scholarly journals Angiotensin II Type 1 receptor antibodies are associated with inflammatory cytokines and poor clinical outcomes in pediatric kidney transplantation

2018 ◽  
Vol 93 (1) ◽  
pp. 260-269 ◽  
Author(s):  
Meghan H. Pearl ◽  
Qiuheng Zhang ◽  
Miguel Fernando Palma Diaz ◽  
Jonathan Grotts ◽  
Maura Rossetti ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Angiotensin Ii ◽  
Clinical Outcomes ◽  
Inflammatory Cytokines ◽  
Pediatric Kidney Transplantation ◽  
Receptor Antibodies

scholarly journals Angiotensin II type 1 receptor antibodies in childhood kidney transplantation

2016 ◽  
Vol 20 (5) ◽  
pp. 627-632 ◽  
Author(s):  
Anna Bjerre ◽  
Trine Tangeraas ◽  
Harald Heidecke ◽  
Duska Dragun ◽  
Ralf Dechend ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Angiotensin Ii ◽  
Receptor Antibodies

scholarly journals Angiotensin II type 1 receptor antibodies in kidney transplantation: An evidence-based comprehensive review

2020 ◽  
Vol 34 (4) ◽  
pp. 100573
Author(s):  
Bogdan Marian Sorohan ◽  
Gener Ismail ◽  
Nicolae Leca ◽  
Dorina Tacu ◽  
Bogdan Obrișcă ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Angiotensin Ii ◽  
Evidence Based ◽  
Comprehensive Review ◽  
Receptor Antibodies

scholarly journals MO931PRETRANSPLANT ANGIOTENSIN II TYPE 1 RECEPTOR ANTIBODIES INFLUENCE GRAFT FUNCTION BUT NOT GRAFT SURVIVAL AT 1 YEAR AFTER KIDNEY TRANSPLANTATION IN A LOW IMMUNOLOGICAL RISK COHORT

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Bogdan Marian Sorohan ◽  
Andreea Ioana Berechet ◽  
Bogdan Obrisca ◽  
Ileana Constantinescu ◽  
Ionut Maruntelu ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Kidney Transplantation ◽  
Angiotensin Ii ◽  
Graft Rejection ◽  
Graft Failure ◽  
Cox Regression ◽  
Graft Function ◽  
Receptor Antibodies ◽  
Independent Determinant

Abstract Background and Aims Angiotensin II type 1 receptor antibodies (AT1R-Ab) are associated with graft rejection and poor graft outcomes in kidney transplantation (KT). It has been shown that AT1R-Ab have a negative impact on both short-term and long-term graft function, even in the absence of rejection, but this has not been confirmed by other studies. Our aim was to assess the frequency of pretransplant AT1R-Ab and to determine their influence on graft function and survival at 1 year after KT. Method We performed a prospective, observational cohort study in 67 adult KT recipients, transplanted between October 2018 and October 2019. Clinical, biological and immunological data of the recipients, age, gender and type of donor, transplant and immunosuppression parameters were collected at the moment of transplantation. A cut-off > 10 U/mL was used for AT1R-Ab detection. Results Among the 67 recipients mean age was 41.3 ± 10.3 years, male gender was predominant (59.7%) and the main known cause of end-stage renal disease was glomerular disease. Six patients out of 67 (9%) had a previous kidney transplant. The donor mean age was 50 ± 15.5 years and 65.7% of patients received the kidney graft from a cadaveric donor. Pretransplant AT1R-Ab were detected in 7 out of 67 patients (10.4%) and none of the patients had specific antibodies against human leucocyte antigen. After 1 year of follow-up, median estimated glomerular filtration rate (eGFR) of the recipients was 54 ml/min/1.73 m2 (40.6 – 65.9), 10.4% of patients developed delayed graft function, 7.5% had graft failure and no cases of biopsy proven graft rejection or death was reported. Patients with pretransplant AT1R-Ab had a significant reduced graft function at 1 year after KT compared to those without antibodies [35 (29.8- 55.2) vs 56.1 (41.3 – 66.5) ml/min, p=0.02]. After multivariate linear regression analysis, pretransplant AT1R-Ab were an independent determinant of eGFR at 1 year after KT (β: -14.066; 95% CI: -27.44 - -0.68; p=0.04). Cox regression analysis was used to assess the association of AT1R-Ab along with other clinical, biological and immunological parameters with graft failure. Neither the univariate (HR= 2.07, 95% CI: 0.23-18.52, p=0.51) nor the multivariate (HR= 1.36, 95% CI: 0.10-14.09, p=0.80) Cox regression models showed that pretransplant AT1R-Ab were an independent predictor for graft loss. Conclusion We showed that pretransplant AT1R-Ab are an independent determinant of graft function but do not influence the graft survival at 1 year after transplantation in a prospective low immunological risk cohort of kidney transplant recipients.

Association of Anti-Human Leukocyte Antigen and Anti-Angiotensin II Type 1 Receptor Antibodies With Liver Allograft Fibrosis After Immunosuppression Withdrawal

2014 ◽  
Vol 98 (10) ◽  
pp. 1105-1111 ◽  
Author(s):  
Hidenori Ohe ◽  
Yoichiro Uchida ◽  
Atsushi Yoshizawa ◽  
Hirofumi Hirao ◽  
Michiko Taniguchi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Liver Allograft ◽  
Leukocyte Antigen ◽  
Receptor Antibodies
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