Seasonality of insulin resistance, glucose and insulin levels among middle-aged and elderly participants of the Rotterdam Study

Maturitas ◽  
2017 ◽  
Vol 103 ◽  
pp. 94
Author(s):  
Magda C. Cepeda Gil ◽  
Oscar Franco ◽  
Josje Schoufour
Keyword(s):  
Insulin Resistance ◽  
Rotterdam Study ◽  
Middle Aged ◽  
Insulin Levels

scholarly journals Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults

2012 ◽  
Vol 11 (1) ◽  
pp. 80 ◽  
Author(s):  
Toshitaka Muneyuki ◽  
Kei Nakajima ◽  
Atsushi Aoki ◽  
Masashi Yoshida ◽  
Hiroshi Fuchigami ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Plasma Insulin ◽  
Serum Amylase ◽  
Middle Aged ◽  
Insulin Levels ◽  
Plasma Insulin Levels ◽  
Middle Aged Adults ◽  
Low Serum

scholarly journals Surrogate Measures of Insulin Resistance in Middle-aged Non-diabetic Subjects

2013 ◽  
Vol 59 (6) ◽  
pp. 279-284
Author(s):  
Csép Katalin
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Fasting Insulin ◽  
Middle Aged ◽  
Insulin Levels ◽  
The Metabolic Syndrome ◽  
Sensitivity Indices ◽  
Increased Risk ◽  
Surrogate Measures

Abstract Objective: Insulin resistance has been shown to be a risk factor for type 2 diabetes and cardiovascular disease. The assessment of insulin sensitivity in the clinical practice, however, faces several difficulties. The study proposes to analyze surrogate measures of insulin resistance based on fasting insulin levels in central Romania, and check whether the diagnosis of the metabolic syndrome is an adequate strategy to identify middle-aged persons with reduced insulin sensitivity. Methods: Anthropometric measurements, metabolic profile, and surrogates measures of insulin sensitivity (GIR, HOMA, QUICKI, FIRI, Belfiore, Bennett, Raynaud, McAuley index) based on fasting insulin levels were assessed in 233 non-diabetic middle aged subjects. Results: Cutoff values, determined as the lowest quartile of insulin sensitivity for fasting insulin, HOMA, IRI (1/QUICKI), FIRI and Belfiore's, Bennett's, Raynaud's and McAuley's insulin sensitivity indices were 10.49 mU/L, 2.1, 3.01, 2.32, and 0.03, 1.34, 3.81, 6.29, 5.82. Components of the metabolic syndrome showed moderate but significant correlations with the surrogate measures of insulin resistance (r = 0.22-0.56, p <0.05). HOMA-IR and McAuley indices were the best predictors of clustered cardiometabolic risk factors (AUC - 0.83, 0.81 and 0.82). The metabolic syndrome diagnosis performed well in identifying patients with reduced insulin sensitivity (McAuley 2: sensitivity - 0.78, specificity - 0.84). Conclusion: Fasting insulin derived insulin sensitivity indices may help the recognittion of insulin resistant states predicting cardiometabolic disorders. Actively looking for insulin resistance by these simple indices, or by diagnosing the metabolic syndrome, those at increased risk can be recognized

scholarly journals Seasonality of Insulin Resistance, Glucose, and Insulin Among Middle-Aged and Elderly Population: The Rotterdam Study

2017 ◽  
Vol 103 (3) ◽  
pp. 946-955 ◽  
Author(s):  
Magda Cepeda ◽  
Taulant Muka ◽  
M Arfan Ikram ◽  
Oscar H Franco ◽  
Josje D Schoufour
Keyword(s):  
Insulin Resistance ◽  
Elderly Population ◽  
Rotterdam Study ◽  
Middle Aged

scholarly journals Body mass index and waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged and elderly Taiwanese

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8126 ◽  
Author(s):  
Yiu-Hua Cheng ◽  
Yu-Chung Tsao ◽  
I-Shiang Tzeng ◽  
Hai-Hua Chuang ◽  
Wen-Cheng Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Middle Aged ◽  
Fat Percentage ◽  
Total Body Fat ◽  
Total Body

scholarly journals Insulin resistance predicts brain amyloid deposition in late middle-aged adults

