scholarly journals A potential role for glycated cross-links in abdominal aortic aneurysm disease

2017 ◽  
Vol 65 (5) ◽  
pp. 1493-1503.e3 ◽  
Author(s):  
Dave Koole ◽  
Joost A. van Herwaarden ◽  
Casper G. Schalkwijk ◽  
Floris P.J.G. Lafeber ◽  
Aryan Vink ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Abdominal Aortic ◽  
Cross Links

Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development

2017 ◽  
Vol 131 (22) ◽  
pp. 2707-2719 ◽  
Author(s):  
Carlos-Ernesto Fernandez-García ◽  
Carlos Tarin ◽  
Raquel Roldan-Montero ◽  
Diego Martinez-Lopez ◽  
Monica Torres-Fonseca ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Protein Expression ◽  
Potential Role ◽  
Control Group ◽  
Mrna Levels ◽  
Abdominal Aortic ◽  
Stat3 Phosphorylation ◽  
Galectin 3 ◽  
Mrna And Protein Expression

Abdominal aortic aneurysm (AAA) evolution is unpredictable and no specific treatment exists for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated with CVD, but its potential role in AAA has not been addressed. Galectin-3 levels were increased in the plasma of AAA patients (n=225) compared with the control group (n=100). In addition, galectin-3 concentrations were associated with the need for surgical repair, independently of potential confounding factors. Galectin-3 mRNA and protein expression were increased in human AAA samples compared with healthy aortas. Experimental AAA in mice was induced via aortic elastase perfusion. Mice were treated intravenously with the galectin-3 inhibitor modified citrus pectin (MCP, 10 mg/kg, every other day) or saline. Similar to humans, galectin-3 serum and aortic mRNA levels were also increased in elastase-induced AAA mice compared with control mice. Mice treated with MCP showed decreased aortic dilation, as well as elastin degradation, vascular smooth muscle cell (VSMC) loss, and macrophage content at day 14 postelastase perfusion compared with control mice. The underlying mechanism(s) of the protective effect of MCP was associated with a decrease in galectin-3 and cytokine (mainly CCL5) mRNA and protein expression. Interestingly, galectin-3 induced CCL5 expression by a mechanism involving STAT3 activation in VSMC. Accordingly, MCP treatment decreased STAT3 phosphorylation in elastase-induced AAA. In conclusion, increased galectin-3 levels are associated with AAA progression, while galectin-3 inhibition decreased experimental AAA development. Our data suggest the potential role of galectin-3 as a therapeutic target in AAA.

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

2013 ◽  
Vol 228 (2) ◽  
pp. 295-305 ◽  
Author(s):  
Smriti Murali Krishna ◽  
Anthony Dear ◽  
Jeffrey M. Craig ◽  
Paul E. Norman ◽  
Jonathan Golledge
Keyword(s):  
Dna Methylation ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Epigenetic Changes ◽  
Aneurysm Formation ◽  
Abdominal Aortic

scholarly journals Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Yingying Zhou ◽  
Jiaoni Wang ◽  
Yangjing Xue ◽  
Aili Fang ◽  
Shaoze Wu ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Macrophage Activation ◽  
Potential Role ◽  
Biological Function ◽  
Cascade Reactions ◽  
Fatal Disease ◽  
Abdominal Aortic ◽  
Activated Macrophage

Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA. We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA. We have also demonstrated that macrophage activation plays a key role in Bap-induced AAA, but the mechanism is unknown. Here, we used a mouse lncRNA array to investigate the expression signatures of lncRNAs and mRNAs in Bap-activated macrophage. A total of 457 lncRNAs and 219 mRNAs were found to be differentially expressed. The function of differential mRNAs was determined by pathway and Gene Ontology analysis. Eight pathways associated with inflammation were upregulated, and seven pathways including cell apoptosis were downregulated. It was worth noting that AGE-RAGE pathway, which was involved in Bap-induced EPC dysfunction, was significantly upregulated in Bap-activated macrophage and may contribute to AAA formation. Thus, lncRNAs may exert a key role in activated macrophages and intervene the core lncRNAs and may inhibit the occurrence of a series of cascade reactions in the macrophages, which may provide potential targets for AAA caused by smoking.

The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm

2015 ◽  
Vol 241 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Bradley J. Toghill ◽  
Athanasios Saratzis ◽  
Seamus C. Harrison ◽  
Ana R. Verissimo ◽  
Eamonn B. Mallon ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Abdominal Aortic
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