scholarly journals Childhood experiences of parenting and age at menarche, age at menopause and duration of reproductive lifespan: Evidence from the English Longitudinal Study of Ageing

Maturitas ◽  
2019 ◽  
Vol 122 ◽  
pp. 66-72 ◽  
Author(s):  
Panayotes Demakakos ◽  
Nora Pashayan ◽  
Georgios Chrousos ◽  
Eleni Linara-Demakakou ◽  
Gita D. Mishra
Keyword(s):  
Longitudinal Study ◽  
Age At Menarche ◽  
Childhood Experiences ◽  
Age At Menopause ◽  
English Longitudinal Study ◽  
Menarche Age

Age at menarche, age at menopause and duration of fertility as risk factors for osteoporosis

Climacteric ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 63-71 ◽  
Author(s):  
C. Sioka ◽  
A. Fotopoulos ◽  
A. Georgiou ◽  
X. Xourgia ◽  
A. Papadopoulos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Menarche Age

scholarly journals Age at menarche, age at menopause, reproductive years and risk of fatal stroke occurrence among Chinese women: the Guangzhou Biobank Cohort Study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhi-bing Hu ◽  
Ze-xiong Lu ◽  
Feng Zhu
Keyword(s):  
Cohort Study ◽  
Postmenopausal Women ◽  
Proportional Hazards ◽  
Chinese Women ◽  
Cox Proportional Hazards ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Fatal Stroke ◽  
Increased Risk ◽  
Menarche Age

Abstract Background The relationship between women’s reproductive characteristics and stroke events is unclear. We aimed to investigate age at menarche, age at menopause and number of reproductive years in relation to fatal stroke occurrence in the Guangzhou Biobank Cohort Study. Methods In total, 16,504 postmenopausal women without stroke, heart disease or a cancer history at baseline were included and followed up for a median of 12.0 years. After review of available records, 222 stroke deaths were recorded. Cox proportional hazards regression was used to assess the associations between the risk of fatal stroke occurrence and age at menarche, age at menopause and number of reproductive years. Results In the whole cohort, compared with those aged 15 years at menarche, an increased risk of fatal stroke among women at menarche showed respectively in those aged 12 years (aHR (adjusted hazard ratio) = 1.86, 95% confidence interval (CI) 0.96–3.60), aged 13 years (aHR = 1.69, 95% CI 0.98–2.92), aged 17 years (aHR = 1.83, 95% CI 1.10–3.05) and aged ≥ 18 years (aHR = 1.66, 95% CI 1.03–2.70), wherein the associations revealed an atypically U-shaped; similar U-shaped association to the cohort of postmenopausal women born before 1940 released a range of incremental risks of fatal stroke in women at menarche aged ≤ 12 years (aHR = 3.68, 95% CI 1.68–8.05), aged 13 years (aHR = 2.11, 95% CI 1.02–4.34), aged 14 years (aHR = 2.07, 95% CI 1.04), aged 17 years (aHR = 2.30, 95% CI 1.20–4.39) and aged 18 years (aHR = 2.50, 95% CI 1.37–4.57), respectively. Compared with menopausal women aged 51–52 years, those aged < 43 years at menopause had an increased risk for fatal stroke among postmenopausal women born in and after 1940 (aHR = 1.64, 95% CI 0.97–2.78) and postmenopausal women born before 1940 (aHR = 1.97, 95% CI 1.05–3.69). Additionally, compared with those with 32–34 reproductive years, women with ≤ 28 reproductive years had an increased risk for fatal stroke in the whole cohort (aHR = 1.91, 95% CI 1.28–2.86) and the cohort of postmenopausal women born before 1940 (aHR = 1.79, 95% CI 1.15–2.80). Conclusions Younger and older age at menarche, younger age at menopause and fewer reproductive ages were related to an increased risk of fatal stroke in postmenopausal women.

