Insulin resistance, obesity and breast cancer risk

Maturitas ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 19-30 ◽  
Author(s):  
C. Pichard ◽  
G. Plu-Bureau ◽  
M. Neves-e Castro ◽  
A. Gompel
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Cancer Risk ◽  
Cancer Risk

scholarly journals Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors

2018 ◽  
Vol 15 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sheri J. Hartman ◽  
Catherine R. Marinac ◽  
Lisa Cadmus-Bertram ◽  
Jacqueline Kerr ◽  
Loki Natarajan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Survivors ◽  
Sedentary Behavior ◽  
Breast Cancer Survivors ◽  
Sitting Time ◽  
Sedentary Behaviors ◽  
Sit To Stand

Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = −5.52; 95% CI, −9.79 to −1.24) and a lower HOMA-IR value (β = −0.22; 95% CI, −0.42 to −0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.

scholarly journals Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0136240 ◽  
Author(s):  
Catherine R. Marinac ◽  
Dorothy D. Sears ◽  
Loki Natarajan ◽  
Linda C. Gallo ◽  
Caitlin I. Breen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Circadian Timing

The Effect of Insulin Resistance on Breast Cancer Risk in Latinas of Mexican Origin

2014 ◽  
Vol 12 (9) ◽  
pp. 477-483 ◽  
Author(s):  
Hid Felizardo Cordero-Franco ◽  
Ana María Salinas-Martínez ◽  
Alberto Abundis ◽  
Eva María Espinosa-Flores ◽  
Julia Vázquez-Lara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mexican Origin

scholarly journals The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study

2008 ◽  
Vol 113 (3) ◽  
pp. 567-576 ◽  
Author(s):  
Anne E. Cust ◽  
Tanja Stocks ◽  
Annekatrin Lukanova ◽  
Eva Lundin ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Prospective Study ◽  
Stage At Diagnosis ◽  
Tumour Stage ◽  
A Prospective Study
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