The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology

2015 ◽  
Vol 415 ◽  
pp. 133-142 ◽  
Author(s):  
Katarzyna Chojnacka ◽  
Dolores D. Mruk
Keyword(s):  
Tyrosine Kinase ◽  
Sertoli Cell ◽  
Receptor Tyrosine Kinase ◽  
Cell Biology

scholarly journals Survival of the weakest: signaling aided by endosomes

2008 ◽  
Vol 182 (5) ◽  
pp. 823-825 ◽  
Author(s):  
Marisa P. McShane ◽  
Marino Zerial
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Cell Biology ◽  
Tyrosine Kinase Receptor ◽  
Endosomal Trafficking ◽  
Spatiotemporal Regulation ◽  
Molecular Machinery ◽  
Factor C ◽  
Hepatocyte Growth ◽  
Major Target

The tyrosine kinase receptor c-Met plays a key role in cell proliferation, morphogenesis, and motility in response to hepatocyte growth factor. C-Met is often altered in cancer and is a major target for therapeutic intervention. Despite knowing a great deal of the molecular machinery downstream of this receptor tyrosine kinase, the spatiotemporal regulation of c-Met signaling still remains elusive. In this issue of the Journal of Cell Biology, Kermorgant and Parker (Kermorgant, S. and P.J. Parker. 2008. J. Cell Biol. 182:855–863) provide evidence for a model in which the c-Met–activated STAT3 signal is mediated by endosomal trafficking. This study elegantly highlights how weak signals can be effectively transmitted to the nucleus by exploiting endosomal compartments, raising important mechanistic implications for the signaling research community.

scholarly journals ErbB4, a Receptor Tyrosine Kinase, Coordinates Organization of the Seminiferous Tubules in the Developing Testis

2014 ◽  
Vol 28 (9) ◽  
pp. 1534-1546 ◽  
Author(s):  
Florence Naillat ◽  
Ville Veikkolainen ◽  
Ilkka Miinalainen ◽  
Petra Sipilä ◽  
Matti Poutanen ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Sertoli Cell ◽  
Receptor Tyrosine Kinase ◽  
Knockout Mice ◽  
Molecular Mechanisms ◽  
Human Reproduction ◽  
Cell Junction ◽  
Seminiferous Tubules ◽  
Sexually Dimorphic ◽  
3 Dimensional

Although close to every fifth couple nowadays has difficulty conceiving, the molecular mechanisms behind the decline in human reproduction remain poorly understood. We report here that the receptor tyrosine kinase Erbb4 is a candidate causal gene, because it is expressed in a sexually dimorphic manner and is abundant in the developing and adult testes in the mouse. Sertoli cell–specific Erbb4-knockout mice have a compromised 3-dimensional organization of the testicular seminiferous tubules that affects their fertility. More specifically, adhesion defects are observed in the absence of Erbb4, which are characterized by changes in the expression of laminin-1, N-cadherin, claudin-3, and certain cell-cell junction components between the Sertoli and germ cells. Interestingly, Erbb4 knockout also had an effect on the Leydig cells, which suggests a paracrine influence of Sertoli cells expressing ErbB4. Many of the defects observed in Erbb4-knockout mice are rescued in targeted ERBB4 gain-of-function mice, pointing to a coordination role for ErbB4 in the developing testis. Thus, the ErbB4 receptor tyrosine kinase promotes seminiferous tubule development by controlling Sertoli cell and germ cell adhesion.

Emerging Receptor Tyrosine Kinase Drug Targets: Implications for Antibody-Based Therapies for Oncology and Immunologic Disorders

2015 ◽  
Vol 20 (5-6) ◽  
pp. 485-508 ◽  
Author(s):  
Theresa M. LaVallee ◽  
Diego Alvarado ◽  
Andrew J. Garton ◽  
E. Sergio Trombetta ◽  
Richard Gedrich ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Drug Targets
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