Protein tyrosine phosphatase SHP-1 modulates osteoblast differentiation through direct association with and dephosphorylation of GSK3β

2017 ◽  
Vol 439 ◽  
pp. 203-212 ◽  
Author(s):  
Xiao-Lu Tang ◽  
Chang-Nan Wang ◽  
Xiao-Yan Zhu ◽  
Xin Ni
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Osteoblast Differentiation ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Direct Association

scholarly journals Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation

2008 ◽  
Vol 22 (5-6) ◽  
pp. 497-506 ◽  
Author(s):  
Willian F. Zambuzzi ◽  
José M. Granjeiro ◽  
Kaushal Parikh ◽  
Saravanan Yuvaraj ◽  
Maikel P. Peppelenbosch ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Osteoblast Differentiation ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

scholarly journals A possible mechanism of low molecular weight protein tyrosine phosphatase (LMW-PTP) activity modulation by glutathione action during human osteoblast differentiation

2009 ◽  
Vol 54 (7) ◽  
pp. 642-650 ◽  
Author(s):  
Tatiana Salles de Souza Malaspina ◽  
Willian Fernando Zambuzzi ◽  
Célio Xavier dos Santos ◽  
Ana Paula Campanelli ◽  
Francisco Rafael Martins Laurindo ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Osteoblast Differentiation ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Human Osteoblast ◽  
Molecular Weight Protein ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

scholarly journals Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin

1998 ◽  
Vol 273 (11) ◽  
pp. 6474-6481 ◽  
Author(s):  
Yu Shen ◽  
Galen Schneider ◽  
Jean-François Cloutier ◽  
André Veillette ◽  
Michael D. Schaller
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Direct Association

1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1742-P
Author(s):  
STEPHANIE M. STANFORD ◽  
MICHAEL A. DIAZ ◽  
JIWEN J. ZOU ◽  
ROBERT J. ARDECKY ◽  
ANTHONY PINKERTON ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
Diabetes Therapy ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

Inhibition of Protein Tyrosine Phosphatase 1B by Lutein Derivatives isolated from Mexican Oregano (Lippia graveolens)

2018 ◽  
Vol 17 (3) ◽  
pp. 134-139
Author(s):  
R.M. Perez-Gutierrez
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Methanol Extract ◽  
Tyrosine Phosphatase ◽  
Positive Control ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Ic50 Value ◽  
Ic50 Values

Methanol extract from Lippia graveolens (Mexican oregano) was studied in order to identify inhibitory bioactives for protein tyrosine phosphatase 1B (PTP1B). Known flavone as lutein (1), and another flavone glycoside such as lutein-7-o-glucoside (2), 6-hydroxy-lutein-7-ohexoside (3) and lutein-7-o-ramnoide (4) were isolated from methanol extract of aerial parts of the Lippia graveolens. All isolates were identified based on extensive spectroscopic data analysis, including UV, IR, NMR, MS and compared with spectroscopic data previously reported. These flavones were evaluated for PTP1B inhibitory activity. Among them, compounds 1 and 3 displayed potential inhibitory activity against PTP1B with IC50 values of 7.01 ± 1.25 μg/ml and 18.4 μg/ml, respectively. In addition, compound 2 and 4 showed moderate inhibitory activity with an IC50 value of 23.8 ± 6.21 and 67.8 ± 5.80 μg/ml respectively. Among the four compounds, luteolin was found to be the most potent PTP1B inhibitor compared to the positive control ursolic acid, with an IC50 value of 8.12 ± 1.06 μg/ml. These results indicate that flavonoids constituents contained in Lippia graveolens can be considered as a natural source for the treatment of type 2 diabetes.

Sign in / Sign up

Export Citation Format

Share Document