scholarly journals Gene polymorphism -418 G/C of tissue inhibitor of metalloproteinases 2 is associated with abdominal aortic aneurysm

2015 ◽  
Vol 61 (5) ◽  
pp. 1114-1119 ◽  
Author(s):  
Joanna Mikołajczyk-Stecyna ◽  
Aleksandra Korcz ◽  
Marcin Gabriel ◽  
Katarzyna Pawlaczyk ◽  
Grzegorz Oszkinis ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Gene Polymorphism ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor ◽  
Abdominal Aortic

scholarly journals Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1

2020 ◽  
Vol 40 (12) ◽  
Author(s):  
Huan Yang ◽  
Ting Zhou ◽  
Christine M. Sorenson ◽  
Nader Sheibani ◽  
Bo Liu
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Molecular Mechanisms ◽  
Inflammatory Cells ◽  
Matricellular Protein ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor ◽  
Abdominal Aortic ◽  
Thrombospondin 1 ◽  
Inflammatory Macrophages

Objective: Abdominal aortic aneurysm is characterized by the progressive loss of aortic integrity and accumulation of inflammatory cells primarily macrophages. We previously reported that global deletion of matricellular protein TSP1 (thrombospondin-1) protects mice from aneurysm formation. The objective of the current study is to investigate the cellular and molecular mechanisms underlying TSP1’s action in aneurysm. Approach and Results: Using RNA fluorescent in situ hybridization, we identified macrophages being the major source of TSP1 in human and mouse aneurysmal tissues, accounting for over 70% of cells that actively expressed Thbs1 mRNA. Lack of TSP1 in macrophages decreased solution-based gelatinase activities by elevating TIMP1 (tissue inhibitor of metalloproteinases-1) without affecting the major MMPs (matrix metalloproteinases). Knocking down Timp1 restored the ability of Thbs1 − /− macrophages to invade matrix. Finally, we generated Thbs1 flox/flox mice and crossed them with Lyz2-cre mice. In the CaCl 2 -induced model of abdominal aortic aneurysm, lacking TSP1 in myeloid cells was sufficient to protect mice from aneurysm by reducing macrophage accumulation and preserving aortic integrity. Conclusions: TSP1 contributes to aneurysm pathogenesis, at least in part, by suppressing TIMP1 expression, which subsequently enables inflammatory macrophages to infiltrate vascular tissues.

MMP-13 (−77A>G) gene polymorphism is not a susceptibility factor of abdominal aortic aneurysm or aortoiliac occlusive disease

2012 ◽  
Vol 56 (5-6) ◽  
pp. 379
Author(s):  
Aleksandra Korcz ◽  
Oliwia Zakerska ◽  
Katarzyna Pawlaczyk ◽  
Marta Molinska-Glura ◽  
Grzegorz Oszkinis ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Gene Polymorphism ◽  
Occlusive Disease ◽  
Aortoiliac Occlusive Disease ◽  
Susceptibility Factor ◽  
Abdominal Aortic
Sign in / Sign up

Export Citation Format

Share Document