scholarly journals Factors Associated With Primary Vein Graft Thrombosis in a Multicenter Trial With Mandated Ultrasound Surveillance

2013 ◽  
Vol 57 (1) ◽  
pp. 289-290
Author(s):  
Lawrence B. Oresanya ◽  
Gregory L. Moneta ◽  
Michael Belkin ◽  
Michael S. Conte
Keyword(s):  
Vein Graft ◽  
Multicenter Trial ◽  
Graft Thrombosis ◽  
Primary Vein ◽  
Factors Associated ◽  
Ultrasound Surveillance

scholarly journals Factors associated with primary vein graft occlusion in a multicenter trial with mandated ultrasound surveillance

2014 ◽  
Vol 59 (4) ◽  
pp. 996-1002 ◽  
Author(s):  
Lawrence Oresanya ◽  
Anil N. Makam ◽  
Michael Belkin ◽  
Gregory L. Moneta ◽  
Michael S. Conte
Keyword(s):  
Vein Graft ◽  
Multicenter Trial ◽  
Graft Occlusion ◽  
Primary Vein ◽  
Factors Associated ◽  
Ultrasound Surveillance

Abstract 2213: Characteristics of Aspirin Non-Responders: Results from the Aspirin Resistance Testing and Initial Strategy for Treatment (ARTIST) Multicenter Trial

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Lori B Daniels ◽  
Paul Clopton ◽  
W. F Peacock ◽  
Richard Nowak ◽  
Alex Harrison ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Multicenter Trial ◽  
Aspirin Resistance ◽  
Resistance Testing ◽  
Lower Prevalence ◽  
Therapeutic Implications ◽  
Factors Associated ◽  
Coronary Syndrome ◽  
Initial Strategy ◽  
History Of

Introduction: Aspirin (ASA) therapy reduces the risk of thrombotic events by inhibiting platelet aggregation, however some individuals have a diminished response to ASA. The ability to predict ASA non-responsiveness has important therapeutic implications. We studied patients with suspected acute coronary syndrome (ACS) to determine the characteristics of patients with ASA non-responsiveness. Methods: We enrolled 1010 patients with suspected ACS in the emergency departments (ED’s) of 5 sites. All subjects were on outpatient ASA therapy or received ASA in the ED, and were excluded if on clopidogrel. Blood was tested for ASA non-responsiveness (defined as ASA reactive units ≥ 550) on a VerifyNow® (Accumetrics) device. Results: Overall prevalence of ASA non-responsiveness was 10.3% (95% C.I. 8.6–12.3%). Responsiveness to ASA did not differ by age or sex, but varied significantly by race. Hispanics had a higher prevalence of ASA non-responsiveness, while whites and Asians had a lower prevalence ( Figure ). Other factors associated with increased prevalence of ASA resistance included outpatient ASA therapy (p<0.001), a history of alcohol (p=0.045) or drug abuse (p=0.02), a history of heart failure (p=0.01), and renal insufficiency (p=0.003). Patients with ASA non-responsiveness had lower BMI (p=0.006) and hemoglobin (p<0.001), and higher BNP levels (p<0.001), prothrombin time (p=0.01), and partial thromboplastin time (p<0.001). Conclusions: Among suspected ACS patients, the prevalence of ASA non-responsiveness varies by race and is highest in Hispanics. ASA resistance is also more prevalent in patients with clinical characteristics consistent with poorer health. Prevalence of ASA Non-Responsiveness by Race

Role of Aspirin Resistance, Mechanical Factors and Inflammation on Early Saphenous Vein Graft Thrombosis After CABG

2021 ◽  
Author(s):  
Dudy Arman hanafy ◽  
Budhi Setianto Setianto ◽  
Jusuf Rachmat ◽  
Soesanto ◽  
Arman Adel Abdullah ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Vein Graft ◽  
Graft Failure ◽  
Saphenous Vein Graft ◽  
Aspirin Resistance ◽  
Primary Role ◽  
Flow Measurements ◽  
Graft Thrombosis ◽  
Mechanical Factors

