scholarly journals Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

2011 ◽  
Vol 132 (11-12) ◽  
pp. 560-567 ◽  
Author(s):  
Aderbal S. Aguiar ◽  
Adalberto A. Castro ◽  
Eduardo L. Moreira ◽  
Viviane Glaser ◽  
Adair R.S. Santos ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory ◽  
Aging Rats ◽  
Hippocampal Plasticity ◽  
Bdnf Signaling

scholarly journals Spatial learning and memory of young and aging rats following injection with human Wharton’s jelly‐mesenchymal stem cells

2021 ◽  
Vol 26 (2) ◽  
pp. 91
Author(s):  
Berry Juliandi ◽  
Wildan Mubarok ◽  
Dian Anggraini ◽  
Arief Boediono ◽  
Mawar Subangkit ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Neuronal Apoptosis ◽  
Spatial Learning And Memory ◽  
Post Injection ◽  
Aging Rats ◽  
Wharton's Jelly ◽  
Young Rats

Human Wharton’s jelly‐mesenchymal stem cells (hWJ‐MSC) are an emerging potential source of stem cells derived from the umbilical cord. Previous studies have shown their potential as treatment for traumatic brain injury and Parkinson’s disease. However, no study has yet investigated the effect of hWJ‐MSC injections in countering spatial learning and memory impairment in aging rats. The effect of hWJ‐MSC injection on young rats is also unknown. The objective of this research was to analyze the effect of an hWJ‐MSC injection on spatial learning, memory, density of putative neural progenitor cells (pNPC), and neuronal apoptosis in the dentate gyrus (DG) of young and aging rats. Injection of hWJ‐MSC did not change spatial learning and memory in young rats until two months post‐injection. This might be due to retained pNPC density and neuronal apoptosis in the DG of young rats after injection of hWJ‐MSC. In contrast, injection of hWJ‐MSC promoted both spatial learning and memory in aging rats, a finding that might be attributable to the increased pNPC density and attenuated neuronal apoptosis in DG of aging rats during the two months post‐injection. Our study suggests that a single injection of hWJ‐MSC might be sufficient to promote improvement in long‐term learning and memory in aging rats.

scholarly journals A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory

2009 ◽  
Vol 41 (4) ◽  
pp. 409-419 ◽  
Author(s):  
Ursula Haditsch ◽  
Dino P. Leone ◽  
Mélissa Farinelli ◽  
Anna Chrostek-Grashoff ◽  
Cord Brakebusch ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Small Gtpase ◽  
Spatial Learning And Memory ◽  
Hippocampal Plasticity

Physical exercise, neuroplasticity, spatial learning and memory

2015 ◽  
Vol 73 (5) ◽  
pp. 975-983 ◽  
Author(s):  
Ricardo C. Cassilhas ◽  
Sergio Tufik ◽  
Marco Túlio de Mello
Keyword(s):  
Physical Exercise ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory

scholarly journals PO-216 The Effects of Aerobic Exercise on Spatial Learning and Memory and Expression of PDE-4 in Hippocampus of the Aging Rats

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Xue Li ◽  
Shuling Zhang ◽  
Lu Wang
Keyword(s):  
Cerebral Cortex ◽  
Aerobic Exercise ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Hippocampal Neurons ◽  
Exercise Intervention ◽  
Brain Aging ◽  
Morphological Structure ◽  
Spatial Learning And Memory ◽  
Aging Rats

Objective To discuss the effect of aerobic exercise intervention before aging rats and on aging rats, the spatial learning and memory abilities and the expression of PDE-4 in hippocampus. Methods 64 male SD rats were divided into 4 groups at random (n=16): control group(group C), D-galactose aging model group (group A), Pre-aging aerobic exercise intervention group (group S1), Aerobic exercise intervention on aging group (group S2). After 6 weeks, each group was randomly divided into Morris water maze behavior training group (M group) and natural feeding group (N group), record as CM, AM, S1M, S2M, CN, AN, S1N, S2N. At the end of 7th week, all rats were killed and the cerebral cortex SOD, GSH-PX and MDA content were tested; The expression of PDE-4 gene in hippocampus was detected by Real-time PCR and Western blotting. Results 1) The general state: When compared to the rats in C group, which in A group show obvious symptoms of aging, such as lethargy, loss of appetite, slow, yellow curly hair color, even off signs and so on; but S2 group were similar to C group; S1 group were a little worse than S2 group. 2) HE staining: When compared to the rats in C group, the hippocampus neurons in A group were disordered, the cells staining were deepened, the cytoplasm were edema, most of the interstitial cells were loose, and other morphological structure in aging state;S2 group were similar to C group; S1 group were a little worse than S2 group.3) The free radical detection: Almost no difference in each corresponding M group and N group. The activities of the cerebral cortex SOD and GSH-PX in were consistent: C group and S2group were significantly or very significantly higher than others (P<0.05/0.01); The cerebral cortex MDA content: C group was the lowest, S2 group followed, and all significantly lower than those in A group and S1 group (P<0.05). 4)The Morris water maze test: the Positioning navigation experiment results showed that the spatial memory was preliminarily formed on the day 2, CM group, S1M group and S2M group formed stable spatial learning and memory on day 3,but that of AM group formed on day 4; The space exploration test results showed that the maximum number of times of through the site was CM group, the percentage of the original site quadrant of CM group was the highest, and there was a very significant difference with the other groups (P<0.01); S2 group followed, but AM group and S1M were relatively low. 5)The results of Real-time PCR and Western blotting: When compared to the rats in C group, which in A group and S1group were very significantly higher(P<0.01),but which in S2 group was very significantly lower (P<0.01); When compared to the rats in A group, which in S2 group was very significantly lower (P<0.01),but S1group were significantly higher(P<0.01/0.05); When compared to the rats in S1 group, which in S2 group was very significantly lower (P<0.01). Conclusions 1)Aerobic exercise can improve the antioxidant capacity of the brain, protect and repair the hippocampal neurons, change the morphological structure of hippocampal neurons, improve and maintain the brain's spatial learning and memory, and thus delay brain aging. 2)Aerobic exercise intervention can down-regulate the expression of PDE-4 gene, may directly activate the cAMP/PKA/CREB signal transduction pathway to promote the synthesis of some learning memory proteins, thereby improving the learning and memory ability of aging rats and delay brain aging. 3)The different periods of aerobic exercise on brain aging intervention were different. Aerobic exercise intervention in the aging process performed relatively well. Tip: sustained aerobic exercise need to better play its role.  

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