The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes

2011 ◽  
Vol 342 (1-2) ◽  
pp. 41-47 ◽  
Author(s):  
Y. Zhang ◽  
T. Lei ◽  
J.F. Huang ◽  
S.B. Wang ◽  
L.L. Zhou ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Binding Protein ◽  
Regulatory Element ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Evaluation of Total Adiponectin, Adipocyte Fatty Acid Binding Protein and Fibroblast Growth Factor 21 Levels in Individuals With Metabolic Syndrome

2014 ◽  
pp. 219-228 ◽  
Author(s):  
D. NOVOTNY ◽  
H. VAVERKOVA ◽  
D. KARASEK ◽  
J. LUKES ◽  
L. SLAVIK ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Although many studies have investigated the relationships of several adipokines to metabolic syndrome (MetS), the interrelationships of adiponectin (ADP), adipocyte fatty acid binding protein (A-FABP) and fibroblast growth factor 21 (FGF 21) have not been described in detail. We examined 209 asymptomatic dyslipidemic patients divided into MetS+ (n=73) and MetS- (n=136) groups. The aim of study was to evaluate the relationships between observed adipokines, to compare the levels of total ADP, A-FABP and FGF 21 in individuals with and without MetS, and to elucidate the relationships of individual adipokines to lipid parameters, markers of insulin resistance and endothelial hemostatic markers in these groups. In MetS+ group, we found the independent positive association ADP with A-FABP (beta=0.4888, p=0.0382), A-FABP with FGF 21 (beta=0.3811, p=0.0002) and von Willebrand factor (beta=0.4502, p=0.0013), and FGF 21 with A-FABP (beta=0.4422, p=0.0002). Our study has confirmed the well-established risk profile of subjects with MetS, although clinically asymptomatic. MetS+ patients had also lower levels of ADP and higher levels of A-FABP and FGF 21. Our study evaluated the interrelationships of ADP, A-FABP and FGF 21 in asymptomatic dyslipidemic subjects with diagnosis of MetS. Especially strong association between A-FABP and FGF 21 needs to be clarified in further studies.

scholarly journals Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

Oncogene ◽  
2000 ◽  
Vol 19 (45) ◽  
pp. 5173-5181 ◽  
Author(s):  
Johannes V Swinnen ◽  
Hannelore Heemers ◽  
Ludo Deboel ◽  
Fabienne Foufelle ◽  
Walter Heyns ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Growth Factor ◽  
Fatty Acid Synthase ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Stimulation Of
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