Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans

2012 ◽  
Vol 133 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Tabitha Tonsaker ◽  
Ryan M. Pratt ◽  
James D. McGhee
Keyword(s):  
Transcription Factor ◽  
C Elegans ◽  
Gata Transcription Factor

Tricho-Rhino-Phalangeal Syndrome with Supernumerary Teeth

2008 ◽  
Vol 87 (11) ◽  
pp. 1027-1031 ◽  
Author(s):  
P. Kantaputra ◽  
I. Miletich ◽  
H.-J. Lüdecke ◽  
E.Y. Suzuki ◽  
V. Praphanphoj ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Amino Acid ◽  
Zinc Finger ◽  
Clinical Features ◽  
Tooth Development ◽  
Supernumerary Teeth ◽  
Gene Encoding ◽  
Gata Transcription Factor ◽  
Craniofacial Defects

Tricho-rhino-phalangeal syndromes (TRPS) are caused by mutation or deletion of TRPS1, a gene encoding a GATA transcription factor. These disorders are characterized by abnormalities of the hair, face, and selected bones. Rare cases of individuals with TRPS displaying supernumerary teeth have been reported, but none of these has been examined molecularly. We used two different approaches to investigate a possible role of TRPS1 during tooth development. We looked at the expression of Tprs1 during mouse tooth development and analyzed the craniofacial defects of Trps1 mutant mice. In parallel, we investigated whether a 17-year-old Thai boy with clinical features of TRPS and 5 supernumerary teeth had mutation in TRPS1. We report here that Trps1 is expressed during mouse tooth development, and that an individual with TRPS with supernumerary teeth has the amino acid substitution A919V in the GATA zinc finger of TRPS1. These results suggest a role for TRPS1 in tooth morphogenesis.

scholarly journals Examining the role of SUMOylation in C. elegans T-box transcription factor TBX-2 function

2011 ◽  
Vol 356 (1) ◽  
pp. 261
Author(s):  
Paul Huber ◽  
Tanya Crum ◽  
Peter Okkema
Keyword(s):  
Transcription Factor ◽  
T Box ◽  
C Elegans

scholarly journals Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans

PLoS Genetics ◽  
2016 ◽  
Vol 12 (4) ◽  
pp. e1005956 ◽  
Author(s):  
Frederick G. Mann ◽  
Eric L. Van Nostrand ◽  
Ari E. Friedland ◽  
Xiao Liu ◽  
Stuart K. Kim
Keyword(s):  
Transcription Factor ◽  
Normal Aging ◽  
C Elegans ◽  
Gata Transcription Factor

scholarly journals Expression Pattern, Regulation, and Biological Role of Runt Domain Transcription Factor, run, in Caenorhabditis elegans

2002 ◽  
Vol 22 (2) ◽  
pp. 547-554 ◽  
Author(s):  
Seunghee Nam ◽  
Yun-Hye Jin ◽  
Qing-Lin Li ◽  
Kwang-Youl Lee ◽  
Goo-Bo Jeong ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Essential Role ◽  
Regulatory Elements ◽  
Intestinal Cells ◽  
Human Leukemia ◽  
Runt Domain ◽  
C Elegans ◽  
Intron Region

ABSTRACT The Caenorhabditis elegans run gene encodes a Runt domain factor. Runx1, Runx2, and Runx3 are the three known mammalian homologs of run. Runx1, which plays an essential role in hematopoiesis, has been identified at the breakpoint of chromosome translocations that are responsible for human leukemia. Runx2 plays an essential role in osteogenesis, and inactivation of one allele of Runx2 is responsible for the human disease cleidocranial dysplasia. To understand the role of run in C. elegans, we used transgenic run::GFP reporter constructs and a double-stranded RNA-mediated interference method. The expression of run was detected as early as the bean stage exclusively in the nuclei of seam hypodermal cells and lasted until the L3 stage. At the larval stage, expression of run was additionally detected in intestinal cells. The regulatory elements responsible for the postembryonic hypodermal seam cells and intestinal cells were separately located within a 7.2-kb-long intron region. This is the first report demonstrating that an intron region is essential for stage-specific and cell type-specific expression of a C. elegans gene. RNA interference analysis targeting the run gene resulted in an early larva-lethal phenotype, with apparent malformation of the hypodermis and intestine. These results suggest that run is involved in the development of a functional hypodermis and gut in C. elegans. The highly conserved role of the Runt domain transcription factor in gut development during evolution from nematodes to mammals is discussed.

scholarly journals Caenorhabditis eleganssensory neurons modulate pathogen specific responses via HLH-30/TFEB transcription factor and FSHR-1 GPCR axes of immunity

2019 ◽  
Author(s):  
Anjali Gupta ◽  
Manoj Varma ◽  
Varsha Singh
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Transcription Factor ◽  
Sensory Perception ◽  
Immune Effector ◽  
C Elegans ◽  
Classical Pattern ◽  
Molecular Patterns ◽  
Ciliated Neurons

ABSTRACTPattern recognition receptors allow animals to sense microbe associated molecular patterns and mount effective immune responses. It is not clear howCaenorhabditis elegansrecognizes pathogenic microbes in absence of classical pattern recognition pathways. Here, we asked if sensory neurons ofC. elegansallow it to distinguish between pathogens. Exposure ofC. elegansto a Gram positive bacteriumEnterococcus faecalisor to a Gram negative bacteriumPseudomonas aeruginosashowed predominantly pathogen-specific signatures. Using nematodes defective in sensory perception, we show that neuronal sensing is essential to mount pathogen specific immune response. OSM-6 expressing, ciliated neurons exert non-cell autonomous control of immune effector production via an OSM-6-FSHR-1 GPCR axis as well as an OSM-6-HLH-30/TFEB transcription factor axis duringE. faecalisinfection. OSM-6-FSHR-1 axis also controls immune response toP. aeruginosa. In all, this study delineates essential role of sensory perception in the regulation of pathogen-specific immunity inC. elegans.

scholarly journals The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.

2019 ◽  
Author(s):  
Patrycja Chudzicka-Ormaniec ◽  
Maria Macios ◽  
Michał Koper ◽  
Gareth D Weedall ◽  
Mark X Caddick ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Aspergillus Nidulans ◽  
Carbon Metabolism ◽  
Gata Transcription Factor

scholarly journals The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains

2020 ◽  
Vol 16 (9) ◽  
pp. e1008826
Author(s):  
Alejandra Zárate-Potes ◽  
Wentao Yang ◽  
Barbara Pees ◽  
Rebecca Schalkowski ◽  
Philipp Segler ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Bacillus Thuringiensis ◽  
Transcriptional Responses ◽  
C Elegans ◽  
Gata Transcription Factor
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