Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction

2014 ◽  
Vol 391 (1-2) ◽  
pp. 22-29 ◽  
Author(s):  
Alexandre Luz de Castro ◽  
Angela Vicente Tavares ◽  
Cristina Campos ◽  
Rafael Oliveira Fernandes ◽  
Rafaela Siqueira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Thyroid Hormones ◽  
Stress Reduction ◽  
Rat Model ◽  
Cardioprotective Effects

PPARβ/δ Priming Enhances the Anti-Apoptotic and Therapeutic Properties of Mesenchymal Stromal Cells in Myocardial Ischemia-Reperfusion Injury

2021 ◽  
Author(s):  
Charlotte Sarre ◽  
Rafael Contreras Lopez ◽  
Nitirut Nerpernpisooth ◽  
Christian Barrere ◽  
Sarah Bahraoui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Ex Vivo ◽  
Phase Iii ◽  
Therapeutic Properties ◽  
Cardioprotective Effects

Abstract Background: Mesenchymal Stromal Cells (MSC) have been widely used for their therapeutic properties in many clinical applications including myocardial infarction. Despite promising preclinical results and evidences of safety and efficacy in phases I/ II, inconsistencies in phase III trials have been reported. In a previous study, we have shown using MSC derived from the bone marrow of PPARβ/δ (Peroxisome proliferator-activated receptors β/δ) knockout mice that the acute cardioprotective properties of MSC during the first hour of reperfusion are PPARβ/δ-dependent but not related to the anti-inflammatory effect of MSC. However, the role of the modulation of PPARβ/δ expression on MSC cardioprotective and anti-apoptotic properties has never been investigated. Objectives: The aim of this study was to investigate the role of PPARβ/δ modulation (inhibition or activation) in MSC therapeutic properties in vitro and ex vivo in an experimental model of myocardial infarction.Methods and results: Naïve MSC and MSC pharmacologically activated or inhibited for PPARβ/δ were challenged with H202. Through specific DNA fragmentation quantification and qRT-PCR experiments, we evidenced in vitro an increased resistance to oxidative stress in MSC pre-treated by the PPARβ/δ agonist GW0742 versus naïve MSC. In addition, PPARβ/δ-priming allowed to reveal the anti-apoptotic effect of MSC on co-cultured cardiomyocytes. When injected during reperfusion in an ex vivo heart model of myocardial infarction, PPARβ/δ-primed MSC at a dose of 3.75x105 MSC/heart provided the same cardioprotective efficiency than 7.5x105 naïve MSC, identified as the optimal dose in our model. These enhanced short-term cardioprotective effects were associated with an increase in both anti-apoptotic effects and the number of MSC detected in the left ventricular wall at 1 hour of reperfusion. By contrast, inhibition of PPARβ/δ before their administration in post-ischemic hearts during reperfusion decreased their cardioprotective effects. Conclusion: Altogether these results revealed that PPARβ/δ-primed MSC exhibit an increased resistance to oxidative stress and enhanced anti-apoptotic properties on cardiac cells in vitro. PPARβ/δ-priming appears as an innovative strategy to enhance the cardioprotective effects of MSC and to decrease the injected doses. These results could be of major interest to improve MSC efficacy for the cardioprotection of injured myocardium in AMI patients.

scholarly journals Cardioprotective Effects of Aqueous Extract of Ripped Musa paradisiaca Peel in Isoproterenol Induced Myocardial Infarction Rat Model

2021 ◽  
Vol 8 (10) ◽  
pp. 4634-4648
Author(s):  
Kolawole Yusuf Suleiman ◽  
Emmanuel Oladipo Ajani ◽  
Khalid Talha Biobaku ◽  
Babatunde Sammuel Okediran ◽  
Mistura Oyebisi Azeez ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Aqueous Extract ◽  
Rat Model ◽  
Musa Paradisiaca ◽  
Cardioprotective Effects

Carvedilol and thyroid hormones co-administration mitigates oxidative stress and improves cardiac function after acute myocardial infarction

2019 ◽  
Vol 854 ◽  
pp. 159-166 ◽  
Author(s):  
Vanessa Duarte Ortiz ◽  
Patrick Türck ◽  
Rayane Teixeira ◽  
Bruna Gazzi Lima-Seolin ◽  
Denise Lacerda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thyroid Hormones ◽  
Cardiac Function

scholarly journals Cardioprotective Effects of Gallic Acid on an Isoprenaline-Induced Myocardial Infarction Rat Model

2021 ◽  
Vol 11 (2) ◽  
pp. 174
Author(s):  
AbdelbasetTaher Abdelhalim ◽  
SayedA.M Mahmoud ◽  
NuruddinMohammed Nur ◽  
MossadAbdelhak Shaban ◽  
Sherif Mansour ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Gallic Acid ◽  
Rat Model ◽  
Cardioprotective Effects

scholarly journals Exercise training plays cardioprotection through the oxidative stress reduction in obese rats submitted to myocardial infarction

2012 ◽  
Vol 157 (3) ◽  
pp. 422-424 ◽  
Author(s):  
Viviane A. Barbosa ◽  
Thais F. Luciano ◽  
Marcelo F. Vitto ◽  
Patrícia A. Cesconetto ◽  
Scherolin O. Marques ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Exercise Training ◽  
Stress Reduction ◽  
Obese Rats

scholarly journals Effective Components ofPanax quinquefoliusandCorydalis tuberProtect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mei Xue ◽  
Meilin Liu ◽  
Xinyuan Zhu ◽  
Lin Yang ◽  
Yu Miao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Endoplasmic Reticulum ◽  
Serum Level ◽  
Endoplasmic Reticulum Stress ◽  
Rat Model ◽  
Enzyme Linked Immunosorbent Assay ◽  
High Dose ◽  
Effective Components ◽  
Protein Expressions

Both oxidative stress and endoplasmic reticulum stress (ERS) have been implicated in carcinogenesis and neurological diseases, while there are few reports about the mechanisms of them in the progression of acute myocardial infarction (AMI). This study examined oxidative stress and ERS in a rat model of AMI and evaluated their role in therapy by metoprolol and effective components ofPanax quinquefoliusandCorydalis tuber(EPC). In the present study a rat model of AMI was established by ligation of the left anterior descending coronary artery. After oral administration of metoprolol or low-to-high doses of EPC for 2 weeks, serum malondialdehyde (MDA), superoxide dismutase (SOD), and 8-iso-prostaglandin F2α(8-iso-PGF2α) were detected using enzyme-linked immunosorbent assay (ELISA). Quantitative real-time PCR and Western blotting were used to examine mRNA and protein expressions of the hallmarks of ERS-glucose-regulated protein-78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP). We confirmed that both metoprolol and moderate-to-high dose of EPC decreased 8-iso-PGF2αserum level and downregulated the mRNA and protein expressions of GRP78 and CHOP in myocardium, while EPC also increased SOD serum level. These results indicated that metoprolol and EPC protect the myocardium by attenuating oxidative stress and ERS induced by myocardial infarction, highlighting the ERS pathways as potential therapeutic targets for AMI.

Natural lavender oil (Lavandula angustifolia) exerts cardioprotective effects against myocardial infarction by targeting inflammation and oxidative stress

2018 ◽  
Vol 27 (4) ◽  
pp. 799-807 ◽  
Author(s):  
Faramarz Souri ◽  
Kamran Rakhshan ◽  
Sohaila Erfani ◽  
Yaser Azizi ◽  
Solmaz Nasseri Maleki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Lavandula Angustifolia ◽  
Lavender Oil ◽  
Cardioprotective Effects ◽  
And Oxidative Stress
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