A Randomized, Double-Blind, Placebo-Controlled, Clinical Study on the Efficacy and Safety of Calcium Dobesilate in the Treatment of Chronic Venous Insufficiency

2017 ◽  
Vol 5 (1) ◽  
pp. 143
Author(s):  
E. Rabel ◽  
S. Ballarini ◽  
L. Lehr
Keyword(s):  
Clinical Study ◽  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Efficacy And Safety ◽  
Calcium Dobesilate ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Controlled Clinical Study

Effectiveness and safety of calcium dobesilate in treating chronic venous insufficiency: randomized, double-blind, placebo-controlled trial

2004 ◽  
Vol 19 (3) ◽  
pp. 123-130 ◽  
Author(s):  
K-H Labs ◽  
S Degischer ◽  
G Gamba ◽  
K A Jaeger
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Controlled Trial ◽  
Primary Outcome Measure ◽  
Calcium Dobesilate ◽  
Double Blind ◽  
Volume Calculation ◽  
Double Blind Placebo ◽  
Cone Model ◽  
The Difference

Objective: To determine whether calcium dobesilate is effective in reducing chronic venous insufficiency-related peripheral oedema. Methods: Randomized, double-blind, placebo-controlled, multicentre, parallel-group study in 253 consecutive outpatients with chronic venous insufficiency (CEAP C3-C4). The patients were treated for four weeks with either calcium dobesilate (CaD) 500 mg three times a day or matching placebo. The primary outcome measure was the reduction in lower leg volume. The leg volume calculation was based on a truncated cone model Results: Active drug treatment resulted in a median reduction of the leg volume of 25.5 ± 33.6 ml/l tissue. The difference in the median change of the leg volume between the treatment groups at week 4 was -12.2 ml/l tissue (95 % CI -21.6 to -2.8; P =0.01). In contrast with the placebo, the effects of CaD were independent of the duration of CVI and most pronounced in more severely diseased patients. Safety variables did not differ significantly between groups. Conclusions: Calcium dobesilate is an effective and well tolerated treatment for chronic venous insufficiency.

Sign in / Sign up

Export Citation Format

Share Document