scholarly journals Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat

Life Sciences ◽  
2012 ◽  
Vol 91 (1-2) ◽  
pp. 29-36 ◽  
Author(s):  
Fernanda Cechetti ◽  
Paulo Valdeci Worm ◽  
Gisele Lovatel ◽  
Felipe Moysés ◽  
Ionara Rodrigues Siqueira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Environmental Enrichment ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Behavioral Deficits ◽  
And Oxidative Stress

scholarly journals Electroacupuncture Attenuates Cognitive Impairment in Rat Model of Chronic Cerebral Hypoperfusion via miR-137/NOX4 Axis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xiaochen Bi ◽  
Yanfei Feng ◽  
Zemin Wu ◽  
Jianqiao Fang
Keyword(s):  
Oxidative Stress ◽  
Neuronal Apoptosis ◽  
Molecular Mechanisms ◽  
Artery Occlusion ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Protective Effects ◽  
And Oxidative Stress

Electroacupuncture has shown protective effects on cognitive decline. However, the underlying molecular mechanisms are not clear. The present study was conducted to determine whether the cognitive function was ameliorated in cerebral hypoperfusion rats following electroacupuncture and to investigate the role of miR-137/NOX4 axis. In this study, chronic cerebral hypoperfusion (CCH) model was established by bilateral common carotid artery occlusion. Electroacupuncture treatment attenuated brain injury in CCH model group via regulating miR-137/NOX4 axis. Furthermore, the data of neuronal apoptosis and oxidative stress were observed. Our findings indicated that (1) neuronal apoptosis and oxidative stress in CCH rats were significantly increased compared with control group; (2) the animal cognitive performance was evaluated using the Morris water maze (MWM). The results showed that electroacupuncture therapy ameliorated spatial learning and memory impairment in cerebral hypoperfusion rats; and (3) electroacupuncture therapy reduces neuronal apoptosis and oxidative stress by activating miR-137/NOX4 axis. These results suggest that electroacupuncture therapy for CCH may be mediated by miR-137/NOX4 axis. Electroacupuncture therapy may act as a potential therapeutic approach for chronic cerebral hypoperfusion.

Effect of endogenous sulfur dioxide on spatial learning and memory and hippocampal damages in the experimental model of chronic cerebral hypoperfusion

2020 ◽  
Vol 31 (3) ◽  
Author(s):  
Elaheh Ghasemi ◽  
Faezeh Afkhami Aghda ◽  
Mohammad Ebrahim Rezvani ◽  
Azadeh Shahrokhi Raeini ◽  
Zeynab Hafizibarjin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sulfur Dioxide ◽  
Tissue Damage ◽  
Neuronal Damage ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Vital Role ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Spatial Learning And Memory

AbstractBackgroundThe vascular changes due to cerebrovascular damage, especially on the capillaries, play a vital role in causing vascular dementia. Increasing oxidative stress can lead to tissue damage while reducing brain blood flow. The use of factors reducing the oxidative stress level can decrease the brain damages. Sulfur dioxide (SO2) is one of the most important air pollutants that lead to the development of severe brain damage in large quantities. However, studies have recently confirmed the protective effect of SO2 in cardiac ischemic injury, atherosclerosis and pulmonary infections.MethodsThe permanent bilateral common carotid artery occlusion (BCAO) method was used to induce chronic cerebral hypoperfusion (CCH). Two treatment groups of SO2 were studied. The animal cognitive performance was evaluated using the Morris water maze. Hippocampal tissue damage was examined after 2 months of BCAO. In the biochemical analysis, the activity of catalase and lipid peroxidation of the hippocampus was studied.ResultsNeuronal damage in hippocampus, as well as cognitive impairment in ischemia groups treated with SO2 showed a significant improvement. Catalase activity was also significantly increased in the hippocampus of treated groups.ConclusionsAccording to the results, SO2 is likely to be effective in reducing the CCH-caused damages by increasing the antioxidant capacity of the hippocampus.

scholarly journals Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Md. Mamun Al-Amin ◽  
Rabeya Sultana ◽  
Sharmin Sultana ◽  
Md. Mahbubur Rahman ◽  
Hasan Mahmud Reza
Keyword(s):  
Oxidative Stress ◽  
Adult Offspring ◽  
Behavioral Deficits ◽  
And Oxidative Stress

scholarly journals P3-339: Effects of environmental enrichment on a good experimental model of dementia: chronic cerebral hypoperfusion

2010 ◽  
Vol 6 ◽  
pp. S551-S551
Author(s):  
Fernanda Cechetti ◽  
Paulo Valdeci Worm ◽  
Carlos Alexandre Netto ◽  
Márcia L. Chaves
Keyword(s):  
Experimental Model ◽  
Environmental Enrichment ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion

Edaravone attenuates oxidative stress induced by chronic cerebral hypoperfusion injury: role of ERK/Nrf2/HO-1 signaling pathway

2017 ◽  
Vol 40 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Dandan Zhang ◽  
Yining Xiao ◽  
Peiyuan Lv ◽  
Zhenjie Teng ◽  
Yanhong Dong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion

Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease

Life Sciences ◽  
2018 ◽  
Vol 192 ◽  
pp. 238-245 ◽  
Author(s):  
Rajib Paul ◽  
Banashree Chetia Phukan ◽  
Arokiasamy Justin Thenmozhi ◽  
Thamilarasan Manivasagam ◽  
Pallab Bhattacharya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Behavioral Deficits ◽  
And Oxidative Stress
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