Over-the-counter anti-ageing topical agents and their ability to protect and repair photoaged skin

Maturitas ◽  
2015 ◽  
Vol 80 (3) ◽  
pp. 265-272 ◽  
Author(s):  
Eleanor J. Bradley ◽  
Christopher E.M. Griffiths ◽  
Michael J. Sherratt ◽  
Mike Bell ◽  
Rachel E.B. Watson
Keyword(s):  
Over The Counter ◽  
Photoaged Skin

Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

1987 ◽  
Vol 45 ◽  
pp. 718-719
Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat
Keyword(s):  
Low Dose ◽  
Fetal Liver ◽  
Late Pregnancy ◽  
Toxic Chemicals ◽  
Control Group ◽  
High Dose ◽  
Over The Counter ◽  
Liver And Kidney ◽  
Neonatal Liver ◽  
Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

Human Psychopharmacology and Dose-Effects of Dextromethorphan, an NMDA Antagonist Hallucinogen Present in Over-the-Counter Cough Medications

2011 ◽  
Author(s):  
Lawrence P. Carter ◽  
Chad R. Reissig ◽  
Miriam Z. Mintzer ◽  
Matthew W. Johnson ◽  
Roland R. Griffiths
Keyword(s):  
Nmda Antagonist ◽  
Over The Counter ◽  
Dose Effects ◽  
Human Psychopharmacology
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