Age at menarche, age at menopause and duration of fertility as risk factors for osteoporosis

Climacteric ◽  
2009 ◽  
pp. 1-9 ◽  
Author(s):  
C. Sioka ◽  
A. Fotopoulos ◽  
A. Georgiou ◽  
X. Xourgia ◽  
A. Papadopoulos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Menarche Age

scholarly journals Age At Menarche, Age At Menopause, Reproductive Years and Risk of Fatal Stroke Occurrence Among Chinese Women: The Guangzhou Biobank Cohort Study

2021 ◽  
Author(s):  
Zhi-bing Hu ◽  
Ze-xiong Lu ◽  
Feng Zhu
Keyword(s):  
Cohort Study ◽  
Ischaemic Stroke ◽  
Postmenopausal Women ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Fatal Stroke ◽  
Increased Risk ◽  
Menarche Age

Abstract Background The relationship between women’s reproductive characteristics and stroke events is unclear. We aimed to investigate age at menarche, age at menopause and number of reproductive years in relation to fatal stroke occurrence in the Guangzhou Biobank Cohort Study. Methods In total, 16504 postmenopausal women without stroke, heart disease or a cancer history at baseline were included and followed up for a median of 12.0 years. After review of available records, 222 stroke deaths were recorded. Cox proportional hazards regression was used to assess the associations between the risk of fatal stroke occurrence and age at menarche, age at menopause and number of reproductive years. Results In the whole cohort, compared with those aged 15 years at menarche, women aged 17 years at menarche had an increased risk for fatal stroke (adjusted hazard ratio [aHR] = 1.83, 95% confidence interval (CI) 1.10–3.05) and fatal haemorrhagic stroke (HR = 2.65, 95% CI 1.14–6.18), and women aged ≥ 18 years at menarche had an increased risk for fatal stroke (HR = 1.66, 95% CI 1.03–2.70) and fatal ischaemic stroke (HR = 2.01, 95% CI 1.01–3.99). Among postmenopausal women born before 1940, women aged < 43 years at menopause had an increased risk for fatal stroke (HR = 1.97, 95% CI 1.05–3.69) compared with those aged 51–52 years at menopause. Additionally, in the whole cohort, women with ≤ 28 reproductive years had an increased risk for fatal stroke (HR = 1.91, 95% CI 1.28–2.86) and fatal ischaemic stroke (HR = 2.26, 95% CI 1.26–4.05) compared with those with 32–34 reproductive years; postmenopausal women born before 1940 had a similar risk for fatal stroke and fatal ischaemic stroke. Conclusions Older age at menarche, younger age at menopause and fewer reproductive ages were related to an increased risk of fatal stroke in postmenopausal women.

scholarly journals Adverse Childhood Experiences and Rate of Memory Decline From Mid to Later-Life: Evidence From the English Longitudinal Study of Ageing

2021 ◽  
Author(s):  
Brendan Q O’Shea ◽  
Panayotes Demakakos ◽  
Dorina Cadar ◽  
Lindsay C Kobayashi
Keyword(s):  
Longitudinal Study ◽  
Foster Care ◽  
Adverse Childhood Experiences ◽  
Later Life ◽  
Childhood Experiences ◽  
Memory Decline ◽  
Adverse Childhood ◽  
Rate Of Decline ◽  
English Longitudinal Study

Abstract Evidence on the role of early-life adversity in later-life memory decline is conflicting. We investigated the relationships between adverse childhood experiences (ACEs) and memory performance and rate of decline over a ten-year follow-up among mid-to-older adults in England. Data were from biennial interviews with 5,223 participants aged 54+ in the population-representative English Longitudinal Study of Ageing from 2006/07-2016/17. We examined self-reports of nine ACEs prior to age 16, which related to abuse, household dysfunction, and separation from family. Memory was assessed at each time point as immediate and delayed recall of 10 words. Using linear mixed-effects models with person-specific random intercepts and slopes and adjusted for baseline age, age2, sex, ethnicity, and childhood socioeconomic factors, we observed that most individual and cumulative ACE exposures had null-to-weakly negative associations with memory function and rate of decline over the 10-year follow-up. Having lived in residential or foster care was associated with lower baseline memory (adjusted β = -0.124 standard deviation units, 95% confidence interval: -0.273, -0.025), but not memory decline. Our findings suggest potential long-run impacts of residential or foster care on memory, and highlight the need for accurate and detailed exposure measures when studying ACEs in relation to later-life cognitive outcomes.

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