Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats

Life Sciences ◽  
2006 ◽  
Vol 79 (23) ◽  
pp. 2209-2216 ◽  
Author(s):  
Asif R. Pathan ◽  
Bhoomi Viswanad ◽  
Swapnil K. Sonkusare ◽  
Poduri Ramarao
Keyword(s):  
Memory Impairment ◽  
Chronic Administration

scholarly journals Chronic Administration of Benzo(a)pyrene Induces Memory Impairment and Anxiety-Like Behavior and Increases of NR2B DNA Methylation

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149574 ◽  
Author(s):  
Wenping Zhang ◽  
Fengjie Tian ◽  
Jinping Zheng ◽  
Senlin Li ◽  
Mei Qiang
Keyword(s):  
Dna Methylation ◽  
Memory Impairment ◽  
Chronic Administration

Chronic administration of quetiapine attenuates the phencyclidine-induced recognition memory impairment and hippocampal oxidative stress in rats

Neuroreport ◽  
2018 ◽  
Vol 29 (13) ◽  
pp. 1099-1103 ◽  
Author(s):  
Jue He ◽  
Fan Liu ◽  
Qian Zu ◽  
Zhizhong Xu ◽  
Huifei Zheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Recognition Memory ◽  
Memory Impairment ◽  
Chronic Administration

Neoline Improves Memory Impairment and Reduces Amyloid-β Level and Tau Phosphorylation Through AMPK Activation in the Mouse Alzheimer’s Disease Model

2021 ◽  
pp. 1-10
Author(s):  
Quan Feng Liu ◽  
Suganya Kanmani ◽  
Jinhyuk Lee ◽  
Geun-Woo Kim ◽  
Songhee Jeon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Amyloid Β ◽  
Chronic Administration ◽  
Therapeutic Effects ◽  
Ampk Activation ◽  
The Brain ◽  
Ad Mouse Model

Background: Alzheimer’s disease (AD) is the most general, chronic, and progressive neurodegenerative senile disorder characterized clinically by progressive cognitive deterioration and memory impairment. Neoline is effective against neuropathic pain models, but the effects of neoline against AD-like phenotypes have not been investigated. Objective: We offer the investigation of the effects of neoline in AD. Methods: In this study, a Tg-APPswe/PS1dE9 AD mouse model was treated orally with neoline at a concentration of 0.5 mg/kg or 0.1 mg/kg starting at 7.5 months and administered for three months, and its anti-AD effects were evaluated. Results: Neoline improved memory and cognition impairments and reduced the number of amyloid-beta plaque and the amount of amyloid-β in the brain of AD mice. Furthermore, neoline reduced the anxiety behavior in the AD mouse model. The chronic administration of neoline also induced AMPK phosphorylation and decreased tau, amyloid-β, and BACE1 expression in the hippocampus. These findings indicate that chronic administration of neoline has therapeutic effects via AMPK activation, and BACE1 downregulation resulted in a decrease in the amyloid-β levels in the brain of Tg-APPswe/PS1dE9 AD mice. Conclusion: Our results suggest that neoline is a therapeutic agent for the cure of neurodegenerative diseases like AD.

scholarly journals DOCOSAHEXAENOIC ACID ADMINISTRATION AMELIORATES SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN MICE

2018 ◽  
Vol 11 (6) ◽  
pp. 349
Author(s):  
Kothari Saroj ◽  
Singhal Tulika
Keyword(s):  
Docosahexaenoic Acid ◽  
Memory Impairment ◽  
Escape Latency ◽  
Memory Function ◽  
Chronic Administration ◽  
Control Group ◽  
Gum Acacia ◽  
Impaired Memory ◽  
Nootropic Agent ◽  
Memory Enhancing

Objective: The main objective of this work was to study the memory-enhancing activity of docosahexaenoic acid (DHA) supplementation in normal memory function and scopolamine-induced impaired memory in mice.Methods: The gum acacia suspension of DHA was administered by gavage at the dose of 200 and 300 mg/kg in mice for 30 days to evaluate memory-enhancing potential on normal and scopolamine-induced impaired memory in albino mice. Escape latency in Morris water maze (MWM) and transfer latency (TL) in elevated plus maze (EPM) were recorded, respectively. Mice were given four trial sessions per day to locate the platform for 4 days in MWM model. Scopolamine 1 mg/kg was injected i.p. to produce memory impairment in mice.Result: DHA suspension at the dose of 300 mg/kg showed significant reduction of escape latency and TL as compared to control group, and the effect was comparable to that of standard nootropic agent piracetam at the dose of 100 mg/kg in normal and scopolamine-treated mice. However, DHA at the dose of 200 mg/kg showed significant memory-enhancing effect in only scopolamine-induced impaired memory model.Conclusion: The study revealed that the chronic administration of DHA exhibited significant memory-enhancing activity against both normal as well as scopolamine-treated impaired memory mice groups, however, this effect was more marked on scopolamine-induced memory impairment as compared to normal memory function.

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