scholarly journals Sex hormone levels and change in left ventricular structure among men and post-menopausal women: The Multi-Ethnic Study of Atherosclerosis (MESA)

Maturitas ◽  
2018 ◽  
Vol 108 ◽  
pp. 37-44 ◽  
Author(s):  
Vinita Subramanya ◽  
Di Zhao ◽  
Pamela Ouyang ◽  
Joao A. Lima ◽  
Dhananjay Vaidya ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Sex Hormone ◽  
Left Ventricular Structure ◽  
Hormone Levels ◽  
Ethnic Study ◽  
Ventricular Structure ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals COMMON GENETIC VARIANTS AND LEFT VENTRICULAR STRUCTURE IN THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS

2016 ◽  
Vol 67 (13) ◽  
pp. 1835
Author(s):  
Jose D. Vargas ◽  
Ani Manichaikul ◽  
Chia-Ying Liu ◽  
Stephen Rich ◽  
Wendy Post ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Left Ventricular ◽  
Left Ventricular Structure ◽  
Ethnic Study ◽  
Ventricular Structure ◽  
Common Genetic Variants

scholarly journals Association between Obstructive Sleep Apnea and Left Ventricular Structure by Age and Gender: the Multi-Ethnic Study of Atherosclerosis

SLEEP ◽  
2016 ◽  
Vol 39 (3) ◽  
pp. 523-529 ◽  
Author(s):  
Sogol Javaheri ◽  
Ravi K. Sharma ◽  
Rui Wang ◽  
Jia Weng ◽  
Boaz D. Rosen ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Left Ventricular ◽  
Age And Gender ◽  
Left Ventricular Structure ◽  
Ethnic Study ◽  
Ventricular Structure ◽  
Obstructive Sleep ◽  
And Gender

Abstract P054: Endogenous Sex Hormone Levels and Endothelial Function Among Men and Post-Menopausal Women in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Lena Mathews ◽  
Vinita Subramanya ◽  
Di Zhao ◽  
Pamela Ouyang ◽  
Dhanajay Vaidya ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Cvd Risk ◽  
Men And Women ◽  
Hormone Levels ◽  
Menopausal Women ◽  
Post Menopausal

Background: Sex is a major determinant of cardiovascular disease (CVD). Endogenous sex hormones exert a variety of effects on the vascular endothelium, and changes in sex hormone levels after menopause may play a role in CVD risk in women. We hypothesized that a more androgenic sex hormone profile among post-menopausal women, but not among men, would be associated with reduced blood flow-mediated vasodilation (FMD) of the brachial artery, a marker of worse endothelial function. Methods: We examined 1396 post-menopausal women and 1707 men participating in MESA, who were free of clinical CVD at baseline. Sex hormone levels [total testosterone (T), sex hormone binding globulin (SHBG), estradiol (E2)] were measured at Exam 1 (2000-02); free T and T/E2 ratio were calculated. FMD was measured by high-resolution ultrasound. Using multivariable adjusted Poisson and linear regression methods, we tested the cross-sectional associations of sex hormones (log transformed) with FMD. Results: The mean age of men and women was 61 and 64 years, respectively. Of women, 34% were using hormone therapy (HT). Among women, after adjusting for demographics, CVD risk factors, and HT use, higher SHBG was associated with higher FMD, whereas higher free T was associated with lower FMD (Table, Model 2). In women, when examining the “best FMD response” (top decile vs. bottom 9 deciles), higher E2 was positively associated with a prevalent best response, whereas higher free T was inversely associated. Among men, a higher T/E2 ratio was marginally associated with lower FMD. Conclusion: The association between sex hormones and FMD differs in men and women. Higher E2 and SHBG and lower free T levels were associated with better FMD in post-menopausal women but not in men. Higher T/E2 ratio was associated with lower FMD in men. Further studies are needed to assess longitudinal changes in sex hormone levels and their association with vascular aging. Sex hormone levels may help identify individuals at increased CVD risk who may benefit from other risk reduction strategies.

scholarly journals Association of number of live births with left ventricular structure and function. The Multi-Ethnic Study of Atherosclerosis (MESA)

2012 ◽  
Vol 163 (3) ◽  
pp. 470-476 ◽  
Author(s):  
Nisha I. Parikh ◽  
Donald M. Lloyd-Jones ◽  
Hongyan Ning ◽  
Pamela Ouyang ◽  
Joseph F. Polak ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Structure And Function ◽  
Left Ventricular Structure ◽  
Ethnic Study ◽  
Live Births ◽  
Ventricular Structure ◽  
And Function

Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice

2011 ◽  
Vol 301 (4) ◽  
pp. H1706-H1715 ◽  
Author(s):  
Igal A. Sebag ◽  
Marc-Antoine Gillis ◽  
Angelino Calderone ◽  
Amanda Kasneci ◽  
Melissa Meilleur ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Estrogen Receptor ◽  
Structure Function ◽  
Sex Hormones ◽  
Cpg Island ◽  
Left Ventricular ◽  
Sex Hormone ◽  
Calcium Flux ◽  
Left Ventricular Structure ◽  
Ventricular Structure

Calcium flux into and out of the sarco(endo)plasmic reticulum is vitally important to cardiac function because the cycle of calcium entry and exit controls contraction and relaxation. Putative estrogen and androgen consensus binding sites near to a CpG island are present in the cardiac calsequestrin 2 (CSQ2) promoter. Cardiomyocytes express sex hormone receptors and respond to sex hormones. We hypothesized that sex hormones control CSQ2 expression in cardiomyocytes and so affect cardiac structure/function. Echocardiographic analysis of male and female C57bl6n mice identified thinner walled and lighter hearts in females and significant concentric remodeling after long-term gonadectomy. CSQ2 and sodium-calcium exchanger-1 (NCX1) expression was significantly increased in female compared with male hearts and decreased postovariectomy. NCX1, but not CSQ2, expression was increased postcastration. CSQ2 expression was reduced when H9c2 cells were cultured in hormone-deficient media; increased when estrogen receptor-α (ERα), estrogen receptor-β (ERβ), or androgen agonists were added; and increased in hearts from ERβ-deficient mice. CSQ2 expression was reduced in mice fed a diet low in the methyl donor folic acid and in cells treated with 5-azadeoxycytidine suggesting an involvement of DNA methylation. DNA methylation in CpG in the CSQ2 CpG island was significantly different in males and females and was additionally changed postgonadectomy. Expression of DNA methyltransferases 1, 3a, and 3b was unchanged. These studies strongly link sex hormone-directed changes in CSQ2 expression to DNA methylation with changed expression correlated with altered left ventricular structure and function.

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