The p38 MAPK signaling pathway: A major regulator of skeletal muscle development

2006 ◽  
Vol 252 (1-2) ◽  
pp. 224-230 ◽  
Author(s):  
Aviad Keren ◽  
Yael Tamir ◽  
Eyal Bengal
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Muscle Development ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Skeletal Muscle Development

scholarly journals Inhibition of the JNK/MAPK signaling pathway by myogenesis-associated miRNAs is required for skeletal muscle development

2018 ◽  
Vol 25 (9) ◽  
pp. 1581-1597 ◽  
Author(s):  
Shu-Juan Xie ◽  
Jun-Hao Li ◽  
Hua-Feng Chen ◽  
Ye-Ya Tan ◽  
Shu-Rong Liu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathway ◽  
Muscle Development ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Skeletal Muscle Development

scholarly journals Gga-miR-3525 Targets PDLIM3 through the MAPK Signaling Pathway to Regulate the Proliferation and Differentiation of Skeletal Muscle Satellite Cells

2020 ◽  
Vol 21 (15) ◽  
pp. 5573
Author(s):  
Huadong Yin ◽  
Jing Zhao ◽  
Haorong He ◽  
Yuqi Chen ◽  
Yan Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Rate ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Satellite Cells ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Muscle Satellite Cells ◽  
Skeletal Muscle Satellite Cells ◽  
Proliferation And Differentiation

MicroRNAs (miRNAs) are evolutionarily conserved, small noncoding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence demonstrates that miRNAs are important regulators in the development of skeletal muscle satellite cells (SMSCs). Our previous research showed that gga-miR-3525 is differentially expressed in breast muscle of broilers (high growth rate) and layers (low growth rate). In this study, we report a new role for gga-miR-3525 as a myogenic miRNA that regulates skeletal muscle development in chickens. Exogenous increases in the expression of gga-miR-3525 significantly inhibited proliferation and differentiation of SMSCs, whereas the opposite effects were observed in gga-miR-3525 knockdown SMSCs. We confirmed that PDLIM3 (PDZ and LIM domain 3) is a target gene of gga-miR-3525 that can promote proliferation and differentiation of SMSCs. We found that PDLIM3 overexpression elevated the abundance of phosphorylated (p-)p38 protein but that the gga-miR-3525 mimic and p38-MAPK inhibitor (SB203580) weakened the activation of p-p38. Furthermore, treatment with SB203580 reduced the promoting effect of PDLIM3 on SMSC proliferation and differentiation. Overall, our results indicate that gga-miR-3525 regulates the proliferation and differentiation of SMSCs by targeting PDLIM3 via the p38/MAPK signaling pathway in chickens.

scholarly journals Comprehensive Analysis of LncRNA Reveals the Temporal-Specific Module of Goat Skeletal Muscle Development

2019 ◽  
Vol 20 (16) ◽  
pp. 3950 ◽  
Author(s):  
Yinghui Ling ◽  
Qi Zheng ◽  
Menghua Sui ◽  
Lu Zhu ◽  
Lina Xu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathway ◽  
Muscle Development ◽  
Developmental Stages ◽  
Mapk Signaling ◽  
Capra Hircus ◽  
Skeletal Muscle Development ◽  
Complex Processes ◽  
P53 Signaling ◽  
Functional Transition

A series of complex processes regulate muscle development, and lncRNAs play essential roles in the regulation of skeletal myogenesis. Using RNA sequencing, we profiled the lncRNA expression during goat (Capra hircus) skeletal muscle development, which included seven stages across fetal 45 (F45), 65 (F65), 90 (F90), 120 (F120), 135 (F135) days, born for 24 h (B1) and 90 (B90) days. A total of 15,079 lncRNAs were identified in the seven stages, and they were less conservative with other species (human, cow, and mouse). Among them, 547 were differentially expressed, and they divided the seven stages into three functional transition periods. Following weighted gene co-expression network analysis (WGCNA), five lncRNA modules specific for developmental stages were defined as three types: ‘Early modules’, ‘late modules’, and ‘individual-stage-specific modules’. The enrichment content showed that ‘early modules’ were related to muscle structure formation, ‘late modules’ participated in the ‘p53 signaling pathway’ and other pathways, the F90-highly related module was involved in the ‘MAPK signaling pathway’, and other pathways. Furthermore, we identified hub-lncRNA in three types of modules, and LNC_011371, LNC_ 007561, and LNC_001728 may play important roles in goat skeletal muscle. These data will facilitate further exploration of skeletal muscle lncRNA functions at different developmental stages in goats.

Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells

2012 ◽  
Vol 33 (12) ◽  
pp. 1500-1505 ◽  
Author(s):  
Yu Sun ◽  
Shusheng Tang ◽  
Xi Jin ◽  
Chaoming Zhang ◽  
Wenxia Zhao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
S Phase ◽  
Mapk Signaling Pathway ◽  
Phase Cell ◽  
Human Hepatoma ◽  
Cycle Arrest
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