scholarly journals Improved kinetic model for the transcutaneous measurement of glomerular filtration rate in experimental animals

2016 ◽  
Vol 90 (6) ◽  
pp. 1377-1385 ◽  
Author(s):  
Jochen Friedemann ◽  
Ralf Heinrich ◽  
Yury Shulhevich ◽  
Matthias Raedle ◽  
Lena William-Olsson ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Kinetic Model ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Experimental Animals ◽  
Transcutaneous Measurement

scholarly journals Validation of non‐invasive transcutaneous measurement for glomerular filtration rate in lean and obese C57BL / 6J mice

Nephrology ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 575-581
Author(s):  
Thomas P. Mullins ◽  
Wei Sheng Tan ◽  
David A. Carter ◽  
Linda A. Gallo
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Non Invasive ◽  
Transcutaneous Measurement

scholarly journals Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats

2009 ◽  
Vol 24 (10) ◽  
pp. 2997-3001 ◽  
Author(s):  
Daniel Schock-Kusch ◽  
Maliha Sadick ◽  
Nadja Henninger ◽  
Bettina Kraenzlin ◽  
Guenter Claus ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Transcutaneous Measurement

A Novel Analysis Technique for Transcutaneous Measurement of Glomerular Filtration Rate With Ultralow Dose Marker Concentrations

2016 ◽  
Vol 63 (8) ◽  
pp. 1742-1750 ◽  
Author(s):  
Anatoli Shmarlouski ◽  
Daniel Schock-Kusch ◽  
Yury Shulhevich ◽  
Volker Buschmann ◽  
Tino Rohlicke ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Ultralow Dose ◽  
Analysis Technique ◽  
Transcutaneous Measurement

Pseudouridine is unsuitable as an endogenous renal clearance marker.

1988 ◽  
Vol 34 (6) ◽  
pp. 1011-1017 ◽  
Author(s):  
J T Bernert ◽  
C J Bell ◽  
J Guntupalli ◽  
W H Hannon
Keyword(s):  
High Performance Liquid Chromatography ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
High Performance ◽  
Filtration Rate ◽  
Healthy Men ◽  
Experimental Animals ◽  
Potential Use ◽  
Urine Specimens ◽  
Serum And Urine

Abstract We assessed the clearance of endogenous pseudouridine in humans to evaluate the potential use of this modified nucleoside as a marker of glomerular filtration rate. Pseudouridine concentrations in serum ultrafiltrates and in the corresponding 24-h urine specimens from 19 healthy men were determined by high-performance liquid chromatography. Mean (and SD) pseudouridine concentrations in serum and urine from this group averaged 2.77 (0.34) mumol/L and 203.2 (64.8) mumol/L, respectively. The calculated clearances of the nucleoside [87.3 (24.9) mL/min, n = 19], however, averaged approximately one-third lower than the corresponding creatinine clearances in the same individuals [131.8 (28.4) mL/min]. Measurement of simultaneous clearances of [3H]pseudouridine and [14C]inulin in rats also yielded a lower pseudouridine clearance, 0.78 relative to inulin. Our results are thus consistent with a partial net reabsorption of pseudouridine in both experimental animals and in humans, indicating that this compound would not be a suitable endogenous marker for routine estimation of the glomerular filtration rate.

scholarly journals Transcutaneous measurement of glomerular filtration rate in small rodents: Through the skin for the win?

Nephrology ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 117-123 ◽  
Author(s):  
Stacey J Ellery ◽  
Xiaochu Cai ◽  
David D Walker ◽  
Hayley Dickinson ◽  
Michelle M Kett
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Small Rodents ◽  
Transcutaneous Measurement

Transcutaneous Measurement of Glomerular Filtration Rate in Rodents

2019 ◽  
pp. 129-137
Author(s):  
Cristina Daniele ◽  
Daniela Nardozi ◽  
Angelo Torelli ◽  
Arif ul Maula Khan ◽  
Norbert Gretz
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Transcutaneous Measurement

Clinical Renal Function Testing by External Double Isotope Monitoring Technique

1971 ◽  
Vol 10 (01) ◽  
pp. 16-24
Author(s):  
J. Fog Pedersen ◽  
M. Fog Pedersen ◽  
Paul Madsen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Correlation Coefficients ◽  
Feedback System ◽  
Effective Renal Plasma Flow ◽  
Advantages And Disadvantages

SummaryAn accurate catheter-free technique for clinical determination simultaneouslyof glomerular filtration rate and effective renal plasma flow by means of radioisotopes has been developed. The renal function is estimated by the amount of radioisotopes necessary to maintain a constant concentration in the patient’s blood. The infusion pumps are steered by a feedback system, the pumps being automatically turned on when the radiation measured over the patient’s head falls below a certain preset level and turned off when this level is again readied. 131I-iodopyracet was used for the estimation of effective renal plasma flow and125I-iothalamate estimation of the glomerular filtration rate. These clearances were compared to the conventional bladder clearances and good correlation was found between these two clearance methods (correlation coefficients 0.97 and.90 respectively). The advantages and disadvantages of this new clearance technique are discussed.

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