scholarly journals Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha

2005 ◽  
Vol 232 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
Shih-Yi Lin ◽  
Wayne Huey-Herng Sheu ◽  
Wen-Yin Chen ◽  
Fa-Yauh Lee ◽  
Ching-Jang Huang
Keyword(s):  
Liver Cirrhosis ◽  
Bile Duct ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Bile Duct Ligation ◽  
Necrosis Factor Alpha ◽  
Duct Ligation ◽  
Factor Alpha ◽  
Necrosis Factor

Tumor necrosis factor-alpha stimulates adrenal glucocorticoid secretion in cholestatic rats

1996 ◽  
Vol 270 (6) ◽  
pp. G987-G991 ◽  
Author(s):  
M. G. Swain ◽  
M. Maric
Keyword(s):  
Bile Duct ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Corticosterone Secretion ◽  
Factor Alpha ◽  
Adrenal Corticosterone ◽  
Necrosis Factor

Tumor necrosis factor-alpha (TNF-alpha ) is capable of activating the hypothalamic-pituitary-adrenal (HPA) axis. We have recently documented altered activation of this axis by endotoxin and interleukin-1 in cholestatic rats. Therefore, in this study, we examined TNF-alpha-induced activation of the HPA axis, in rats with cholestasis due to bile duct resection, with the use of sham-resected rats as controls. Administration of TNF-alpha to bile duct- and sham-resected rats in vivo resulted in a similar increase in plasma adrenocorticotropic hormone levels in both groups of animals but significantly higher corticosterone levels in cholestatic rats, suggesting a direct steroidogenic effect of TNF-alpha in cholestatic rats. This suggestion was confirmed in further experiments by the demonstration of TNF-alpha-induced corticosterone secretion in hypophysectomized cholestatic but not control rats. Furthermore, a direct stimulatory effect of TNF-alpha on adrenal corticosterone secretion in vitro was noted only for cholestatic rats, possibly via augmented adrenal prostaglandin E2 (PGE2) production. These results indicate that TNF-alpha has a direct stimulatory effect on adrenal corticosterone secretion in cholestatic rats, possibly due to augmented adrenal PGE2 release.

scholarly journals Influence of Genetic Polymorphisms of Tumor Necrosis Factor Alpha and Interleukin 10 Genes on the Risk of Liver Cirrhosis in HIV-HCV Coinfected Patients

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66619 ◽  
Author(s):  
Sara Corchado ◽  
Mercedes Márquez ◽  
Montserrat Montes de Oca ◽  
Paula Romero-Cores ◽  
Clotilde Fernández-Gutiérrez ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Tumor Necrosis Factor ◽  
Genetic Polymorphisms ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 10 ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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