2014 ◽  
Vol 11 (5) ◽  
pp. 504-510.e1 ◽  
Author(s):  
Auriel A. Willette ◽  
Sterling C. Johnson ◽  
Alex C. Birdsill ◽  
Mark A. Sager ◽  
Bradley Christian ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Amyloid Deposition ◽  
Middle Aged ◽  
Middle Aged Adults ◽  
Brain Amyloid Deposition

Dermatological screening of a middle-aged and elderly population: the Rotterdam Study

2017 ◽  
Vol 177 (4) ◽  
pp. e98-e100 ◽  
Author(s):  
M.G.H. Sanders ◽  
L.M. Pardo ◽  
J.A.C. Verkouteren ◽  
S.A.S. Hamann ◽  
M.A. Hamer ◽  
...  
Keyword(s):  
Elderly Population ◽  
Rotterdam Study ◽  
Middle Aged

scholarly journals Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome

2016 ◽  
Vol 7 (8) ◽  
pp. 3390-3401 ◽  
Author(s):  
Damiana D. Rosa ◽  
Łukasz M. Grześkowiak ◽  
Célia L. L. F. Ferreira ◽  
Ana Carolina M. Fonseca ◽  
Sandra A. Reis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Animal Model ◽  
Inflammatory Cytokine ◽  
Fasting Glucose ◽  
Cytokine Expression ◽  
Fasting Insulin ◽  
Insulin Levels ◽  
Reduce Insulin Resistance

Kefir supplementation in rats with induced metabolic syndrome was able to lower fasting glucose, fasting insulin levels, and reduce insulin resistance.

Rosemary Extract Activates AMPK, Inhibits mTOR and Attenuates the High Glucose and High Insulin-Induced Muscle Cell Insulin Resistance

2021 ◽  
Author(s):  
Hesham Shamshoum ◽  
Filip Vlavcheski ◽  
Rebecca E.K. MacPherson ◽  
Evangelia Tsiani
Keyword(s):  
Insulin Resistance ◽  
Plasma Membrane ◽  
Blood Glucose ◽  
Glucose Uptake ◽  
Muscle Cell ◽  
High Glucose ◽  
Serine Phosphorylation ◽  
Rosemary Extract ◽  
Insulin Levels ◽  
High Insulin

Impaired action of insulin in skeletal muscle, termed insulin resistance, leads to increased blood glucose levels resulting in compensatory increase in insulin levels. The elevated blood glucose and insulin levels exacerbate insulin resistance and contribute to the pathogenesis of type 2 diabetes mellitus (T2DM). In previous studies we found attenuation of free fatty acid-induced muscle cell insulin resistance by rosemary extract (RE). In the present study we investigated the effects of RE on high glucose (HG) and high insulin (HI)-induced muscle cell insulin resistance. Exposure of L6 myotubes to 25 mM glucose and 100 nM insulin for 24 h, to mimic hyperglycemia and hyperinsulinemia, abolished the acute insulin-stimulated glucose uptake, increased the serine phosphorylation of IRS-1 and the phosphorylation/ activation of mTOR and p70S6K. Treatment with RE significantly improved the insulin-stimulated glucose uptake and increased the acute insulin-stimulated tyrosine phosphorylation while reduced the HG+HI-induced serine phosphorylation of IRS-1 and phosphorylation of mTOR and p70S6K. Additionally, treatment with RE significantly increased the phosphorylation of AMPK, its downstream effector ACC and the plasma membrane GLUT4 levels. Our data indicate a potential of RE to counteract muscle cell insulin resistance and more studies are required to investigate its effectiveness in vivo. Novelty: • Rosemary extract (RE) phosphorylated muscle cell AMPK and ACC under both normal and high glucose (HG)/high insulin (HI) conditions. • The HG/HI-induced serine phosphorylation of IRS-1 and activation of mTOR and p70S6K were attenuated by RE. • RE increased the insulin-stimulated glucose uptake by enhancing GLUT4 glucose transporter translocation to plasma membrane.

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