The role of AMP-activated protein kinase in regulating white adipose tissue metabolism

2013 ◽  
Vol 366 (2) ◽  
pp. 194-203 ◽  
Author(s):  
R.B. Ceddia
Keyword(s):  
Adipose Tissue ◽  
Protein Kinase ◽  
White Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Amp Activated Protein Kinase

Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 34 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Gregory R. Steinberg
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Protein Kinase ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Moderate Intensity ◽  
Amp Activated Protein Kinase

During moderate-intensity exercise, fatty acids are the predominant substrate for working skeletal muscle. The release of fatty acids from adipose tissue stores, combined with the ability of skeletal muscle to actively fine tune the gradient between fatty acid and carbohydrate metabolism, depending on substrate availability and energetic demands, requires a coordinated system of metabolic control. Over the past decade, since the discovery that AMP-activated protein kinase (AMPK) was increased in accordance with exercise intensity, there has been significant interest in the proposed role of this ancient stress-sensing kinase as a critical integrative switch controlling metabolic responses during exercise. In this review, studies examining the role of AMPK as a regulator of fatty acid metabolism in both adipose tissue and skeletal muscle during exercise will be discussed. Exercise induces activation of AMPK in adipocytes and regulates triglyceride hydrolysis and esterfication through phosphorylation of hormone sensitive lipase (HSL) and glycerol-3-phosphate acyl-transferase, respectively. In skeletal muscle, exercise-induced activation of AMPK is associated with increases in fatty acid uptake, phosphorylation of HSL, and increased fatty acid oxidation, which is thought to occur via the acetyl-CoA carboxylase-malony-CoA-CPT-1 signalling axis. Despite the importance of AMPK in regulating fatty acid metabolism under resting conditions, recent evidence from transgenic models of AMPK deficiency suggest that alternative signalling pathways may also be important for the control of fatty acid metabolism during exercise.

scholarly journals Metabolism and secretory function of white adipose tissue: effect of dietary fat

2009 ◽  
Vol 81 (3) ◽  
pp. 453-466 ◽  
Author(s):  
Cláudia M. Oller do Nascimento ◽  
Eliane B. Ribeiro ◽  
Lila M. Oyama
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Dietary Fat ◽  
Dietary Fatty Acids ◽  
Secretory Function ◽  
High Fat ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism

Approximately 40% of the total energy consumed by western populations is represented by lipids, most of them being ingested as triacylglycerols and phospholipids. The focus of this review is to analyze the effect of the type of dietary fat on white adipose tissue metabolism and secretory function, particularly on haptoglobin, TNF-α, plasminogen activator inhibitor-1 and adiponectin secretion. Previous studies have demonstrated that the duration of the exposure to the high-fat feeding, amount of fatty acid present in the diet and the type of fatty acid may or may not have a significant effect on adipose tissue metabolism. However, the long-term or short-term high fat diets, especially rich in saturated fatty acids, probably by activation of toll-like receptors, stimulated the expression of proinflammatory adipokines and inhibited adiponectin expression. Further studies are needed to investigate the cellular mechanisms by which dietary fatty acids affect white adipose tissue metabolism and secretory functions.

Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats

Life Sciences ◽  
2018 ◽  
Vol 199 ◽  
pp. 158-166 ◽  
Author(s):  
Ariclecio Cunha de Oliveira ◽  
Sandra Andreotti ◽  
Rogério António Laurato Sertie ◽  
Amanda Baron Campana ◽  
André Ricardo Gomes de Proença ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glycemic Control ◽  
White Adipose Tissue ◽  
Combined Treatment ◽  
Male Rats ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Reproductive Axis

Endocrine Regulation of Fetal Adipose Tissue Metabolism in the Pig: Role of Thyroxine

Neonatology ◽  
1993 ◽  
Vol 64 (2-3) ◽  
pp. 116-126 ◽  
Author(s):  
D.B. Hausman ◽  
G.J. Hausman ◽  
R.J. Martin
Keyword(s):  
Adipose Tissue ◽  
Endocrine Regulation ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism
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