scholarly journals LEV 11. Effects of Two Nursing Care Plans of Hydration Therapy for the Renal Function of Patients With Deep Venous Thrombosis in the Lower Limbs After Receiving AngioJet Thrombectomy Surgery

2019 ◽  
Vol 70 (5) ◽  
pp. e173
Author(s):  
Yanjie Wang ◽  
Yong Cheng
Keyword(s):  
Renal Function ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Nursing Care ◽  
Lower Limbs ◽  
Care Plans ◽  
Hydration Therapy

scholarly journals Home versus in-hospital treatment of outpatients with acute deep venous thrombosis of the lower limbs

2014 ◽  
Vol 59 (5) ◽  
pp. 1362-1367.e1 ◽  
Author(s):  
Francisco Lozano ◽  
Javier Trujillo-Santos ◽  
Manuel Barrón ◽  
Pedro Gallego ◽  
Dimitrios Babalis ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Lower Limbs ◽  
Hospital Treatment

Deep venous thrombosis of lower limbs in adolescents: a study in a tertiary hospital

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Catarina Faria ◽  
Henedina Antunes ◽  
Teresa Pontes ◽  
Ana Antunes ◽  
Sofia Martins ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Oral Contraceptive ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Positive Family History ◽  
Oral Contraceptive Pill ◽  
Tertiary Hospital ◽  
Lower Limbs ◽  
Factor V Leiden Mutation

AbstractBackgroundVenous thromboembolism (VTE) – which includes deep venous thrombosis (DVT) and pulmonary embolism (PE) – has been increasingly recognized in the pediatric population. The estimated incidence is 0.07–0.14 cases per 10,000 children. Most cases are associated with two or more risk factors. Medium and long-term complications include recurrence and post-thrombotic syndrome (PTS).ObjectiveTo characterize the adolescent population with the diagnosis of DVT of lower limbs in a tertiary hospital, regarding its clinical presentation, associated risk factors, treatment and outcome.MethodsRetrospective analysis of adolescents with the diagnosis of DVT of lower limbs in our hospital for a period of 7 years.ResultsEight patients were identified; seven were females; median age was 15 years. The main symptoms were local pain and edema. Left lower limb was affected in six patients. PE occurred in two cases. Positive family history of venous thromboembolism was found in five patients. Seven patients had at least two identifiable risk factors. Combined oral contraceptive pill use was the most common (seven patients). Factor V Leiden mutation was found in three patients and protein C deficiency in one. Iliac vein compression syndrome was diagnosed in one patient. The median time for discharge was 8 days. Election treatment was enoxaparin followed by warfarin, for a median period of 10.9 months. Three patients developed PTS.ConclusionsAlthough uncommon, VTE is an emerging reality in adolescents, particularly in females using oral contraceptive pills. Appropriated prevention strategies and treatment are required as most orientations are extrapolated from adults.

Metabolic and Inflamatory Proteins Differently Expressed in Platelets From Deep Venous Thrombosis Patients

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 5256-5256
Author(s):  
Mariane Cristina Flores Nascimento ◽  
Karina Kleinfelder-Fontanesi ◽  
Fernanda Loureiro de Andrade Orsi ◽  
Steven H Seeholzer ◽  
Harry Ischiropoulos ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Conflicts Of Interest ◽  
Lower Limbs ◽  
Apolipoprotein A1 ◽  
Blood Samples ◽  
Orbitrap Mass Spectrometer ◽  
Inflammatory Processes ◽  
History Of

Abstract Abstract 5256 BACKGROUND: Deep venous thrombosis (DVT) is multi-causal disease associated to a high morbi-mortality due to complications as pulmonary embolism and post-flebitic syndrome. The incidence is about 20 to 30%, and 25% of the patients will present recurrence in 5 years. The identification of new risk factors is important in clinical practice to prevent new thrombotic events. The role of the platelets on DVT is still not well defined. AIM: The objective of this study was to analyze the hole proteins profile of platelets obtained from DVT patients and compare to the same matherial derived from healthy controls. PATIENTS: peripheral blood samples were collected from 3 spontaneous DVT patients and from 1 sibling and 1 neighbor for each patient in order to minimize the genetic and environmental interferences. These patients presented spontaneous and recurrent episodes of lower limbs proximal DVT and all of them mentioned a familiar history of coagulation disorders. METHODS: the platelets were washed, lysed, and the proteins were alkylated, reduced, precipitated with acetone and hydrolyzed by trypsin. 100mg of peptides were then separated by hydrophobicity using HPLC, and 8 fractions were obtained and directed to the LTQ-Orbitrap mass spectrometer. The proteins search was performed by Sorcerer-SEQUEST. RESULTS: We identified 5 proteins that were present on patients and absent in all the controls: Apolipoprotein A1 Binding-Protein, Coatomer (z1 sub-unit), Estradiol 11–17-b Dehydrogenase, Leucotriene A-4 Hydrolase and Sorbitol Dehydrogenase. Western-Blotting was performed with specific antibodies and validated the results. CONCLUSIONS: with this study it was possible to identify proteins up to date non-related to the physiopathology of DVT, that could be involved with metabolic and inflammatory processes. Disclosures: No relevant conflicts of interest to declare.

