scholarly journals Toward a mouse model of hind limb ischemia to test therapeutic angiogenesis

2012 ◽  
Vol 56 (6) ◽  
pp. 1669-1679 ◽  
Author(s):  
Robert A. Brenes ◽  
Caroline C. Jadlowiec ◽  
Mackenzie Bear ◽  
Peter Hashim ◽  
Clinton D. Protack ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Hind Limb Ischemia

scholarly journals SS5. SVS Foundation Resident Research Prize Winner A Novel Mouse Model of Hind Limb Ischemia to Test Therapeutic Angiogenesis

2012 ◽  
Vol 55 (6) ◽  
pp. 18S-19S
Author(s):  
Robert Brenes ◽  
Caroline C. Jadlowiec ◽  
Mackenzie Bear ◽  
Peter Hashim ◽  
Clinton D. Protack ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Hind Limb Ischemia ◽  
Resident Research

Placenta-derived PLX-PAD mesenchymal-like stromal cells are efficacious in rescuing blood flow in hind limb ischemia mouse model by a dose- and site-dependent mechanism of action

Cytotherapy ◽  
2017 ◽  
Vol 19 (12) ◽  
pp. 1438-1446 ◽  
Author(s):  
Efrat Zahavi-Goldstein ◽  
Michal Blumenfeld ◽  
Dana Fuchs-Telem ◽  
Lena Pinzur ◽  
Shy Rubin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mouse Model ◽  
Mechanism Of Action ◽  
Stromal Cells ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Hind Limb Ischemia ◽  
Dependent Mechanism

Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

2009 ◽  
Vol 4 (12) ◽  
pp. 1737-1748 ◽  
Author(s):  
Anne Limbourg ◽  
Thomas Korff ◽  
L Christian Napp ◽  
Wolfgang Schaper ◽  
Helmut Drexler ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

A novel model of hind limb ischemia to test human therapeutic angiogenesis

2011 ◽  
Vol 213 (3) ◽  
pp. S101-S102
Author(s):  
Robert A. Brenes ◽  
Mackenzie Bear ◽  
Caroline Jadlowiec ◽  
Peter Hashim ◽  
Juan A. Sanchez ◽  
...  
Keyword(s):  
Hind Limb ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Hind Limb Ischemia ◽  
Novel Model

Call for a reference model of chronic hind limb ischemia to investigate therapeutic angiogenesis

2009 ◽  
Vol 51 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Zijiang Yang ◽  
Moritz Wyler von Ballmoos ◽  
Nicolas Diehm ◽  
Iris Baumgartner ◽  
Christoph Kalka ◽  
...  
Keyword(s):  
Hind Limb ◽  
Reference Model ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Hind Limb Ischemia

scholarly journals CHRONIC STRESS ACCELERATES AGING INDUCED COLLATERAL DYSFUNCTION IN C57BL6 MOUSE MODEL OF HIND LIMB ISCHEMIA

2013 ◽  
Vol 61 (10) ◽  
pp. E2090
Author(s):  
Sunny Jhamnani ◽  
Roberta Lassance–Soares ◽  
Subeena Sood ◽  
Nima Aghili ◽  
Hajra Nashin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Chronic Stress ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Hind Limb Ischemia ◽  
C57bl6 Mouse

scholarly journals Imaging receptor for advanced glycation end product expression in mouse model of hind limb ischemia

2013 ◽  
Vol 3 (1) ◽  
pp. 37 ◽  
Author(s):  
Yared Tekabe ◽  
Maria Kollaros ◽  
Chong Li ◽  
Geping Zhang ◽  
Ann Schmidt ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Advanced Glycation ◽  
Hind Limb Ischemia ◽  
Advanced Glycation End Product ◽  
Product Expression

scholarly journals Resveratrol Promotes Angiogenesis in a FoxO1-Dependent Manner in Hind Limb Ischemia in Mice

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7528
Author(s):  
Dongxiao Fan ◽  
Chenshu Liu ◽  
Zeling Guo ◽  
Kan Huang ◽  
Meixiu Peng ◽  
...  
Keyword(s):  
Hind Limb ◽  
Umbilical Vein ◽  
Oral Intake ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Severe Form ◽  
Dependent Manner ◽  
Protective Effects ◽  
Hind Limb Ischemia ◽  
Beneficial Effects

Critical limb ischemia (CLI) is a severe form of peripheral artery diseases (PAD) and seriously endangers the health of people. Therapeutic angiogenesis represents an important treatment strategy for CLI; various methods have been applied to enhance collateral circulation. However, the current development drug therapy to promote angiogenesis is limited. Resveratrol (RSV), a polyphenol compound extracted from plants, has various properties such as anti-oxidative, anti-inflammatory and anti-cancer effects. Whether RSV exerts protective effects on CLI remains elusive. In the current study, we demonstrated that oral intake of RSV significantly improved hind limb ischemia in mice, and increased the expression of phosphorylated Forkhead box class-O1 (FoxO1). RSV treatment in human umbilical vein endothelial cells (HUVECs) could increase the phosphorylation of FoxO1 and its cytoplasmic re-localization to promote angiogenesis. Then we manipulated FoxO1 in HUVECs to further verify that the effect of RSV on angiogenesis is in a FoxO1-dependent manner. Furthermore, we performed metabolomics to screen the metabolic pathways altered upon RSV intervention. We found that the pathways of pyrimidine metabolism, purine metabolism, as well as alanine, aspartate and glutamate metabolism, were highly correlated with the beneficial effects of RSV on the ischemic muscle. This study provides a novel direction for the medical therapy to CLI.

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