Mechanical characterization of optical glass fiber coated with a thin film of silver nanoparticles by nanoindentation

2014 ◽  
Vol 136 ◽  
pp. 63-66 ◽  
Author(s):  
A. Nevarez-Rascon ◽  
E. Orrantia-Borunda ◽  
J. González-Hernández ◽  
S. Flores-Gallardo ◽  
A. Hurtado-Macías
Keyword(s):  
Thin Film ◽  
Silver Nanoparticles ◽  
Glass Fiber ◽  
Mechanical Characterization ◽  
Optical Glass ◽  
Optical Glass Fiber

scholarly journals A Novel Diagnostic Test for End-Stage Sensory Failure Associated With Diabetic Foot Ulceration: Proof-of-Principle Study

2020 ◽  
pp. 193229681990025
Author(s):  
Ernst-Adolf Chantelau
Keyword(s):  
Glass Fiber ◽  
Likelihood Ratio ◽  
Diabetic Foot ◽  
Pain Perception ◽  
Rating Scale ◽  
Optical Glass ◽  
Positive Likelihood Ratio ◽  
Foot Ulceration ◽  
End Stage ◽  
Optical Glass Fiber

Background: Diabetic foot ulceration (DFU) affects only a subgroup of patients with diabetic neuropathy, that is, those with pain-insensitivity due to end-stage sensory failure. Pain perception failure develops insidiously and remains asymptomatic until first DFU. As loss of pain perception is clinically significant, timely detection is mandatory. Objectives: A novel suprathreshold pinprick pain stimulus of 512 mN force made from optical glass-fiber was explored in a prospective cross-sectional diagnostic accuracy study to detect DFU-related end-stage sensory failure. Methods: A total of 116 participants were studied (25 healthy people, 22 patients with diabetes without relevant complications, 19 patients with previous painful foot or leg injuries, and 50 patients with previous or active painless DFU [reference standard]). Palmar and plantar surfaces were stimulated in a standardized fashion. At the feet, the second and third toe skinfolds and the middle of the plantar arch were stimulated. Participants scored stimulated pricking discomfort or pain intensity 0 to 10 on a numerical rating scale. Results: At hands, intensity was rated on average 5 (1-10) [median (range)] by 114/116 participants. Per foot, participants without DFU scored 5 (1-10), while those with DFU scored 0 (0-3) ( P < .0001). At plantar toe skinfolds, the absence of pinprick pain perception detected DFU-associated sensory failure with an accuracy of 99.5% (sensitivity 99.5%, specificity 99.4%, positive likelihood ratio 248, and negative likelihood ratio 0.005). Conclusion: In this pilot study, nociceptive stimulation of a plantar toe skinfold with a 512 mN optical glass-fiber pinprick accurately identified DFU-associated end-stage sensory failure.

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