Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene

2019 ◽  
Vol 29 (5) ◽  
pp. 520-522 ◽  
Author(s):  
Olga A. Mostovaya ◽  
Yuliya A. Valiullina ◽  
Chang T. Chan ◽  
Olga S. Potrekeeva ◽  
Pavel L. Padnya ◽  
...  
Keyword(s):  
Chymotrypsin Activity

Two-Dimensional Metal–Organic Framework Nanosheets as an Enzyme Inhibitor: Modulation of the α-Chymotrypsin Activity

2017 ◽  
Vol 139 (24) ◽  
pp. 8312-8319 ◽  
Author(s):  
Ming Xu ◽  
Shuai Yuan ◽  
Xin-Yu Chen ◽  
Yu-Jie Chang ◽  
Gregory Day ◽  
...  
Keyword(s):  
Enzyme Inhibitor ◽  
Metal Organic Framework ◽  
Two Dimensional ◽  
Chymotrypsin Activity ◽  
Metal Organic ◽  
Organic Framework

scholarly journals A COLORIMETRIC MICROMETHOD FOR THE ESTIMATION OF CHYMOTRYPSIN ACTIVITY

1954 ◽  
Vol 208 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Herbert A. Ravin ◽  
Philip Bernstein ◽  
Arnold M. Seligman
Keyword(s):  
Chymotrypsin Activity

STUDIES OF FIBROCYSTIC DISEASE OF THE PANCREAS (MUCOVISCIDOSIS): CHYMOTRYPSIN ACTIVITY OF DUODENAL FLUID

PEDIATRICS ◽  
1955 ◽  
Vol 16 (2) ◽  
pp. 207-214
Author(s):  
Reid C. Richmond ◽  
Harry Shwachman
Keyword(s):  
Respiratory Infections ◽  
Pancreatic Insufficiency ◽  
Pancreatic Function ◽  
Control Group ◽  
Fibrocystic Disease ◽  
Complete Evaluation ◽  
Total Enzyme Activity ◽  
Duodenal Fluid ◽  
Chymotrypsin Activity ◽  
Routine Assay

A study of the chymotrypsin activity of duodenal fluid, using the method of Ravin, Bernstein, and Seligman, is presented. The method is applicable to routine assay and is a reliable reflection of pancreatic function. In addition, this assay is specific for chymotrypsin activity in contrast to the customary tests for protease activity, which use casein or gelatin as substrates. In 40 patients with complete pancreatic insufficiency due to fibrocystic disease of the pancreas the chymotrypsin activity of the duodenal fluid was not measurable (i.e., less than 5 µg. of β-naphthol liberated from the substrate). The chymotrypsin activity in 53 patients with normal pancreatic function and without symptoms referable to fibrocystic disease of the pancreas varied from 11 to 65 µg. of βd-naphthol except for the lowest value in this control group of 8 µg. In another group of 62 children with sufficient symptoms to call for duodenal fluid assay (failure to gain, abnormal feces or repeated respiratory infections) the range of chymotrypsin activity was similar to that of the control group. The duodenal fluid assay and clinical course excluded fibrocystic disease of the pancreas in this group. The chymotrypsin assay is useful in the study of patients with partial pancreatic insufficiency from progressive loss of pancreatic function as the disease progresses. In view of occasional diagnostic failures, based on assay of a single enzyme, it is important to determine the total enzyme activity of duodenal fluid for proper complete evaluation of pancreatic function.

scholarly journals The effects of pregnancy and lactation on the activities of trypsin and α-chymotrypsin in the rat pancreas

1979 ◽  
Vol 41 (3) ◽  
pp. 573-578 ◽  
Author(s):  
B. A. Rolls ◽  
M. J. Henschel ◽  
Maureen F. Palmer
Keyword(s):  
Insulin Secretion ◽  
Food Intake ◽  
Nutrient Availability ◽  
Gut Hormones ◽  
Weaning Food ◽  
Rat Pancreas ◽  
Trophic Effects ◽  
Chymotrypsin Activity ◽  
Pregnancy And Lactation ◽  
Pancreas Weight

1. The food intake, pancreas weight and trypsin (EC 3.4.21.4) and α-chymotrypsin (EC 3.4.21.1) activities in the pancreas were measured in rats during pregnancy and lactation and after the young were weaned.2. All the quantities measured increased significantly during lactation and had returned to their original values by 4 weeks after weaning. Food intake and pancreas weight were highest after the second week of lactation. Total trypsin and α-chymotrypsin activity, and the activity per g tissue, fell during pregnancy and rose during lactation, reaching a maximum I week after weaning.3. From these and other results it is suggested that the hypertrophy and hypersecretion of pregnancy and lactation are initiated by changes in insulin secretion and mediated by the trophic effects of gut hormones, and that differences in the nature and timing of the response may be controlled by nutrient availability.

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