scholarly journals Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors

2013 ◽  
Vol 381 (1-2) ◽  
pp. 160-167 ◽  
Author(s):  
Corina Lesseur ◽  
David A. Armstrong ◽  
Alison G. Paquette ◽  
Devin C. Koestler ◽  
James F. Padbury ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Perinatal Factors ◽  
Tissue Specific ◽  
Promoter Dna Methylation ◽  
Promoter Dna

Role of tissue-specific promoter DNA methylation in regulating the human EKLF gene

2018 ◽  
Vol 71 ◽  
pp. 16-22 ◽  
Author(s):  
Yihong Li ◽  
Dun Liu ◽  
Zhiming Li ◽  
Xinhua Zhang ◽  
Yuhua Ye ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tissue Specific ◽  
Promoter Dna Methylation ◽  
Tissue Specific Promoter ◽  
Promoter Dna

scholarly journals Tissue-specific expression and correlation with promoter DNA methylation of the LBP gene in pigs

2020 ◽  
Vol 19 (4) ◽  
pp. 1055-1064
Author(s):  
Yue CAO ◽  
Zhong-cheng GAO ◽  
Zheng-chang WU ◽  
Hai-fei WANG ◽  
Wen-bin BAO
Keyword(s):  
Dna Methylation ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Promoter Dna Methylation ◽  
Promoter Dna

scholarly journals Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 622
Author(s):  
Omeima Abdullah ◽  
Ziad Omran ◽  
Salman Hosawi ◽  
Ali Hamiche ◽  
Christian Bronner ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dna Methyltransferase ◽  
Ring Finger ◽  
Macromolecular Complex ◽  
Anticancer Activities ◽  
Histone Deacetylase 1 ◽  
Promoter Dna Methylation ◽  
New Gene ◽  
Regulatory Effects ◽  
Promoter Dna

Silencing of tumor suppressor genes (TSGs) through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is considered a main mechanism of tumorigenesis. The abnormal DNA methylation profiles are transmitted from the cancer mother cell to the daughter cells through the involvement of a macromolecular complex in which the ubiquitin-like containing plant homeodomain (PHD), and an interesting new gene (RING) finger domains 1 (UHRF1), play the role of conductor. Indeed, UHRF1 interacts with epigenetic writers, such as DNA methyltransferase 1 (DNMT1), histone methyltransferase G9a, erasers like histone deacetylase 1 (HDAC1), and functions as a hub protein. Thus, targeting UHRF1 and/or its partners is a promising strategy for epigenetic cancer therapy. The natural compound thymoquinone (TQ) exhibits anticancer activities by targeting several cellular signaling pathways, including those involving UHRF1. In this review, we highlight TQ as a potential multitarget single epidrug that functions by targeting the UHRF1/DNMT1/HDAC1/G9a complex. We also speculate on the possibility that TQ might specifically target UHRF1, with subsequent regulatory effects on other partners.

scholarly journals Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianfeng Xu ◽  
Jiejun Shi ◽  
Xiaodong Cui ◽  
Ya Cui ◽  
Jingyi Jessica Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Cellular Heterogeneity ◽  
Biological Functions ◽  
Global Correlation ◽  
Differentially Methylated Genes ◽  
Promoter Dna Methylation ◽  
Functional Consequences ◽  
Promoter Dna ◽  
Underlying Mechanisms

AbstractPromoter DNA methylation is a well-established mechanism of transcription repression, though its global correlation with gene expression is weak. This weak correlation can be attributed to the failure of current methylation quantification methods to consider the heterogeneity among sequenced bulk cells. Here, we introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method. CHALM improves understanding of the functional consequences of DNA methylation, including its correlations with gene expression and H3K4me3. When applied to different methylation datasets, the CHALM method enables detection of differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.

Targets and dynamics of promoter DNA methylation during early mouse development

2010 ◽  
Vol 42 (12) ◽  
pp. 1093-1100 ◽  
Author(s):  
Julie Borgel ◽  
Sylvain Guibert ◽  
Yufeng Li ◽  
Hatsune Chiba ◽  
Dirk Schübeler ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mouse Development ◽  
Promoter Dna Methylation ◽  
Promoter Dna ◽  
Early Mouse
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