Taurolidine and povidone-iodine induce different types of cell death in malignant pleural mesothelioma

Lung Cancer ◽  
2007 ◽  
Vol 56 (3) ◽  
pp. 327-336 ◽  
Author(s):  
I. Opitz ◽  
B. Sigrist ◽  
S. Hillinger ◽  
D. Lardinois ◽  
R. Stahel ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Povidone Iodine ◽  
Pleural Mesothelioma ◽  
Different Types

scholarly journals Analysis of Expression of Programmed Cell Death 1 Ligand 1 (Pd-L1) in Malignant Pleural Mesothelioma (Mpm)

2014 ◽  
Vol 25 ◽  
pp. v1 ◽  
Author(s):  
S. Cedres ◽  
S. Ponce Aix ◽  
J. Zugazagoitia ◽  
A.B. Anguita ◽  
I. Sansano ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Programmed Cell Death 1

scholarly journals Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment

2017 ◽  
Vol 7 (3) ◽  
pp. e1398874 ◽  
Author(s):  
Chiara Riganti ◽  
Marcello Francesco Lingua ◽  
Iris Chiara Salaroglio ◽  
Chiara Falcomatà ◽  
Luisella Righi ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Therapeutic Potential ◽  
Pleural Mesothelioma ◽  
Immunogenic Cell Death

scholarly journals Analysis of Expression of Programmed Cell Death 1 Ligand 1 (PD-L1) in Malignant Pleural Mesothelioma (MPM)

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121071 ◽  
Author(s):  
Susana Cedrés ◽  
Santiago Ponce-Aix ◽  
Jon Zugazagoitia ◽  
Irene Sansano ◽  
Ana Enguita ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Programmed Cell Death 1

Analysis of expression of PTEN/PI3K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)

Lung Cancer ◽  
2016 ◽  
Vol 96 ◽  
pp. 1-6 ◽  
Author(s):  
S. Cedrés ◽  
S. Ponce-Aix ◽  
N. Pardo-Aranda ◽  
A. Navarro-Mendivil ◽  
A. Martinez-Marti ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Pi3k Pathway ◽  
Pleural Mesothelioma

scholarly journals Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells

2021 ◽  
Vol 8 ◽  
Author(s):  
Marika Rossini ◽  
Fernanda Martini ◽  
Elena Torreggiani ◽  
Francesca Fortini ◽  
Giorgio Aquila ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Notch Pathway ◽  
Cell Communication ◽  
Mesothelial Cells ◽  
Pleural Mesothelioma ◽  
Proliferative Effect ◽  
Pleural Mesothelial Cells ◽  
Different Types ◽  
Line Drug

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. Furthermore, metformin treatment hampered MPM cell proliferation and enhanced the apoptotic process, accompanied by decreased Notch1 activation.

scholarly journals PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Sayantani Sarkar Bhattacharya ◽  
Prabhu Thirusangu ◽  
Ling Jin ◽  
Debarshi Roy ◽  
Deokbeom Jung ◽  
...  
Keyword(s):  
Cell Death ◽  
Er Stress ◽  
Cancer Cells ◽  
Malignant Pleural Mesothelioma ◽  
Control Point ◽  
Nutrient Stress ◽  
Pleural Mesothelioma ◽  
Tem Analysis ◽  
Lactate Dehydrogenase Activity ◽  
Critical Control Point

Abstract The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a critical control point in the glycolytic pathway, decreases glucose uptake, ATP production, and lactate dehydrogenase activity and arrests malignant pleural mesothelioma (MPM) cells in the G0/G1 phase to induce cell death. To overcome this nutrient stress, inhibition of PFKFB3 activity led to an escalation in endoplasmic reticulum (ER) activity and aggravated ER stress mostly by upregulating BiP and GADD153 expression and activation of the endocytic Rac1-Rab5-Rab7 pathway resulting in a unique form of cell death called “methuosis” in both the sarcomatoid (H28) and epithelioid (EMMeso) cells. Transmission electron microscopy (TEM) analysis showed the formation of nascent macropinocytotic vesicles, which rapidly coalesced to form large vacuoles with compromised lysosomal function. Both immunofluorescence microscopy and co-immunoprecipitation analyses revealed that upon PFKFB3 inhibition, two crucial biomolecules of each pathway, Rac1 and Calnexin interact with each other. Finally, PFK158 alone and in combination with carboplatin-inhibited tumorigenesis of EMMeso xenografts in vivo. Since most cancer cells exhibit an increased glycolytic rate, these results provide evidence for PFK158, in combination with standard chemotherapy, may have a potential in the treatment of MPM.

scholarly journals Sorafenib inhibits ERK1/2 and MCL-1L phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma

2009 ◽  
Vol 8 (24) ◽  
pp. 2406-2416 ◽  
Author(s):  
Sharyn I. Katz ◽  
LanLan Zhou ◽  
Grace Chao ◽  
Charles D. Smith ◽  
Thomas Ferrara ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma
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