scholarly journals Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

Maturitas ◽  
2018 ◽  
Vol 116 ◽  
pp. 83-88 ◽  
Author(s):  
Marta Pineda-Moncusí ◽  
Miguel Angel Garcia-Perez ◽  
Abora Rial ◽  
Guillem Casamayor ◽  
Maria Lourdes Cos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Healthy Women ◽  
Vitamin D Levels

scholarly journals Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies

2017 ◽  
Vol 17 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Kejia Hu ◽  
David Frederick Callen ◽  
Jiayuan Li ◽  
Hong Zheng
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Overall Survival ◽  
Cancer Patients ◽  
Dose Response ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Breast Cancer Patients ◽  
Fixed Effects Model ◽  
Vitamin D Levels

Studies have shown that vitamin D could have a role in breast cancer survival; however, the evidence of the relationship between patients’ vitamin D levels and their survival has been inconsistent. This meta-analysis explores possible dose-response relationships between vitamin D levels and overall survival by allowing for differences in vitamin D levels among populations of the various studies. Studies relating vitamin D (25-OH-D [25-hydroxyvitamin D]) levels in breast cancer patients with their survival were identified by searching PubMed and Embase. A pooled HR (hazard ratio) comparing the highest with the lowest category of circulating 25-OH-D levels were synthesized using the Mantel-Haenszel method under a fixed-effects model. A two-stage fixed-effects dose-response model including both linear (a log-linear dose-response regression) and nonlinear (a restricted cubic spline regression) models were used to further explore possible dose-response relationships. Six studies with a total number of 5984 patients were identified. A pooled HR comparing the highest with the lowest category of circulating 25-OH-D levels under a fixed-effects model was 0.67 (95% confidence interval = 0.56-0.79, P < .001). Utilizing a dose-response meta-analysis, the pooled HR for overall survival in breast cancer patients was 0.994 (per 1 nmol/L), Pfor linear trend < .001. At or above a 23.3 nmol/L threshold, for a 10 nmol/L, 20 nmol/L, or 25 nmol/L increment in circulating 25-OH-D levels, the risk of breast cancer overall mortality decreased by 6%, 12%, and 14%, respectively. There was no significant nonlinearity in the relationship between overall survival and circulating 25-OH-D levels. Our findings suggest that there is a highly significant linear dose-response relationship between circulating 25-OH-D levels and overall survival in patients with breast cancer. However, better designed prospective cohort studies and clinical trials are needed to further confirm these findings.

scholarly journals Vitamin D pathway modulation in Caucasian case series of healthy women and breast cancer patients

2015 ◽  
Vol 26 ◽  
pp. vi19
Author(s):  
L. Mercatali ◽  
N. Masalu ◽  
A. Bongiovanni ◽  
A. Pangan ◽  
R. Tedaldi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Case Series ◽  
Breast Cancer Patients ◽  
Healthy Women

Prognostic characteristics of 492 newly diagnosed breast cancer patients by serum vitamin D levels.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12619-e12619 ◽  
Author(s):  
Luke Joseph Peppone ◽  
Mohamedtaki Abdulaziz Tejani ◽  
Karen Michelle Mustian ◽  
Michelle Christine Janelsins ◽  
Charles Stewart Kamen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Serum Vitamin ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Evalution of effect of Vitamin D levels and tumor Vitamin D receptor status as a risk factor and marker for therapeutic response Indian breast cancer patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12523-e12523
Author(s):  
Kul Ranjan Singh ◽  
Abhinav Arun Sonkar ◽  
Prarthana Saxena ◽  
Jitendra Kumar Kushwaha ◽  
Akshay Anand Agarwal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Risk Factor ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Therapeutic Response ◽  
Breast Cancer Patients ◽  
Receptor Status ◽  
Vitamin D Levels

scholarly journals Hubungan Kadar Vitamin D Plasma dengan Indeks Mitosis pada Pasien Kanker Payudara

2018 ◽  
Vol 1 (3) ◽  
pp. 143-148
Author(s):  
Astrid Siska Pratiwi ◽  
Yahwardiah Siregar
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Tumor Growth ◽  
Cancer Patients ◽  
Active Form ◽  
Plasma Vitamin ◽  
Breast Cancer Patients ◽  
Breast Cancer Outcome ◽  
Vitamin D Levels ◽  
Anatomical Pathology

Breast cancer is the most common cancer suffered by women and one of the biggest causes of death for women worldwide. Later, nutrition became one of the risk factors in breast cancer outcome, one of them is vitamin D. Calcitriol is the active form of vitamin D as an anti-proliferation, and  inhibits tumor growth. Uncontrolled proliferation is one of the characteristics of cancer cells. Tumor growth rates become prognostic markers that can be evaluated by correlating at cellular levels such as mitosis. The aimed of this study was to analyze the relationship between vitamin D levels and mitosis index in breast cancer patients. Research with cross sectional design gathered 50 breast cancer patients who were newly diagnosed and had never received chemotherapy. The study was conducted from January 2017 - August 2018 at the Department of Surgical Oncology, RSUPH. Adam Malik Medan. Examination of plasma vitamin D levels is done by ELISA technique at the Lab. Faculty of Medicine Universitas Sumatera Utara. The mitosis index data was obtained from the medical record of the research subjects reviewed by anatomical pathology specialists at the Lab. Anatomical Pathology of Faculty of Medicine Universitas Sumatera Utara. Statistical test uses Fisher Exact. The results of the study 48% of subjects had vitamin D sufficiency, 38% insufficiency and 14% had deficiency. The mean vitamin D levels in all of the study subjects were insufficiency (27.93ng / ml). In this study there was no significant relationship between plasma vitamin D levels and mitosis index in breast cancer patients p = 0.062. The insignificant relationship between vitamin D levels and mitotic index in this study shows that vitamin D not a single factors to influence the mitosis index in breast cancer patients.

