scholarly journals Statin use in patients with peripheral arterial disease

2016 ◽  
Vol 64 (6) ◽  
pp. 1881-1888 ◽  
Author(s):  
Sheena K. Harris ◽  
Matt G. Roos ◽  
Gregory J. Landry
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Statin Use

scholarly journals Statin use improves limb salvage after intervention for peripheral arterial disease

2019 ◽  
Vol 70 (2) ◽  
pp. 539-546 ◽  
Author(s):  
Gaurav M. Parmar ◽  
Zdenek Novak ◽  
Emily Spangler ◽  
Mark Patterson ◽  
Marc A. Passman ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Limb Salvage ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Statin Use

Abstract 117: Statin Use Improves Limb Salvage After Intervention for Peripheral Arterial Disease

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Gaurav Parmar ◽  
Zdenek Novak ◽  
Benjamin J Pearce ◽  
Mark A Patterson ◽  
Emily Spangler ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Limb Salvage ◽  
Cox Regression ◽  
Oral Anticoagulants ◽  
Univariate Analysis ◽  
Arterial Disease ◽  
Lower Mortality ◽  
Social Security Death Index ◽  
Peripheral Arterial ◽  
Statin Use

Background: Statin use is recommended in patients with peripheral arterial disease (PAD) due to its morbidity and mortality benefits. However, the effect of statins on limb salvage in PAD is unclear. We examined the effect of statins on survival and limb salvage among PAD patients undergoing surgical or endovascular intervention. Methods: PAD patients were identified who underwent intervention between 2009 and 2010. Information was collected from electronic medical records and the Social Security Death Index. Univariate analysis was used to determine predictors of ongoing statin use. Survival and freedom from amputation were determined using KM plots and adjusted hazard ratios by Cox regression. Results: A total of 488 PAD patients underwent surgical (n=297) or endovascular (n=191) intervention. 39% were African-American, 44% were female, 41% received statins, 56% received antiplatelet medications, 26% received oral anticoagulants, 9% required a major amputation, and 11% died during follow-up of up to 88 months. Statin users were more often male (p=0.03), caucasian (p=0.03), smokers (p<0.01), and had higher comorbidities such as CAD (p<0.01), hypertension (p<0.01), and diabetes (p<0.01). Antiplatelet use was not associated with amputations (p=0.13), but did lower mortality (p<0.01). Dual antiplatelet therapy did not show any benefit over monotherapy for mortality (p=0.3) or amputations (p=0.4). Statin use was associated with lower mortality (p=0.04), and improved limb salvage (hazard ratio, 0.3; 95% confidence interval, 0.2-0.6) after adjusting for severity of disease as well as antiplatelet and anticoagulation use. Conclusion: Statin use in PAD patients with interventions was associated with improved limb-salvage and survival. Despite existing guidelines, statin therapy was disappointingly low in our PAD population, and efforts will be made to increase use across our health system.

scholarly journals Statin Use and Leg Functioning in Patients With and Without Lower-Extremity Peripheral Arterial Disease

Circulation ◽  
2003 ◽  
Vol 107 (5) ◽  
pp. 757-761 ◽  
Author(s):  
Mary McGrae McDermott ◽  
Jack M. Guralnik ◽  
Philip Greenland ◽  
William H. Pearce ◽  
Michael H. Criqui ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Lower Extremity ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Statin Use

scholarly journals Statin Use and Functional Decline in Patients With and Without Peripheral Arterial Disease

2006 ◽  
Vol 47 (5) ◽  
pp. 998-1004 ◽  
Author(s):  
Jay Giri ◽  
Mary M. McDermott ◽  
Philip Greenland ◽  
Jack M. Guralnik ◽  
Michael H. Criqui ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Functional Decline ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Statin Use
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