Insulin growth factor (IGF) 1, IGF-binding proteins and ovarian cancer risk: A systematic review and meta-analysis

Maturitas ◽  
2016 ◽  
Vol 94 ◽  
pp. 22-29 ◽  
Author(s):  
Ximena Gianuzzi ◽  
Gabriela Palma-Ardiles ◽  
Wendy Hernandez-Fernandez ◽  
Vinay Pasupuleti ◽  
Adrian V. Hernandez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Binding Proteins ◽  
Meta Analysis ◽  
Ovarian Cancer Risk ◽  
Igf Binding Proteins ◽  
Insulin Growth Factor ◽  
Igf Binding

scholarly journals Circulating Insulin-Like Growth Factor-1 Level and Ovarian Cancer Risk

2016 ◽  
Vol 38 (2) ◽  
pp. 589-597 ◽  
Author(s):  
Yiyang Li ◽  
Yang Li ◽  
Jialing Zhang ◽  
Changjun Zheng ◽  
He Zhu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Ovarian Cancer Risk ◽  
Insulin Like Growth Factor ◽  
Summary Odds Ratio

Background/Aims: Insulin-like growth factor-1 (IGF-1) has an important role in cells' proliferation, differentiation and apoptosis, and it may be involved in carcinogenesis. Several epidemiological studies assessed the association between circulating IGF-1 level and ovarian cancer risk, but there was still no conclusive finding. Methods: A meta-analysis of published studies was performed to assess the association between circulating IGF-1 level and ovarian cancer risk. The summary odds ratio (OR) with 95% confidence interval (95%CI) was calculated through meta-analysis to evaluate the strength of the association. Results: Five eligible studies were included into the meta-analysis, which involved a total of 2,028 cases of ovarian cancer and 4,625 controls. Meta-analysis of total 5 studies showed that high circulating IGF-1 level was correlated with decreased risk of ovarian cancer (OR = 0.84, 95%CI 0.74-0.97, P = 0.013). After adjusting for heterogeneity, high circulating IGF-1 level was still correlated with decreased risk of ovarian cancer (OR = 0.83, 95%CI 0.72-0.95, P = 0.007). Subgroup analysis by age showed that circulating IGF-1 level was not correlated with ovarian cancer risk in women both less than 55 years and more than 55 years. However, after adjusting for heterogeneity, high circulating IGF-1 level was correlated with decreased ovarian cancer risk in women less than 55 years (OR = 0.82, 95%CI 0.72-0.94, P = 0.004). Conclusion: Our meta-analysis suggests that high circulating IGF-1 level may be correlated with decreased ovarian cancer risk, especially in women less than 55 years. More studies are needed to further assess the association between circulating IGF-1 level and ovarian cancer risk in the future.

scholarly journals A prospective study of insulin-like growth factor-I, IGF-binding proteins-1, -2 and -3 and lung cancer risk in women

2001 ◽  
Vol 92 (6) ◽  
pp. 888-892 ◽  
Author(s):  
Annekatrin Lukanova ◽  
Paolo Toniolo ◽  
Arslan Akhmedkhanov ◽  
Carine Biessy ◽  
Nancy J. Haley ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prospective Study ◽  
Binding Proteins ◽  
Lung Cancer Risk ◽  
Igf Binding Proteins ◽  
Factor I ◽  
Igf Binding ◽  
A Prospective Study

Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis

2012 ◽  
Vol 125 (3) ◽  
pp. 758-763 ◽  
Author(s):  
Matteo Rota ◽  
Elena Pasquali ◽  
Lorenza Scotti ◽  
Claudio Pelucchi ◽  
Irene Tramacere ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Epithelial Ovarian Cancer ◽  
Alcohol Drinking ◽  
Meta Analysis ◽  
Ovarian Cancer Risk

scholarly journals Anthropometric factors and ovarian cancer risk: A systematic review and nonlinear dose-response meta-analysis of prospective studies

2014 ◽  
Vol 136 (8) ◽  
pp. 1888-1898 ◽  
Author(s):  
Dagfinn Aune ◽  
Deborah A. Navarro Rosenblatt ◽  
Doris Sau Man Chan ◽  
Leila Abar ◽  
Snieguole Vingeliene ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Ovarian Cancer Risk

scholarly journals Breastfeeding and Ovarian Cancer Risk: a Systematic Review and Meta-analysis of 40 Epidemiological Studies

2014 ◽  
Vol 15 (12) ◽  
pp. 4829-4837 ◽  
Author(s):  
Da-Peng Li ◽  
Chen Du ◽  
Zuo-Ming Zhang ◽  
Guang-Xiao Li ◽  
Zhi-Fu Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Ovarian Cancer Risk

scholarly journals Sedentary behaviour in relation to ovarian cancer risk: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Veronika S. Biller ◽  
Michael F. Leitzmann ◽  
Anja M. Sedlmeier ◽  
Felix F. Berger ◽  
Olaf Ortmann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Sensitivity Analysis ◽  
Cancer Risk ◽  
Sedentary Behaviour ◽  
Meta Analysis ◽  
Case Control ◽  
Ovarian Cancer Risk ◽  
Case Control Studies ◽  
Prospective Cohort Studies

AbstractSedentary behaviour is an emerging risk factor for several site-specific cancers. Ovarian cancers are often detected at late disease stages and the role of sedentary behaviour as a modifiable risk factor potentially contributing to ovarian cancer risk has not been extensively examined. We systematically searched relevant databases from inception to February 2020 for eligible publications dealing with sedentary behaviour in relation to ovarian cancer risk. We conducted a systematic review and meta-analysis, calculating summary relative risks (RR) and 95% confidence intervals (CI) using a random-effects model. We calculated the E-Value, a sensitivity analysis for unmeasured confounding. We tested for publication bias and heterogeneity. Seven studies (three prospective cohort studies and four case–control studies) including 2060 ovarian cancer cases were analysed. Comparing highest versus lowest levels of sedentary behaviour, the data indicated a statistically significant increase in the risk of ovarian cancer in relation to prolonged sitting time (RR = 1.29, 95% CI = 1.07–1.57). Sub-analyses of prospective cohort studies (RR = 1.33, 95% CI = 0.92–1.93) and case–control studies (RR = 1.28, 95% CI = 0.98–1.68) showed statistically non-significant results. Sensitivity analysis showed that an unmeasured confounder would need to be related to sedentary behaviour and ovarian cancer with a RR of 1.90 to fully explain away the observed RR of 1.29. Our analyses showed a statistically significant positive association between sedentary behaviour and ovarian cancer risk.

scholarly journals Meat, fish, and ovarian cancer risk: results from 2 Australian case-control studies, a systematic review, and meta-analysis

2010 ◽  
Vol 91 (6) ◽  
pp. 1752-1763 ◽  
Author(s):  
Fariba Kolahdooz ◽  
Jolieke C van der Pols ◽  
Christopher J Bain ◽  
Geoffrey C Marks ◽  
Maria Celia Hughes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Ovarian Cancer Risk ◽  
Case Control Studies ◽  
Australian Case
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