Abstract Objectives: This study was carried out to determine the role of pre-operative and transient aspirin resistance in the formation of early saphenous vein graft (SVG) thrombosis six weeks after coronary artery bypass graft (CABG) surgery and to analyze the other factors, such as mechanical and inflammation factors, that are also suspected of contributing to the formation of early thrombosis.Methods: Pre- and post-operative blood samples were taken from 99 subjects, whom 74 patients were undergoing elective on-pump CABG and receiving aspirin as monotherapy, for evaluation of inflammation parameters and the state of aspirin resistance using a Platelet Function Analyzer-200 (PFA-200). Transit time flow measurements (TTFM) were performed intra-operatively to determine mechanical factors. Multi-sliced computed tomography (MSCT) was done six weeks after surgery to determine the patency of the vein grafts.Result: In the 222 vein conduits, aspirin resistance was related to early vein graft failure due to thrombosis (p < 0.001; relative risk (RR) = 3.69). The massive increase of interleukin 6 (IL-6) levels after surgery were related to the existence of post-operative transient aspirin resistance (p < 0.001). Transient aspirin resistance (IL-6 > 122.5) was associated with early graft failure (p = 0.029; RR = 8.6) compared to the aspirin-sensitive group (IL-6 > 122.5).Conclusion: Aspirin resistance plays a primary role in early vein graft thrombosis. Transient aspirin resistance accompanied by an increase of inflammation factor (IL-6) significantly increases the risk of early vein graft thrombosis after CABG.

Diffuse saphenous vein graft thrombosis

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Stephen D. Dickson ◽  
Adam Taleb ◽  
Szymon Wiernek ◽  
Alayn Govea ◽  
William Penny
Keyword(s):  
Saphenous Vein ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Graft Thrombosis

scholarly journals Identification of factors predictive of lower extremity vein graft thrombosis

2001 ◽  
Vol 33 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Kathleen D. Gibson ◽  
Michael T. Caps ◽  
Daniel Gillen ◽  
Robert O. Bergelin ◽  
Jean Primozich ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Vein Graft ◽  
Graft Thrombosis

scholarly journals Rivaroxaban for the treatment of saphenous vein graft thrombosis

2016 ◽  
Vol 35 (7-8) ◽  
pp. 447.e1-447.e3
Author(s):  
Konstantinos Marmagkiolis ◽  
Mehmet Cilingiroglu
Keyword(s):  
Saphenous Vein ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Graft Thrombosis

scholarly journals Technical factors affecting autogenous vein graft failure: Observations from a large multicenter trial

2007 ◽  
Vol 46 (6) ◽  
pp. 1180-1190 ◽  
Author(s):  
Andres Schanzer ◽  
Nathanael Hevelone ◽  
Christopher D. Owens ◽  
Michael Belkin ◽  
Dennis F. Bandyk ◽  
...  
Keyword(s):  
Vein Graft ◽  
Graft Failure ◽  
Multicenter Trial ◽  
Factors Affecting ◽  
Autogenous Vein ◽  
Technical Factors ◽  
Vein Graft Failure

scholarly journals The cerebral function monitor (CFM) is a useful addition to a bilateral carotid artery, vein graft model

1995 ◽  
Vol 29 (4) ◽  
pp. 427-431 ◽  
Author(s):  
C. C. Toner ◽  
M. J. Underwood ◽  
S. J. Wright ◽  
G. J. Cooper ◽  
P. Reynolds ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Vein Graft ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Neurological Complications ◽  
Graft Occlusion ◽  
Cerebral Function ◽  
Human Coronary Artery ◽  
Graft Thrombosis ◽  
Bilateral Carotid

Following human coronary artery bypass surgery, vein graft occlusion is a major cause of morbidity and mortality. An agent is required which will reduce the incidence of early graft thrombosis without causing systemic bleeding. To assess the efficacy of such agents a suitable experimental vein-graft model is required. A porcine, unilateral saphenous vein-carotid artery bypass graft model has been described previously, although to assess the effect of locally applied anticoagulant drugs, insertion of grafts bilaterally would be advantageous, allowing treated and control grafts to be implanted in the same animal which would then act as its own control. Pigs are reported as having an excellent collateral cerebral circulation and hence in theory, would be suitable animals to use as a bilateral carotid vein-graft model. This paper describes the occurrence of serious neurological complications during the development of such a model and suggests that by using a cerebral function monitor, detection of critical reductions in cerebral perfusion can be made early and remedial action take.

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