Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels

Life Sciences ◽  
2011 ◽  
Vol 88 (15-16) ◽  
pp. 653-657 ◽  
Author(s):  
Gláucia Maria Lopes Reis ◽  
Marina Abadia Ramos ◽  
Daniela da Fonseca Pacheco ◽  
André Klein ◽  
Andréa Castro Perez ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Cannabinoid Receptor ◽  
K Channels ◽  
Endogenous Cannabinoid

Pulmonary actions of anandamide, an endogenous cannabinoid receptor agonist, in guinea pigs

1998 ◽  
Vol 355 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Peter W. Stengel ◽  
Marian K. Rippy ◽  
Sandra L. Cockerham ◽  
William A. Devane ◽  
Steven A. Silbaugh
Keyword(s):  
Guinea Pigs ◽  
Receptor Agonist ◽  
Cannabinoid Receptor ◽  
Endogenous Cannabinoid

scholarly journals Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat

FEBS Letters ◽  
1996 ◽  
Vol 393 (2-3) ◽  
pp. 231-235 ◽  
Author(s):  
Christian C. Felder ◽  
Amie Nielsen ◽  
Eileen M. Briley ◽  
Miklós Palkovits ◽  
Joseph Priller ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Cannabinoid Receptor ◽  
Peripheral Tissues ◽  
Endogenous Cannabinoid

Molecular Modeling of an Orphan GPR18 Receptor

2019 ◽  
Vol 16 (10) ◽  
pp. 1167-1174 ◽  
Author(s):  
Kamil J. Kuder ◽  
Tadeusz Karcz ◽  
Maria Kaleta ◽  
Katarzyna Kiec-Kononowicz
Keyword(s):  
Cannabinoid Receptors ◽  
Cannabinoid Receptor ◽  
Glycine Receptor ◽  
Homology Model ◽  
Orphan Receptor ◽  
Receptor Ligands ◽  
Orphan Receptors ◽  
Inactive Form ◽  
Starting Point ◽  
Endogenous Cannabinoid

Background: : One of the best known to date GPCR class A (Rhodopsin) includes more than 100 orphan receptors for which the endogenous ligand is not known or is unclear. One of them is N-arachidonyl glycine receptor, named GPR18, a receptor that has been reported to be activated by Δ9-THC, endogenous cannabinoid receptors agonist anandamide and other cannabinoid receptor ligands suggesting it could be considered as third cannabinoid receptor. GPR18 activity, as well as its distribution might suggest usage of GPR18 ligands in treatment of endometriosis, cancer, and neurodegenerative disorders. Yet, so far only few GPR18 antagonists have been described, thus only ligand-based design approaches appear to be most useful to identify new ligands for this orphan receptor. Methods: : Main goal of this study, GPR18 inactive form homology model was built on the basis of the evolutionary closest homologous template: Human P2Y1 Receptor crystal structure. Results: : Obtained model was further evaluated and showed active/nonactive ligands differentiating properties with acceptable confidence. Moreover, it allowed for preliminary assessment of proteinligand interactions for a set of previously described ligands. Conclusion:: Thus collected data might serve as a starting point for a discovery of novel, active GPR18 blocking ligands.

scholarly journals Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide

Life Sciences ◽  
2009 ◽  
Vol 85 (9-10) ◽  
pp. 351-356 ◽  
Author(s):  
Gláucia Maria Lopes Reis ◽  
Daniela Pacheco ◽  
Andréa Castro Perez ◽  
André Klein ◽  
Marina Abadia Ramos ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Cannabinoid Receptor ◽  
Antinociceptive Action ◽  
Cgmp Pathway
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