scholarly journals Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk

2012 ◽  
Vol 354 (1-2) ◽  
pp. 63-73 ◽  
Author(s):  
Wen-Yang Hu ◽  
Guang-Bin Shi ◽  
Dan-Ping Hu ◽  
Jason L. Nelles ◽  
Gail S. Prins
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Progenitor Cells ◽  
Endocrine Disrupting Chemicals ◽  
Prostate Cancer Risk ◽  
Human Prostate ◽  
Endocrine Disrupting

scholarly journals Actions of Estrogenic Endocrine Disrupting Chemicals on Human Prostate Stem/Progenitor Cells and Prostate Carcinogenesis

2016 ◽  
Vol 10 (1) ◽  
pp. 76-97 ◽  
Author(s):  
Dan-Ping Hu ◽  
Wen-Yang Hu ◽  
Lishi Xie ◽  
Ye Li ◽  
Lynn Birch ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Endocrine Disrupting Chemicals ◽  
Human Prostate ◽  
Cancer Management ◽  
Prostate Carcinogenesis ◽  
Endocrine Disrupting ◽  
Cancer Initiation

Substantial evidences from epidemiological and animal-based studies indicate that early exposure to endocrine disrupting chemicals (EDCs) during the developmental stage results in a variety of disorders including cancer. Previous studies have demonstrated that early estrogen exposure results in life-long reprogramming of the prostate gland that leads to an increased incidence of prostatic lesions with aging. We have recently documented that bisphenol A (BPA), one of the most studied EDCs with estrogenic activity has similar effects in increasing prostate carcinogenic potential, supporting the connection between EDCs exposure and prostate cancer risk. It is well accepted that stem cells play a crucial role in development and cancer. Accumulating evidence suggest that stem cells are regulated by extrinsic factors and may be the potential target of hormonal carcinogenesis. Estrogenic EDCs which interfere with normal hormonal signaling may perturb prostate stem cell fate by directly reprogramming stem cells or breaking down the stem cell niche. Transformation of stem cells into cancer stem cells may underlie cancer initiation accounting for cancer recurrence, which becomes a critical therapeutic target of cancer management. We therefore propose that estrogenic EDCs may influence the development and progression of prostate cancer through reprogramming and transforming the prostate stem and early stage progenitor cells. In this review, we summarize our current studies and have updated recent advances highlighting estrogenic EDCs on prostate carcinogenesis by possible targeting prostate stem/progenitor cells. Using novel stem cell assays we have demonstrated that human prostate stem/progenitor cells express estrogen receptors (ER) and are directly modulated by estrogenic EDCs. Moreover, employing anin vivohumanized chimeric prostate model, we further demonstrated that estrogenic EDCs initiate and promote prostatic carcinogenesis in an androgen-supported environment. These findings support our hypothesis that prostate stem/progenitor cells may be the direct targets of estrogenic EDCs as a consequence of developmental exposure which carry permanent reprogrammed epigenetic and oncogenic events and subsequently deposit into cancer initiation and progression in adulthood.

scholarly journals Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk

1998 ◽  
Vol 78 (10) ◽  
pp. 1361-1367 ◽  
Author(s):  
JA Agúndez ◽  
C Martínez ◽  
M Olivera ◽  
L Gallardo ◽  
JM Ladero ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Human Prostate ◽  
Metabolizing Enzymes

scholarly journals Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer

2012 ◽  
Vol 15 (4) ◽  
pp. 339-345 ◽  
Author(s):  
Y Fukuma ◽  
H Matsui ◽  
H Koike ◽  
Y Sekine ◽  
I Shechter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Squalene Synthase ◽  
Human Prostate ◽  
Human Prostate Cancer

Human prostate cancer risk factors

Cancer ◽  
2004 ◽  
Vol 101 (S10) ◽  
pp. 2371-2490 ◽  
Author(s):  
David G. Bostwick ◽  
Harry B. Burke ◽  
Daniel Djakiew ◽  
Susan Euling ◽  
Shuk-mei Ho ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Risk Factors

scholarly journals Deficient Nucleotide Excision Repair Capacity Enhances Human Prostate Cancer Risk

2004 ◽  
Vol 64 (3) ◽  
pp. 1197-1201 ◽  
Author(s):  
Jennifer J. Hu ◽  
M. Craig Hall ◽  
Lawrence Grossman ◽  
Mohammad Hedayati ◽  
David L. McCullough ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Prostate Cancer Risk ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Repair Capacity ◽  
Nucleotide Excision

259: Dna-Repair Genetic Polymorphisms and Prostate Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Prostate Cancer Risk
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