Influence of Variability of Interpretation of Contrast Venography for Screening of Postoperative Deep Venous Thrombosis on the Results of a Thromboprophylactic Study

1993 ◽  
Vol 70 (04) ◽  
pp. 573-575 ◽  
Author(s):  
Frédéric Couson ◽  
Colette Bounameaux ◽  
Cominique Didier ◽  
Daniel Geiser ◽  
Michael F Meyerovitz ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Low Molecular Weight Heparin ◽  
Interobserver Variability ◽  
Initial Evaluation ◽  
Lower Limbs ◽  
Low Molecular Weight ◽  
True Coefficient ◽  
Heparin Fractions ◽  
Postoperative Deep Venous Thrombosis

SummaryTo assess interobserver variability of venography for screening for postoperative deep venous thrombosis (DVT), we used 185 bilateral ascending contrast venograms (366 lower limbs) which were performed using the long-leg film technique, in the frame of a trial of the efficacy of two low-molecular-weight-heparin fractions (initial evaluation). These venograms were submitted in a multicenter setting to three further readers who performed a serial scoring as DVT, no DVT or non-evaluable. DVTs were diagnosed in 78, 55 and 59/366 limbs (initial evaluation: 58). The proximal locations of DVTs were 16, 9 and 16 (initial evaluation: 15) and the non evaluable limbs 3, 5 and 18 (initial evaluation: 0). Apparent pairwise agreement between the three readers ranged from 87 to 90% (true coefficient of agreement Kappa 0.63-0.70). It ranged from 89 to 93% (Kappa 0.63-0.74) for the comparison between the readers and the initial evaluation. This considerable degree of disagreement among experienced readers should be taken into account in calculating sample sizes in prospective thromboprophylactic studies. Indeed, one of the two prophylactic regimens proved to be significantly (p = 0.012, p = 0.031, p = 0.049) or non-significantly (p = 0.073) superior to the other one depending upon the reading of venograms.

Double-Blind, Randomized Comparison of Systemic Continuous Infusion of 0.25 Versus 0.50 mg/kg/24 h of Alteplase over 3 to 7 Days for Treatment of Deep Venous Thrombosis in Heparinized Patients: Results of the European Thrombolysis with rt-PA in Venous Thrombosis (ETTT) Trial

1992 ◽  
Vol 67 (03) ◽  
pp. 306-309 ◽  
Author(s):  
H Bounameaux ◽  
J D Banga ◽  
E Bluhmki ◽  
S Coccheri ◽  
J N Fiessinger ◽  
...  
Keyword(s):  
Treatment Group ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Continuous Infusion ◽  
Dosage Regimen ◽  
Lower Limbs ◽  
Double Blind ◽  
Vein Thrombosis ◽  
Group I ◽  
Group Ii

SummaryThirty-two patients with acute, proximal-vein thrombosis were treated with heparin and alteplase (0.25 versus 0.5 mg/kg/24 h during 3-7 days) in a randomized, double-blind, multicenter, European (ETTT) trial. The treatment resulted in a decrease of the venographic Marder’s score from 18 (6-25) to 13 (2-24) units (median, range) in Group I (0.25 mg/kg/24 h, n = 15, median decrease 3.0, p = 0.32) and from 17.5 (3-33) to 15.5 (0-27) in Group II (0.5 mg/kg/24 h, n = 16, median decrease 4.0, p = 0.23). Comparison of the sequential venograms could be performed in 14 cases of Group I and in 15 cases in Group II. A minority of patients showed substantial partial recanalization of the initially obstructed veins on the control venogram (one in each treatment group) and most of the control venograms showedThus, the results of the ETTT trial show that the used low dosages of alteplase administered intravenously over 3-7 days in heparinized patients cannot be recommended as a treatment for patients with deep venous thrombosis of lower limbs and/or pelvis. Further studies are needed to define a more suitable dosage regimen of alteplase in this indication.

Venographic Studies on the Role of Valve Pockets in Thrombogenesis with Clinical Comments

1975 ◽  
Author(s):  
L. Diener ◽  
J.L.E. Ericsson ◽  
F. Lund
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Contrast Medium ◽  
Lower Limbs ◽  
Fatal Pulmonary Embolism ◽  
Early Type ◽  
Clinical Series ◽  
Good Agreement

In postmortem exploration of the veins of the lower limbs for studies of the frequency and significance of thromboembolism intraosseous venography with injection of contrast medium into the calcaneus was performed followed by complete dissection of the leg veins. A good agreement was found between venographic results and dissection findings. Out of the 596 legs examined, deep venous thrombosis was found in 229 (38%). In 32 of the lower limbs (5.4%) a definite localization and adherence of thrombi to valve pockets was noted. Altogether, 37 such thrombi were encountered. In addition 9 small thrombi of early type were found floating freely in the venous lumen just above a pocket. Microscopically the thrombi showed the greatest degree of organization at the bottom of the valve pocket speaking for this localization as the origin of formation. This is in accordance with the fact that stasis of blood would be most pronounced at the bottom of valve pockets as shown by retention of contrast medium in pockets in clinical venography. In a clinical series of venographies performed after hip surgery several thrombi located to valve pockets were found. Some of these thrombi had proximally free floating tails forming a potential menace of fatal pulmonary embolism.

