Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A)

2018 ◽  
Vol 477 ◽  
pp. 156-162 ◽  
Author(s):  
Magdalena Meyer ◽  
Ilona Berger ◽  
Julia Winter ◽  
Benjamin Jurek
Keyword(s):  
Transcription Factor ◽  
Hypothalamic Neurons ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2

2004 ◽  
Vol 127 (4) ◽  
pp. 1174-1188 ◽  
Author(s):  
Xuemin Wang ◽  
Xiaoli Tang ◽  
Xiaoming Gong ◽  
Efsevia Albanis ◽  
Scott L. Friedman ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Myocyte Enhancer Factor 2 ◽  
Hepatic Stellate Cell Activation ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

scholarly journals Myocyte Enhancer Factor 2C, an Osteoblast Transcription Factor Identified by Dimethyl Sulfoxide (DMSO)-enhanced Mineralization

2011 ◽  
Vol 286 (34) ◽  
pp. 30071-30086 ◽  
Author(s):  
Alexandre S. Stephens ◽  
Sebastien R. Stephens ◽  
Carl Hobbs ◽  
Deitmar W. Hutmacher ◽  
Desa Bacic-Welsh ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dimethyl Sulfoxide ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

scholarly journals A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity

2013 ◽  
Vol 15 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Felix W. Friedrich ◽  
Gilles Dilanian ◽  
Patricia Khattar ◽  
Denise Juhr ◽  
Lucie Gueneau ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Promoter Activity ◽  
Genetic Variant ◽  
Gain Of Function ◽  
Myocyte Enhancer Factor ◽  
Islet 1 ◽  
Enhancer Factor

scholarly journals The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription

2020 ◽  
Vol 295 (25) ◽  
pp. 8613-8627 ◽  
Author(s):  
Liang-Fu Chen ◽  
Michelle R. Lyons ◽  
Fang Liu ◽  
Matthew V. Green ◽  
Nathan G. Hedrick ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Gene Transcription ◽  
Hippocampal Neurons ◽  
Developmental Differences ◽  
Adult Brain ◽  
Synaptic Activity ◽  
Mitogen Activated Protein Kinase ◽  
Subunit Composition ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

N-Methyl-d-aspartate type glutamate receptors (NMDARs) are key mediators of synaptic activity-regulated gene transcription in neurons, both during development and in the adult brain. Developmental differences in the glutamate receptor ionotropic NMDA 2 (GluN2) subunit composition of NMDARs determines whether they activate the transcription factor cAMP-responsive element-binding protein 1 (CREB). However, whether the developmentally regulated GluN3A subunit also modulates NMDAR-induced transcription is unknown. Here, using an array of techniques, including quantitative real-time PCR, immunostaining, reporter gene assays, RNA-Seq, and two-photon glutamate uncaging with calcium imaging, we show that knocking down GluN3A in rat hippocampal neurons promotes the inducible transcription of a subset of NMDAR-sensitive genes. We found that this enhancement is mediated by the accumulation of phosphorylated p38 mitogen-activated protein kinase in the nucleus, which drives the activation of the transcription factor myocyte enhancer factor 2C (MEF2C) and promotes the transcription of a subset of synaptic activity-induced genes, including brain-derived neurotrophic factor (Bdnf) and activity-regulated cytoskeleton-associated protein (Arc). Our evidence that GluN3A regulates MEF2C-dependent transcription reveals a novel mechanism by which NMDAR subunit composition confers specificity to the program of synaptic activity-regulated gene transcription in developing neurons.

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