The role of hippocampal brain-derived neurotrophic factor in age-related differences in neuropathic pain behavior in rats

Life Sciences ◽  
2018 ◽  
Vol 197 ◽  
pp. 56-66 ◽  
Author(s):  
Hiroki Tateiwa ◽  
Takashi Kawano ◽  
Atsushi Nishigaki ◽  
Daiki Yamanaka ◽  
Bun Aoyama ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Pain Behavior ◽  
Age Related

The role of brain-derived neurotrophic factor in different animal models of neuropathic pain

2010 ◽  
Vol 14 (5) ◽  
pp. 473.e1-473.e9 ◽  
Author(s):  
Pascal Vanelderen ◽  
Tom Rouwette ◽  
Tamas Kozicz ◽  
Eric Roubos ◽  
Jan Van Zundert ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals The Role of Astrocytes in the Modulation ofK+-Cl−-Cotransporter-2 Function

2020 ◽  
Vol 21 (24) ◽  
pp. 9539
Author(s):  
Tomoya Kitayama
Keyword(s):  
Neuropathic Pain ◽  
Neurotrophic Factor ◽  
Sensory System ◽  
Brain Derived Neurotrophic Factor ◽  
Spontaneous Pain ◽  
Similar Reaction ◽  
Tactile Allodynia ◽  
Pain Models

Neuropathic pain is characterized by spontaneous pain, pain sensations, and tactile allodynia. The pain sensory system normally functions under a fine balance between excitation and inhibition. Neuropathic pain arises when this balance is lost for some reason. In past reports, various mechanisms of neuropathic pain development have been reported, one of which is the downregulation of K+-Cl−-cotransporter-2 (KCC2) expression. In fact, various neuropathic pain models indicate a decrease in KCC2 expression. This decrease in KCC2 expression is often due to a brain-derived neurotrophic factor that is released from microglia. However, a similar reaction has been reported in astrocytes, and it is unclear whether astrocytes or microglia are more important. This review discusses the hypothesis that astrocytes have a crucial influence on the alteration of KCC2 expression.

Role of brain-derived neurotrophic factor in the control of D3 receptor expression

1999 ◽  
Vol 9 ◽  
pp. 184-185 ◽  
Author(s):  
O. Guillin ◽  
L. Damier ◽  
N. Griffon ◽  
J. Diaz ◽  
P. Carroll ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Receptor Expression ◽  
D3 Receptor
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