Rivaroxaban versus Warfarin in the Management of Deep Venous Thrombosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mahmoud Shawky El-metieni ◽  
Tamer Mohamed Fekry ◽  
Mohammed Ahmed Hassan Rady ◽  
Ahmed Magdy Farrag ◽  
Ahmed Mohamed Ismail
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Randomized Study ◽  
Duplex Ultrasound ◽  
Lower Limbs ◽  
P Value ◽  
Vein Thrombosis ◽  
Warfarin Group ◽  
Blood Clots ◽  
Study Population

Abstract Background Deep venous thrombosis (DVT) refers to the formation of one or more blood clots in one of the body’s large veins, most commonly in the lower limbs. The clot can cause partial or complete blocking of circulation in the vein, which in some patients leads to pain, swelling, tenderness, discolouration of the skin that is warm to touch. Aim of the Work Compare the effect of direct Oral Anticoagulant (Rivaroxaban) versus Antivitamin K (warfarin) in treatment of lower limb Deep Venous Thrombosis. Patients and Methods Type of study: prospective single blinded randomized study, study setting: was conducted at Kobri Elkobba hospitals, study period: 6 months, study population: Eligible all patients above 18 years had femoropopliteal vein thrombosis, confirmed with duplex ultrasound scanning and D-dimer test and qualified under the inclusion and exclusion criteria of the study. Results Our study shows that Rivaroxaban alone is as effective as standard therapy, with similar safety, for the treatment of acute DVT and in preventing recurrence and has low risk of bleeding. There was statistically significant increase in INR monitoring during 6 months in warfarin group than Rivaroxaban group with p-value < 0.001. This because warfarin has many drug and food interaction. There's no response in treatment out come after 3 months duplex as the study was on patient of femoro popliteal DVT, however there were clinical improvement in both groups. Complete recanalization with normal augmentation by muscle compression occurred in all Rivaroxaban patients compared to 5% were partially compressible with incomplete recanalization in warfarin group after 6 months of treatment. Conclusion We concluded in patients with unprovoked VTE, rivaroxaban has the potential to reduce both the risk of major bleeding and recurrent VTE compared to warfarin. And there’s no need for adjusting the dose and INR monitoring, and Rivaroxaban has no food nor drug interactions.

Subclinical Deep Venous Thrombosis Affects 10 % of Haemophiliacs Undergoing Major Orthopaedic Surgery.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3377-3377 ◽  
Author(s):  
Cedric R. Hermans ◽  
Catherine Lambert
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Orthopaedic Surgery ◽  
Ankle Arthrodesis ◽  
Lower Limbs ◽  
Clotting Factor ◽  
Decompressive Laminectomy ◽  
Short Course ◽  
Major Orthopedic Surgery ◽  
Major Orthopaedic Surgery

Abstract The management of venous thromboembolism (VTE) in patients with haemophilia undergoing major orthopaedic surgery requiring intensive replacement therapy remains controversial. Information about the incidence of proven VTE in this setting is lacking. Despite the absence of data, half of haemophilia comprehensive centers in Europe recently reported the use of pharmacological antithrombotic prophylaxis in this setting. We conducted a prospective study to evaluate the occurrence of deep venous thrombosis (DVT) of the lower limbs in all consecutive patients with haemophilia referred for major orthopaedic surgery at the Cliniques universitaires Saint-Luc, Brussels, Belgium. Screening for DVT by unilateral (13) or bilateral (16) compression ultrasonography (US) of the lower limbs was performed 5 to 12 days after 29 major orthopaedic surgeries (total hip replacement (5), total knee replacement (TKR) (15), ankle arthrodesis (4), decompressive laminectomy for lumbar stenosis (1), femoral osteosynthesis (4)) in 22 patients with severe (16), moderate (4) or mild (2) haemophilia A (20) or B (2), intensively treated with continuous infusion of clotting factor concentrate. None of the patients received pharmacological anti-thrombotic prophylaxis with LMWH. There was no case of clinical DVT or pulmonary embolism during the 3-months post-operative clinical surveillance. However distal DVT involving a single peroneal vein without proximal extension was identified in two patients with severe HA after TKR and in one patient with mild HB after decompressive laminectomy. The latter was efficiently treated with a short course of LMWH. The two others resolved spontaneously without antithrombotic therapy. In conclusion, sub-clinical DVT affects up to 10 % of patients with haemophilia undergoing major orthopedic surgery. All thrombotic events were distal and resolved spontaneously or with a short course of LMWH without complications. This study suggests that routine screening for DVT by compressive US is indicated in patients with haemophilia undergoing major orthopaedic surgery and not receiving pharmacological thromboprophylaxis. Further studies are needed to determine if systematic pharmacological prevention of DVT is required in this setting as in patients without haemophilia.

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