scholarly journals Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep

2013 ◽  
Vol 367 (1-2) ◽  
pp. 98-108 ◽  
Author(s):  
Sabine Hombach-Klonisch ◽  
Adrian Danescu ◽  
Farhana Begum ◽  
Maria R. Amezaga ◽  
Stewart M. Rhind ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Sewage Sludge ◽  
Maternal Exposure ◽  
Fetal Thyroid ◽  
Gland Development

scholarly journals Thyroid Hormone Deficiency Before the Onset of Hearing Causes Irreversible Damage to Peripheral and Central Auditory Systems

2000 ◽  
Vol 83 (5) ◽  
pp. 3101-3112 ◽  
Author(s):  
Marlies Knipper ◽  
Christoph Zinn ◽  
Hannes Maier ◽  
Mark Praetorius ◽  
Karin Rohbock ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Auditory System ◽  
Critical Time ◽  
Organ Of Corti ◽  
Thyroid Gland Function ◽  
Distortion Product ◽  
Fetal Thyroid ◽  
Gland Function ◽  
Dependent Processes

Both a genetic or acquired neonatal thyroid hormone (TH) deficiency may result in a profound mental disability that is often accompanied by deafness. The existence of various TH-sensitive periods during inner ear development and general success of delayed, corrective TH treatment was investigated by treating pregnant and lactating rats with the goitrogen methimazole (MMI). We observed that for the establishment of normal hearing ability, maternal TH, before fetal thyroid gland function on estrus days 17–18, is obviously not required. Within a crucial time between the onset of fetal thyroid gland function and the onset of hearing at postnatal day 12 ( P12), any postponement in the rise of TH-plasma levels, as can be brought about by treating lactating mothers with MMI, leads to permanent hearing defects of the adult offspring. The severity of hearing defects that were measured in 3- to 9-mo-old offspring could be increased with each additional day of TH deficiency during this critical period. Unexpectedly, the active cochlear process, assayed by distortion product otoacoustic emissions (DPOAE) measurements, and speed of auditory brain stem responses, which both until now were not thought to be controlled by TH, proved to be TH-dependent processes that were damaged by a delay of TH supply within this critical time. In contrast, no significant differences in the gross morphology and innervation of the organ of Corti or myelin gene expression in the auditory system, detected as myelin basic protein (MBP) and proteolipid protein (PLP) mRNA using Northern blot approach, were observed when TH supply was delayed for few days. These classical TH-dependent processes, however, were damaged when TH supply was delayed for several weeks. These surprising results may suggest the existence of different TH-dependent processes in the auditory system: those that respond to corrective TH supply (e.g., innervation and morphogenesis of the organ of Corti) and those that do not, but require T3 activity during a very tight time window (e.g., active cochlear process, central processes).

scholarly journals Thyroid Gland Development in a Neotenic Goby (Ice Goby, Leucopsarion petersii) and a Common Goby (Ukigori, Gymnogobius urotaenia) during Early Life Stages

2003 ◽  
Vol 20 (7) ◽  
pp. 883-888 ◽  
Author(s):  
Yasuko Harada ◽  
Shigeo Harada ◽  
Izumi Kinoshita ◽  
Masaru Tanaka ◽  
Masatomo Tagawa
Keyword(s):  
Thyroid Gland ◽  
Early Life ◽  
Life Stages ◽  
Early Life Stages ◽  
Gland Development ◽  
Common Goby

Effect of Hypophysectomy of the Pregnant Rat on I131 Metabolism of the Fetal Thyroid Gland

Endocrinology ◽  
1963 ◽  
Vol 73 (4) ◽  
pp. 518-521 ◽  
Author(s):  
B. M. NATAF ◽  
I. L. CHAIKOFF
Keyword(s):  
Thyroid Gland ◽  
Pregnant Rat ◽  
Fetal Thyroid

Thyroid gland development and defects

2008 ◽  
Vol 22 (1) ◽  
pp. 57-75 ◽  
Author(s):  
Juergen Kratzsch ◽  
Ferdinand Pulzer
Keyword(s):  
Thyroid Gland ◽  
Gland Development

scholarly journals Hes1 Is Required for Appropriate Morphogenesis and Differentiation during Mouse Thyroid Gland Development

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e16752 ◽  
Author(s):  
Aurore Carre ◽  
Latif Rachdi ◽  
Elodie Tron ◽  
Bénédicte Richard ◽  
Mireille Castanet ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Gland Development ◽  
Mouse Thyroid

Floating cultures obtained from human fetal thyroid gland

1988 ◽  
Vol 106 (5) ◽  
pp. 1616-1618
Author(s):  
V. N. Blyumkin ◽  
L. A. Kirsanova ◽  
N. N. Skaletskii ◽  
R. P. Babikova ◽  
Yu. V. Kiprenskii
Keyword(s):  
Thyroid Gland ◽  
Fetal Thyroid
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