Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells

2006 ◽  
Vol 147 (5) ◽  
pp. 234-241 ◽  
Author(s):  
Kim R. Bridle ◽  
Lin Li ◽  
Rosemary O’Neill ◽  
Robert S. Britton ◽  
Bruce R. Bacon
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Hepatic Stellate Cells ◽  
Intracellular Signaling ◽  
Stellate Cells ◽  
Platelet Derived Growth Factor ◽  
Insulin Like Growth Factor ◽  
Intracellular Signaling Pathways

scholarly journals Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

Endocrinology ◽  
1996 ◽  
Vol 137 (10) ◽  
pp. 4427-4434 ◽  
Author(s):  
T Sasaoka ◽  
M Ishiki ◽  
T Sawa ◽  
H Ishihara ◽  
Y Takata ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Insulin Like Growth Factor ◽  
Intracellular Signaling Pathways

scholarly journals The IGF-1 Signaling Pathway in Viral Infections

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1488
Author(s):  
Agata Józefiak ◽  
Magdalena Larska ◽  
Małgorzata Pomorska-Mól ◽  
Jakub J. Ruszkowski
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Intracellular Signaling ◽  
Viral Infections ◽  
Mapk Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Insulin Like Growth Factor ◽  
Intracellular Signaling Pathways

Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor (IGF-1R) belong to the insulin-like growth factor family, and IGF-1 activates intracellular signaling pathways by binding specifically to IGF-1R. The interaction between IGF-1 and IGF-1R transmits a signal through a number of intracellular substrates, including the insulin receptor substrate (IRS) and the Src homology collagen (Shc) proteins, which activate two major intracellular signaling pathways: the phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK) pathways, specifically the extracellular signal-regulated kinase (ERK) pathways. The PI3K/AKT kinase pathway regulates a variety of cellular processes, including cell proliferation and apoptosis. IGF1/IGF-1R signaling also promotes cell differentiation and proliferation via the Ras/MAPK pathway. Moreover, upon IGF-1R activation of the IRS and Shc adaptor proteins, Shc stimulates Raf through the GTPase Ras to activate the MAPKs ERK1 and ERK2, phosphorylate and several other proteins, and to stimulate cell proliferation. The IGF-1 signaling pathway is required for certain viral effects in oncogenic progression and may be induced as an effect of viral infection. The mechanisms of IGF signaling in animal viral infections need to be clarified, mainly because they are involved in multifactorial signaling pathways. The aim of this review is to summarize the current data obtained from virological studies and to increase our understanding of the complex role of the IGF-1 signaling axis in animal virus infections.

Sign in / Sign up

Export Citation Format

Share Document