scholarly journals Collagen XV, a multifaceted multiplexin present across tissues and species

2020 ◽  
Vol 6-7 ◽  
pp. 100023 ◽  
Author(s):  
Sandrine Bretaud ◽  
Emilie Guillon ◽  
Sanna-Maria Karppinen ◽  
Taina Pihlajaniemi ◽  
Florence Ruggiero
Keyword(s):  
Collagen Xv

Collagen XV as a bone matrix organizer

2013 ◽  
Author(s):  
David Vicente ◽  
Mikko Finnila ◽  
Valerio Izzi ◽  
Jarkko Koivunen ◽  
Taina Pihlajaniemi
Keyword(s):  
Bone Matrix ◽  
Collagen Xv

scholarly journals Slow Muscle Precursors Lay Down a Collagen XV Matrix Fingerprint to Guide Motor Axon Navigation

2016 ◽  
Vol 36 (9) ◽  
pp. 2663-2676 ◽  
Author(s):  
Emilie Guillon ◽  
Sandrine Bretaud ◽  
Florence Ruggiero
Keyword(s):  
Slow Muscle ◽  
Motor Axon ◽  
Collagen Xv

scholarly journals Collagen XV Is Necessary for Modeling of the Extracellular Matrix and Its Deficiency Predisposes to Cardiomyopathy

2010 ◽  
Vol 107 (10) ◽  
pp. 1241-1252 ◽  
Author(s):  
Karolina Rasi ◽  
Jarkko Piuhola ◽  
Marcus Czabanka ◽  
Raija Sormunen ◽  
Mika Ilves ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Collagen Xv

scholarly journals Collagen XV Inhibits Epithelial to Mesenchymal Transition in Pancreatic Adenocarcinoma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72250 ◽  
Author(s):  
Anthony G. Clementz ◽  
Michael J. Mutolo ◽  
Shih-Hsing Leir ◽  
Kirsten J. Morris ◽  
Karolina Kucybala ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Adenocarcinoma Cells ◽  
Collagen Xv

Antiangiogenic Activity of Restin, NC10 Domain of Human Collagen XV: Comparison to Endostatin

1999 ◽  
Vol 255 (3) ◽  
pp. 735-739 ◽  
Author(s):  
Ramani Ramchandran ◽  
Mohanraj Dhanabal ◽  
Ruediger Volk ◽  
Matthew J.F. Waterman ◽  
Mark Segal ◽  
...  
Keyword(s):  
Antiangiogenic Activity ◽  
Human Collagen ◽  
Collagen Xv

scholarly journals Crystal structure of the human collagen XV trimerization domain: A potent trimerizing unit common to multiplexin collagens

2011 ◽  
Vol 30 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Jacqueline A. Wirz ◽  
Sergei P. Boudko ◽  
Thomas F. Lerch ◽  
Michael S. Chapman ◽  
Hans Peter Bächinger
Keyword(s):  
Crystal Structure ◽  
Human Collagen ◽  
Collagen Xv

scholarly journals Tumor suppression by collagen XV is independent of the restin domain

2012 ◽  
Vol 31 (5) ◽  
pp. 285-289 ◽  
Author(s):  
Michael J. Mutolo ◽  
Kirsten J. Morris ◽  
Shih-Hsing Leir ◽  
Thomas C. Caffrey ◽  
Marzena A. Lewandowska ◽  
...  
Keyword(s):  
Tumor Suppression ◽  
Collagen Xv

scholarly journals Collagen XV Promotes ER Stress-Induced Inflammation through Activating Integrin β1/FAK Signaling Pathway and M1 Macrophage Polarization in Adipose Tissue

2021 ◽  
Vol 22 (18) ◽  
pp. 9997
Author(s):  
Changxing Li ◽  
Yuexia Liu ◽  
Yizhou Li ◽  
Ruiqing Tai ◽  
Zhuwen Sun ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Er Stress ◽  
Macrophage Polarization ◽  
Ecm Remodeling ◽  
Homologous Protein ◽  
M1 Macrophage ◽  
Abnormal Accumulation ◽  
New Ideas ◽  
Factor Α ◽  
Collagen Xv

Collagen XV (Col XV), a basement membrane (BM) component, is highly expressed in adipose tissue, and studies have found that Col XV is related to extracellular matrix (ECM) remodeling involving in adipose tissue fibrosis and inflammation. Furthermore, the ECM is essential for maintaining normal development and tissue function. In this study, we found that Col XV is related to the endoplasmic reticulum stress (ERS) and inflammation of adipose tissue. Moreover, we found that overexpression of Col XV in mice could cause macrophages to infiltrate white adipose tissue (iWAT). At the same time, the expression of the ERS sensor IRE1α (Inositol-Requiring Enzyme-1α) was significantly up-regulated, which intensified the inflammation of adipose tissue and the polarization of M1 macrophages after the overexpression of Col XV in mice. In addition, after overexpression of Col XV, the intracellular Ca2+ concentration was significantly increased. Using focal adhesion kinase (FAK) inhibitor PF573228, we found that PF-573228 inhibited the phosphorylation of FAK and reversed the upward trend of Col XV-induced protein expression levels of IRE1α, C/EBP-homologous protein (CHOP), and 78 kDa glucose-regulated protein (GRP78). After treatment with IRE1α inhibitor STF-083010, the results showed that the expression of adipocyte inflammation-related genes interleukin 6 (IL-6) and tumor necrosis factor α (TNFα) significantly were decreased. Our results demonstrate that Col XV induces ER-stress in adipocytes by activating the Integrinβ1/FAK pathway and disrupting the intracellular Ca2+ balance. At the same time, Col XV regulates the inflammation induced by ER stress in adipocytes by promoting IRE1α/XBP1 (X-Box binding protein 1) signaling. Our study provides new ideas for solving the problems of adipose tissue metabolism disorders caused by abnormal accumulation of ECM.

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