scholarly journals Association of Serum Vitamin D Level and Vitamin D Receptor Expression among Newly Diagnosed Breast Cancer

2021 ◽  
Vol 50 (11) ◽  
pp. 3321-3332
Author(s):  
Hani Ajrina Zulkeflee ◽  
Tuan Salwani Tuan Ismail ◽  
Tengku Ahmad Damitri Al-Astani Tengku Din ◽  
Maya Mazuwin Yahya ◽  
Wan Faiziah Wan Abdul Rahman
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Healthy Volunteers ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Receptor Expression ◽  
Cancer Tissue ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Vitamin D Levels

There is a mushrooming interest in the anti-carcinogenic property of vitamin D. However, many researches reported a conflicting result in the association of vitamin D levels to certain types of cancer. This study was designed to assess the association between vitamin D and vitamin D receptor (VDR) expression with breast cancer. This case-control study, carried out at Hospital Universiti Sains Malaysia, Kelantan, involved 69 newly diagnosed breast cancer patients and 73 healthy volunteers. Serum 25(OH)D was taken and compared between 2 groups. VDR expression in patients’ breast tissue samples was determined by immunohistochemical staining method using anti-VDR antibody. 85.5% of breast cancer patients and 97.3% of healthy control were vitamin D insufficient with a mean (SD) of 13.36 (6.96) ng/mL and 13.05 (3.71) ng/mL, respectively, and the difference was not statistically significant. VDR expression showed cytoplasmic positivity in 75.4% of breast cancer tissue, followed by both cytoplasmic and nuclear positivity in 21.5% and complete absence in 3%. There was no significant association between VDR expression and hormone receptor status. In conclusion, there was a high prevalence of vitamin D deficiency among breast cancer and healthy volunteers in our study. There was no significant association between breast cancer and vitamin D. The VDR expression in breast cancer cells showed high cytoplasmic localization.

scholarly journals Hubungan kadar vitamin D plasma dengan IMT dan umur pada kanker payudara

2018 ◽  
Vol 3 (2) ◽  
pp. 117
Author(s):  
Zakirullah Syafei ◽  
Sri W Suryani ◽  
Denny S Rifsal
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Statistical Test ◽  
Plasma Vitamin ◽  
Test Results ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Vitamin D Levels

Breast cancer is the most common type of cancer in women worldwide. Statistics show breast cancer is the second leading cause of death after lung cancer. Vitamin D is believed to have anti-carcinogenic properties independently effective in protecting against breast cancer, biologically active vitamin D, can inhibit cell proliferation, induction of differentiation and apoptosis and inhibit angiogenesis in normal and malignant breast cells. Basal metabolic index (BMI) affects the bioavailability of vitamin D. Also the incidence of cancer increases with age, especially the age group> 40 years. The objective to analyze the relationship of plasma vitamin D levels with BMI and age in breast cancer. Method shaped analytic observational study with a cross-sectional design. A total of 53 outpatient breast cancer patients at Medan General Hospital were selected as study subjects using consecutive sampling technique. Serum 25 (OH) D testing used an enzyme-linked immunoabsorbent assay method. BMI data is obtained by measuring the body weight and height and age of the respondents' interviews. Data analysis used Spearman correlation statistical test. Results,  the mean vitamin D levels of the study subjects were 28,2 ± 8,9 ng / mL, BMI 25,5 ± 4,6 kg / m2, and subject age 51.1 ± 10,2 years. These results indicate normal vitamin D levels, a slightly high BMI and> 40 years of age. Statistical test results showed that there was a relatively weak relationship between plasma vitamin D levels and BMI (r = 0,2; p = 0,42) and age (r = 0,15; p = 0,86) breast cancer patients. Conclusion, there was no significant relationship between plasma vitamin D levels and the metabolic basal index and age in breast cancer patients.Kanker payudara merupakan jenis kanker yang paling umum terdapat pada wanita di seluruh dunia. Vitamin D memiliki sifat anti karsinogenik secara independen efektif dalam melindungi dari kanker payudara, secara biologis vitamin D aktif, dapat menghambat proliferasi sel, induksi deferensiasi dan apoptosis serta menghalangi angiogenesis pada sel payudara normal dan maligna. Indeks Masa Tubuh (IMT) berpengaruh terhadap bioavaibilitas vitamin D. Tujuan untuk menganalisis  hubungan kadar vitamin D plasma dengan IMT dan umur pada kanker payudara. Penelitian menggunakan studi observasional analitik dengan desain cross sectional. Sebanyak 53 pasien kanker payudara rawat jalan di RSUP-HAM Medan dipilih sebagai subjek penelitian menggunakan tehnik consecutive sampling. Pengujian serum 25(OH)D menggunakan metode enzyme-linked immunoabsorbent assay. Data IMT diperoleh dengan pengukuran berat badan dan tinggi badan serta umur dari hasil wawancara responden. Analisis data menggunakan uji statistik korelasi spearman.  Hasil, rerata kadar vitamin D subjek penelitian adalah 28,2±8,9 ng/mL, IMT 25,5±4,6 kg/m2, dan usia subjek 51,1±10,2 tahun. Hasil ini menunjukkan kadar vitamin D normal, IMT sedikit tinggi dan usia > 40 tahun. Hasil uji statistik, menunjukkan bahwa terdapat hubungan yang tergolong lemah antara kadar vitamin D plasma dengan IMT (r=0,2; p=0,42) dan usia (r=0,15; p=0,86) pasien kanker payudara. Kesimpulan, tidak terdapat hubungan yang signifikan antara kadar vitamin D plasma dengan indek masa tubuh dan usia  pada pasien kanker payudara.

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