scholarly journals Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia

2009 ◽  
Vol 311 (1-2) ◽  
pp. 69-76 ◽  
Author(s):  
Mamdouh H. Kedees ◽  
Marine Grigoryan ◽  
Yelena Guz ◽  
Gladys Teitelman
Keyword(s):  
Differential Expression ◽  
Beta Cells ◽  
Alpha Cell ◽  
Cell Hyperplasia ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

Diabetologia ◽  
2011 ◽  
Vol 54 (6) ◽  
pp. 1379-1387 ◽  
Author(s):  
A. M. K. Hansen ◽  
T. B. Bödvarsdottir ◽  
D. N. E. Nordestgaard ◽  
R. S. Heller ◽  
C. F. Gotfredsen ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Alpha Cell ◽  
Psammomys Obesus ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

Nature ◽  
1993 ◽  
Vol 361 (6410) ◽  
pp. 362-365 ◽  
Author(s):  
George G. Holz IV ◽  
Willem M. Kiihtreiber ◽  
Joel F. Habener
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Alessandra Puddu ◽  
Roberta Sanguineti ◽  
Arianna Durante ◽  
Alessio Nencioni ◽  
François Mach ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Redox Balance ◽  
Insulin Gene ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Pancreatic Beta Cell Function

Advanced glycation end products (AGEs) might play a pathophysiological role in the development of diabetes and its complications. AGEs negatively affect pancreatic beta-cell function and the expression of transcriptional factors regulating insulin gene. Glucagon-like peptide-1 (GLP-1), an incretin hormone that regulates glucose homeostasis, might counteract the harmful effects of AGEs on the beta cells in culture. The aim of this study was to identify the intracellular mechanisms underlying GLP-1-mediated protection from AGE-induced detrimental activities in pancreatic beta cells. HIT-T15 cells were cultured for 5 days with glycated serum (GS, consisting in a pool of AGEs), in the presence or absence of 10 nmol/L GLP-1. After evaluation of oxidative stress, we determined the expression and subcellular localization of proteins involved in maintaining redox balance and insulin gene expression, such as nuclear factor erythroid-derived 2 (Nrf2), glutathione reductase, PDX-1, and MafA. Then, we investigated proinsulin production. The results showed that GS increased oxidative stress, reduced protein expression of all investigated factors through proteasome activation, and decreased proinsulin content. Furthermore, GS reduced ability of PDX-1 and MafA to bind DNA. Coincubation with GLP-1 reversed these GS-mediated detrimental effects. In conclusion, GLP-1, protecting cells against oxidants, triggers protective intercellular pathways in HIT-T15 cells exposed to GS.

Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors

Diabetes ◽  
1998 ◽  
Vol 47 (1) ◽  
pp. 66-72 ◽  
Author(s):  
K. Moens ◽  
D. Flamez ◽  
C. Van Schravendijk ◽  
Z. Ling ◽  
D. Pipeleers ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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