scholarly journals Natural regulatory T cells from patients with end-stage renal disease can be used for large-scale generation of highly suppressive alloantigen-specific Tregs

2017 ◽  
Vol 91 (5) ◽  
pp. 1203-1213 ◽  
Author(s):  
Nicolle H.R. Litjens ◽  
Karin Boer ◽  
Joke M. Zuijderwijk ◽  
Mariska Klepper ◽  
Annemiek M.A. Peeters ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Large Scale ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Influence of hemodialysis on circulating CD4lowCD25high regulatory T cells in end-stage renal disease patients

2013 ◽  
Vol 63 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Katarzyna A. Lisowska ◽  
Alicja Dębska-Ślizień ◽  
Aleksandra Jasiulewicz ◽  
Ewa Bryl ◽  
Jacek M. Witkowski
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals CD28null and Regulatory T Cells Are Substantially Disrupted in Patients with End-Stage Renal Disease Due to Diabetes Mellitus

2021 ◽  
Vol 22 (6) ◽  
pp. 2975
Author(s):  
Erasmia Sampani ◽  
Dimitra-Vasilia Daikidou ◽  
George Lioulios ◽  
Aliki Xochelli ◽  
Zoi Mitsoglou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cell Immunity ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background: End-stage renal disease (ESRD) is associated with alterations in T-cell immunity, including increased CD28null and reduced regulatory T cells (Tregs). However, whether immune disturbances are due to ESRD or primary disease is not yet clear. As diabetes mellitus is the leading cause of ESRD, we evaluated its impact on the immune profile of ESRD patients. Methods: CD28null, Tregs, and natural killer cells were initially analyzed by flow cytometry in 30 predialysis ESRD patients due to diabetes (DM), 30 non-DM (NDM), and 25 healthy controls. Measurements were repeated after 6 months on hemodialysis (HD) or peritoneal dialysis (CAPD). Results: The percentage of CD4 + CD28null cells, CD8 + CD28null cells, and Tregs showed significant differences in DM, NDM, and controls; mean rank 33.71 vs. 25.68 vs. 18.88, p = 0.006, 37.79 vs. 28.82 vs. 17.08, p = 0.008, and 20.79 vs. 26.12 vs. 41.33, p = 0.001, respectively. DM vs. NDM had increased CD4 + CD28null and CD8 + CD28null cells, 11.5% (1.5%–24%) vs. 4.1% (0–42.3%), p = 0.02 and 61.3% (24%–76%) vs. 43% (5.7%–85%), p = 0.04, respectively. After 6 months on HD but not CAPD, DM showed a significant further increase in CD4 + CD28null cells, from 30 (14–100) to 52.7 (15–203), p = 0.02; and CD8 + CD28null cells, from 137 (56–275) to 266 (103–456), p = 0.01. Conclusions: Diabetes mellitus affects T-cell subtypes even at predialysis stage, though changes become more prominent after commencement on HD.

Characterization of Rabbit Antithymocyte Globulins-Induced CD25+ Regulatory T Cells From Cells of Patients With End-Stage Renal Disease

2010 ◽  
Vol 89 (6) ◽  
pp. 655-666 ◽  
Author(s):  
Varsha D. K. D. Sewgobind ◽  
Luc J. W. van der Laan ◽  
Marcia M. L. Kho ◽  
Rens Kraaijeveld ◽  
Sander S. Korevaar ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease

2020 ◽  
Vol 33 (4) ◽  
pp. 817-827
Author(s):  
Fabian Meyer ◽  
Felix S. Seibert ◽  
Mikalai Nienen ◽  
Marius Welzel ◽  
Daniela Beisser ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

End stage renal disease has an early and continuous detrimental effect on regulatory T cells

Nephrology ◽  
2021 ◽  
Author(s):  
Erasmia Sampani ◽  
Lampis Vagiotas ◽  
Dimitra‐Vasilia Daikidou ◽  
Vasiliki Nikolaidou ◽  
Aliki Xochelli ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Detrimental Effect ◽  
Stage Renal Disease ◽  
End Stage

Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy

2018 ◽  
Vol 93 (6) ◽  
pp. 1452-1464 ◽  
Author(s):  
Sybille Landwehr-Kenzel ◽  
Anne Zobel ◽  
Henrike Hoffmann ◽  
Niels Landwehr ◽  
Michael Schmueck-Henneresse ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplantation ◽  
Cell Therapy ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Ex Vivo ◽  
Autologous Cell ◽  
Autologous Cell Therapy ◽  
Stage Renal Disease ◽  
End Stage

Erythrocyte Adhesion in Hemodialysis Patients – A Novel Potential Contributor to Inflammation in End-Stage Renal Disease.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2092-2092
Author(s):  
Vimal K. Derebail ◽  
Adam McDonald ◽  
Julia Brittain
Keyword(s):  
T Cells ◽  
Endothelial Cells ◽  
Renal Disease ◽  
Sickle Cell ◽  
End Stage Renal Disease ◽  
Sickle Cell Trait ◽  
Hemodialysis Patients ◽  
Healthy Control ◽  
Stage Renal Disease ◽  
End Stage

Abstract Abstract 2092 Background: Widespread adhesion of erythrocytes in the vasculature would be incompatible with life. However, in illnesses such as sickle cell disease, malaria and diabetes, adhesive RBCs have been documented and are likely contributors to disease severity, inflammation and coagulation activation. End-stage renal disease is characterized by profound, global inflammation and relative thrombophilia. While we, and others, have reported the extensive exposure of RBC phosphatidylserine in patients on hemodialysis, the role of RBC adhesion in inflammation has never been examined in this condition. We performed an analysis of RBCs from hemodialysis patients to characterize their ability to adhere to other cells, elucidate the potential mechanisms of adhesion, and to relate RBC adhesion to the inflammatory state of hemodialysis. Methods: This study was conducted in a cohort of 20 African American patients receiving in-center hemodialysis at 2 separate dialysis clinics as part of a study of sickle cell trait in hemodialysis. There were 9 of 20 patients with documented sickle cell trait. Blood samples were drawn immediately pre-dialysis and prior to administration of heparin. Plasma samples were processed to minimize platelet activation, aliquoted, and frozen for batch analysis. Plasma factors (RANTES, CRP & CD40L) were analyzed via ELISA. Adhesion events in whole blood were detected via two color flow cytometry. Cause of renal failure, mode of venous access and relevant clinical data were obtained from patient charts. All adhesion assays with washed blood cells were conducted under static conditions using microvascular endothelial cells. All studies were compared to those results of healthy control patients (n =11). Spearman's regression analysis was performed to analyze the correlation between continuous variables. Mann-Whitney U and Kruskal Wallis tests were used to compare continuous variables between groups. A p<0.05 was considered significant. Results: We found that RBCs from patients on hemodialysis were significantly more adhesive than those from healthy controls. In whole blood, we detected marked RBC adhesion to T-cells (median % of T-cells bound to RBCs: 67.9 [hemodialysis] vs. 10.55 [healthy control]) and platelets (median % of platelets bound to RBCs: 33.0 vs. 1.1%). We also noted significant RBC adhesion to neutrophils (median % of neutrophils bound to RBCs: 11.0% vs. 0.1%). Incubation of healthy RBCs with plasma from hemodialysis patients, but not healthy control plasma, was sufficient to induce RBC adhesion to cultured endothelial cells (median RBCs/mm2: 8.0 vs. 0.5) and to T-cells (median % T-cells bound to RBCs: 30.0 vs. 5.0). Plasma from hemodialysis patients also induced phosphatidylserine exposure on healthy RBCs. Phosphatidylserine exposure on the RBC appeared to mediate RBC adhesion to endothelial cells as annexin V significantly reduced RBC adherence (8.0 vs 3.8 RBC/mm2). The extent to which RBCs in hemodialysis patients adhered to T-cells directly correlated with both plasma RANTES (rspearman = 0.65, 95% CI: 0.247–0.864) and CD40L levels (rspearman= 0.60, 95% CI: 0.1645 – 0.847), but not plasma CRP levels. There was also no significant difference in adhesion of RBCs due to cause of renal failure (diabetes, hypertension, or glomerulonephritis) or presence of sickle cell trait. Conclusions: We describe for the first time a novel adhesion of RBCs in patients receiving hemodialysis and how this adhesion may relate to inflammation in these patients. Our findings also suggest that factors in uremic plasma are sufficient to induce phosphatidylserine exposure on RBCs. This exposure, in addition to providing a site for thrombin generation, also serves as an adhesive moiety on RBCs for endothelial cells. These data may describe an unrecognized etiology of inflammation in hemodialysis and end-stage renal disease. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Diabetic nephropathy as a cause of end-stage renal disease in Egypt: a six-year study

