Estrogen receptor beta (ERbeta) and inhibition of prostate cancer cell proliferation: Studies on the possible mechanism of action in DU145 cells

2007 ◽  
Vol 263 (1-2) ◽  
pp. 46-54 ◽  
Author(s):  
A. Pravettoni ◽  
O. Mornati ◽  
P.G.V. Martini ◽  
M. Marino ◽  
A. Colciago ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Mechanism Of Action ◽  
Prostate Cancer Cell ◽  
Estrogen Receptor Beta ◽  
Cancer Cell Proliferation ◽  
Du145 Cells ◽  
Receptor Beta

Estrogen receptor beta (ERβ) mediates expression of β-catenin and proliferation in prostate cancer cell line PC-3

2016 ◽  
Vol 430 ◽  
pp. 12-24 ◽  
Author(s):  
Ana Paola G. Lombardi ◽  
Raisa Pisolato ◽  
Carolina M. Vicente ◽  
Maria Fatima M. Lazari ◽  
Thaís F.G. Lucas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Estrogen Receptor Beta ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Receptor Beta

scholarly journals Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yun Luo ◽  
Jie-Ying Wu ◽  
Min-Hua Lu ◽  
Zhi Shi ◽  
Ning Na ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Mapk Signaling ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Du145 Cells ◽  
Mapk Signaling Pathways

TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization. Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well. Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways.

scholarly journals Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol

2018 ◽  
Vol 9 ◽  
Author(s):  
Shiro Hiramitsu ◽  
Tomonori Ishikawa ◽  
Wan-Ru Lee ◽  
Tamor Khan ◽  
Christine Crumbley ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Estrogen Receptor Beta ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Receptor Beta

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Attenuates Prostate Cancer Cell Proliferation via Phosphorylation of MKP-1

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1957-P
Author(s):  
TAKAKO KAWANAMI ◽  
TAKASHI NOMIYAMA ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
TOSHIHIKO YANASE
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Receptor Agonist ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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