Stable water-soluble iron oxide nanoparticles using Tiron

2013 ◽  
Vol 138 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Katalin V. Korpany ◽  
Fatemah Habib ◽  
Muralee Murugesu ◽  
Amy Szuchmacher Blum
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Soluble Iron

Formation of Water-Soluble Iron Oxide Nanoparticles Derived from Iron Storage Protein

2004 ◽  
Vol 4 (7) ◽  
pp. 708-711 ◽  
Author(s):  
Masato Tominaga ◽  
Li Han ◽  
Lingyan Wang ◽  
Mathew M. Maye ◽  
Jin Luo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Storage Protein ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Iron Storage ◽  
Soluble Iron ◽  
Iron Storage Protein

Water-Soluble Iron Oxide Nanoparticles with High Stability and Selective Surface Functionality

Langmuir ◽  
2011 ◽  
Vol 27 (14) ◽  
pp. 8990-8997 ◽  
Author(s):  
Yaolin Xu ◽  
Ying Qin ◽  
Soubantika Palchoudhury ◽  
Yuping Bao
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
High Stability ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Soluble Iron ◽  
Surface Functionality

Water-Soluble Anisotropic Iron Oxide Nanoparticles: Dextran-Coated Crystalline Nanoplates and Nanoflowers

2014 ◽  
Vol 32 (3) ◽  
pp. 224-233 ◽  
Author(s):  
Soubantika Palchoudhury ◽  
Fahmeed Hyder ◽  
T. Kyle Vanderlick ◽  
Nienke Geerts
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Water Soluble ◽  
Oxide Nanoparticles

Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 99948-99959 ◽  
Author(s):  
Ganeshlenin Kandasamy ◽  
Sreeraj Surendran ◽  
Anindita Chakrabarty ◽  
S. N. Kale ◽  
Dipak Maity
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Amine Functionalized ◽  
One Step ◽  
Cancer Theranostics

We report a one-step facile synthesis of novel water-soluble and functionalized SPIONs, which could be promising candidates for cancer theranostics.

Continuous growth phenomenon for direct synthesis of monodisperse water-soluble iron oxide nanoparticles with extraordinarily high relaxivity

Nanoscale ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 9272-9283 ◽  
Author(s):  
Pohlee Cheah ◽  
Terriona Cowan ◽  
Rong Zhang ◽  
Ali Fatemi-Ardekani ◽  
Yongjian Liu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Direct Synthesis ◽  
Size Control ◽  
Water Soluble ◽  
Nanometer Scale ◽  
Oxide Nanoparticles ◽  
Continuous Growth ◽  
High Relaxivity ◽  
Growth Phenomenon

A continuous growth phenomenon is discovered for the synthesis of iron oxide nanoparticles with nanometer-scale size control in an amphiphilic solvent. The as-prepared nanoparticles are extremely water soluble without any surface modification.

scholarly journals Supramolecular Surface Functionalization of Iron Oxide Nanoparticles with α-Cyclodextrin-Based Cationic Star Polymer for Magnetically-Enhanced Gene Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1884
Author(s):  
Hanyi Li ◽  
Erwin Peng ◽  
Feng Zhao ◽  
Jun Li ◽  
Junmin Xue
Keyword(s):  
Iron Oxide ◽  
Gene Delivery ◽  
Iron Oxide Nanoparticles ◽  
Mammalian Cells ◽  
Gene Transfection ◽  
Functional Materials ◽  
Water Soluble ◽  
Star Polymer ◽  
Viral Gene ◽  
Oxide Nanoparticles

Supramolecular polymers formed through host–guest complexation have inspired many interesting developments of functional materials for biological and biomedical applications. Here, we report a novel design of a non-viral gene delivery system composed of a cationic star polymer forming supramolecular complexes with the surface oleyl groups of superparamagnetic iron oxide nanoparticles (SPIONs), for magnetically enhanced delivery of DNA into mammalian cells. The cationic star polymer was synthesized by grafting multiple oligoethylenimine (OEI) chains onto an α-cyclodextrin (α-CD) core. The SPIONs were synthesized from iron(III) acetylacetonate and stabilized by hydrophobic oleic acid and oleylamine in hexane, which were characterized in terms of their size, structure, morphology, and magnetic properties. The synthesized magnetic particles were found to be superparamagnetic, making them a suitable ferrofluid for biological applications. In order to change the hydrophobic surface of the SPIONs to a hydrophilic surface with functionalities for plasmid DNA (pDNA) binding and gene delivery, a non-traditional but simple supramolecular surface modification process was used. The α-CD-OEI cationic star polymer was dissolved in water and then mixed with the SPIONs stabilized in hexane. The SPIONs were “pulled” into the water phase through the formation of supramolecular host–guest inclusion complexes between the α-CD unit and the oleyl surface of the SPIONs, while the surface of the SPIONs was changed to OEI cationic polymers. The α-CD-OEI-SPION complex could effectively bind and condense pDNA to form α-CD-OEI-SPION/pDNA polyplex nanoparticles at the size of ca. 200 nm suitable for delivery of genes into cells through endocytosis. The cytotoxicity of the α-CD-OEI-SPION complex was also found to be lower than high-molecular-weight polyethylenimine, which was widely studied previously as a standard non-viral gene vector. When gene transfection was carried out in the presence of an external magnetic field, the α-CD-OEI-SPION/pDNA polyplex nanoparticles greatly increased the gene transfection efficiency by nearly tenfold. Therefore, the study has demonstrated a facile two-in-one method to make the SPIONs water-soluble as well as functionalized for enhanced magnetofection.

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