2004 ◽  
Vol 10 (4-5) ◽  
pp. 620-626 ◽  
Author(s):  
A. Afifi ◽  
M. El Setouhy ◽  
M. El Sharkawy ◽  
M. Ali ◽  
H. Ahmed ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Large Scale ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

The prevalence of diabetic nephropathy as a cause of end-stage renal disease [ESRD] in Egypt has been examined in small cross-sectional studies, with conflicting results. The need for a large-scale study prompted us to perform this 6-year multiple cross-sectional study. A sample of ESRD patients enrolled in the Egyptian renal data system was evaluated during the period 1996-2001 for the prevalence of diabetic nephropathy. Prevalence gradually increased from 8.9% in 1996, to 14.5% in 2001. The mean age of patients with diabetic nephropathy was significantly higher than that of patients with ESRD from other causes. Mortality was also significantly higher in diabetic patients with ESRD

scholarly journals Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan: data from nationwide large-scale registry 2014–2018

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Abduzhappar Gaipov ◽  
Alpamys Issanov ◽  
Kainar Kadyrzhanuly ◽  
Dinara Galiyeva ◽  
Marina Khvan ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Renal Disease ◽  
Survival Probability ◽  
End Stage Renal Disease ◽  
Older Patients ◽  
Large Scale ◽  
Dialysis Patients ◽  
Risk Of Death ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, via aggregation and utilization of large-scale administrative healthcare data. Methods The registry data of 8898 patients receiving dialysis therapy between 2014 and 2018 years were extracted from the Unified National Electronic Health System (UNEHS) and linked with the national population registry of Kazakhstan. We provide descriptive statistics of demographic, comorbidity and dialysis-related characteristics. Results Among all patients undergoing maintenance dialysis for end-stage renal disease (ESRD), there were 3941 (44%) females and 4957 (56%) males. 98.7% of patients received hemodialysis and 1.3% peritoneal dialysis. The majority of the patients (63%) were ethnic Kazakhs, 18% were Russians and 19% were of other ethnicities. The prevalence and incidence rate in 2014 were 135.2 and 68.9 per million population (PMP), respectively, which were different in 2018 [350.2 and 94.9 PMP, respectively]. Overall mortality rate among dialysis patients reduced from 1667/1000 patient-years [95%Confidence Interval (CI): 1473–1886] (PY) in 2014 to 710/1000PY [95%CI: 658–767] in 2018. We observed 13% lower crude survival probability in females compared to males and in older patients compared to younger ones. Russian ethnicity had 58% higher risk of death, while other ethnicities had 34% higher risk of death compared to in those of Kazakh ethnicity. Conclusion We describe for the first time in Kazakhstan an increase in the prevalence and incidence of ESRD on dialysis, while mortality rate decreased over time, during 2014–2018. We observed statistically significant lower survival probability in female dialysis patients compared to males, in older patients compared to younger ones, and in patients of Russian ethnicity compared to Kazakh.

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