Expression and function of the human mineralocorticoid receptor: lessons from transgenic mouse models

2004 ◽  
Vol 217 (1-2) ◽  
pp. 127-136 ◽  
Author(s):  
Damien Le Menuet ◽  
Say Viengchareun ◽  
Martine Muffat-Joly ◽  
Maria-Christina Zennaro ◽  
Marc Lombès
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Mineralocorticoid Receptor ◽  
Transgenic Mouse Models ◽  
And Function

scholarly journals Transgenic mouse models to study human mineralocorticoid receptor function in vivo

2000 ◽  
Vol 57 (4) ◽  
pp. 1299-1306 ◽  
Author(s):  
Damien Le Menuet ◽  
Maria-Christina Zennaro ◽  
Say Viengchareun ◽  
Marc Lombès
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Mineralocorticoid Receptor ◽  
Transgenic Mouse Models ◽  
Receptor Function

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

Science ◽  
2021 ◽  
Vol 372 (6540) ◽  
pp. eaba2374 ◽  
Author(s):  
Shamik Mascharak ◽  
Heather E. desJardins-Park ◽  
Michael F. Davitt ◽  
Michelle Griffin ◽  
Mimi R. Borrelli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mechanical Strength ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Transgenic Mouse Models ◽  
Fibrotic Response ◽  
Mechanical Tension ◽  
Form And Function ◽  
And Function ◽  
Tissue Form

Skin scarring, the end result of adult wound healing, is detrimental to tissue form and function. Engrailed-1 lineage–positive fibroblasts (EPFs) are known to function in scarring, but Engrailed-1 lineage–negative fibroblasts (ENFs) remain poorly characterized. Using cell transplantation and transgenic mouse models, we identified a dermal ENF subpopulation that gives rise to postnatally derived EPFs by activating Engrailed-1 expression during adult wound healing. By studying ENF responses to substrate mechanics, we found that mechanical tension drives Engrailed-1 activation via canonical mechanotransduction signaling. Finally, we showed that blocking mechanotransduction signaling with either verteporfin, an inhibitor of Yes-associated protein (YAP), or fibroblast-specific transgenic YAP knockout prevents Engrailed-1 activation and promotes wound regeneration by ENFs, with recovery of skin appendages, ultrastructure, and mechanical strength. This finding suggests that there are two possible outcomes to postnatal wound healing: a fibrotic response (EPF-mediated) and a regenerative response (ENF-mediated).

Transgenic mouse models of type I diabetes

Diabetes ◽  
1990 ◽  
Vol 39 (8) ◽  
pp. 879-884 ◽  
Author(s):  
M. A. Lipes ◽  
G. S. Eisenbarth
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Type I Diabetes ◽  
Type I ◽  
Transgenic Mouse Models

scholarly journals Characterization of tumor‐associated macrophages in prostate cancer transgenic mouse models

The Prostate ◽  
2021 ◽  
Author(s):  
Amber E. Groot ◽  
Kayla V. Myers ◽  
Timothy E. G. Krueger ◽  
Ashley L. Kiemen ◽  
Natalia H. Nagy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Transgenic Mouse Models ◽  
Tumor Associated Macrophages

2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer

2012 ◽  
Vol 77 ◽  
pp. 40-58 ◽  
Author(s):  
Megan A.S. Penno ◽  
Manuela Klingler-Hoffmann ◽  
Julie A. Brazzatti ◽  
Alex Boussioutas ◽  
Tracy Putoczki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Human Gastric Cancer ◽  
Transgenic Mouse Models ◽  
Protein Biomarkers ◽  
2D Dige ◽  
Candidate Protein ◽  
Dige Analysis
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