal doses of tyramine required was significantly different for these two strains, i.e., 2 mg/kg for F344 vs. 20 mg/kg for S-D. The response to tyramine was significantly potentiated by cold acclimation in both strains of rats. Despite the different dosages of tyramine given to the animals, similar increases in O2 uptakes and colonic temperatures were observed. Differences between these two strains were also evident in their responses to a cold challenge (3 h, -10 degrees C). The ranking for cold tolerance (-10 degrees C) was as follows: CA F344 greater than non-CA F344 greater than CA S-D greater than non-CA S-D. These differences between the two strains suggest that interpretations regarding the response of rats to stressful conditions must be made with caution and appreciation of strain differences.

Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague‐Dawley and Fischer 344 rats

1994 ◽  
Vol 43 (2) ◽  
pp. 169-182 ◽  
Author(s):  
Lawrence T. Wetzel ◽  
Louis G. Luempert ◽  
Charles B. Breckenridge ◽  
Merrill O. Tisdel ◽  
James T. Stevens ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Tumor Formation ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344 ◽  
Chronic Effects
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