Orientia tsutsugamushi inhibits tumor necrosis factor α production by inducing interleukin 10 secretion in murine macrophages

2006 ◽  
Vol 40 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Mi-Jeong Kim ◽  
Mee-Kyung Kim ◽  
Jae-Seung Kang
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Orientia Tsutsugamushi ◽  
Murine Macrophages ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Targeted Deletion of Class A Macrophage Scavenger Receptor Increases the Risk of Cardiac Rupture After Experimental Myocardial Infarction

Circulation ◽  
2007 ◽  
Vol 115 (14) ◽  
pp. 1904-1911 ◽  
Author(s):  
Kenichi Tsujita ◽  
Koichi Kaikita ◽  
Takanori Hayasaki ◽  
Tsuyoshi Honda ◽  
Hironori Kobayashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Experimental Myocardial Infarction ◽  
Cardiac Rupture ◽  
Infarcted Myocardium ◽  
Factor Α ◽  
Necrosis Factor

Background— Class A macrophage scavenger receptor (SR-A) is a macrophage-restricted multifunctional molecule that optimizes the inflammatory response by modulation of the activity of inflammatory cytokines. This study was conducted with SR-A–deficient (SR-A −/− ) mice to evaluate the relationship between SR-A and cardiac remodeling after myocardial infarction. Methods and Results— Experimental myocardial infarction (MI) was produced by ligation of the left coronary artery in SR-A −/− and wild-type (WT) male mice. The number of mice that died within 4 weeks after MI was significantly greater in SR-A −/− mice than in WT mice ( P =0.03). Importantly, death caused by cardiac rupture within 1 week after MI was 31% (17 of 54 mice) in SR-A −/− mice and 12% (6 of 51 mice) in WT mice ( P =0.01). In situ zymography demonstrated augmented gelatinolytic activity in the infarcted myocardium in SR-A −/− mice compared with WT mice. Real-time reverse transcription–polymerase chain reaction at day 3 after MI showed that the expression of matrix metalloproteinase-9 mRNA increased significantly in the infarcted myocardium in SR-A −/− mice compared with WT mice. Furthermore, SR-A −/− mice showed augmented expression of tumor necrosis factor-α and reduction of interleukin-10 in the infarcted myocardium at day 3 after MI. In vitro experiments also demonstrated increased tumor necrosis factor-α and decreased interleukin-10 expression in activated SR-A −/− macrophages. Conclusions— The present findings suggest that SR-A deficiency might cause impairment of infarct remodeling that results in cardiac rupture via insufficient production of interleukin-10 and enhanced expression of tumor necrosis factor-α and of matrix metalloproteinase-9. SR-A might contribute to the prevention of cardiac rupture after MI.

Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-α

1995 ◽  
Vol 25 (10) ◽  
pp. 2888-2893 ◽  
Author(s):  
Johannes Barsig ◽  
Sabine Küsters ◽  
Kathrin Vogt ◽  
Hans-Dieter Volk ◽  
Gisa Tiegs ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-α and Interleukin-10 in Viral and Bacterial Gastroenteritis in Children

2005 ◽  
Vol 68 (6) ◽  
pp. 250-253 ◽  
Author(s):  
Ting-Rong Hsu ◽  
Shu-Jen Chen ◽  
Tzee-Chung Wu ◽  
Ruey-Lung Chung ◽  
Ren-Bin Tang
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Bacterial Gastroenteritis ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor–α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis

2011 ◽  
Vol 72 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Yu-Pin Ho ◽  
Cheng-Tang Chiu ◽  
I.-Shyan Sheen ◽  
Shu-Chin Tseng ◽  
Ping Chin Lai ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor
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