scholarly journals SS34. Clinical Research Review Anticoagulation for Calf Deep Venous Thrombosis: A Systematic Review and Meta-Analysis

2011 ◽  
Vol 53 (6) ◽  
pp. 104S-105S ◽  
Author(s):  
Randall R. De Martino ◽  
Jessica B. Wallaert ◽  
Ana P. Rossi ◽  
Alicia J. Zbehlik ◽  
Daniel B. Walsh
2014 ◽  
Vol 30 (3) ◽  
pp. 406-412 ◽  
Author(s):  
Ye Sun ◽  
Dongyang Chen ◽  
Zhihong Xu ◽  
Dongquan Shi ◽  
Jin Dai ◽  
...  

2019 ◽  
Vol 7 (2) ◽  
pp. 272-276
Author(s):  
Gregory Eckenrode ◽  
Becky Baltich Nelson ◽  
Andre Belarmino ◽  
Stephanie Ashley Chen ◽  
Shokhi Goel ◽  
...  

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Noman Shahzad ◽  
Asad Moosa ◽  
Fareed Shaikh ◽  
Nadeem Siddiqui ◽  
Jan Macierewicz

Abstract Optimal management of isolated peripheral deep venous injuries remain controversial with no clear evidence based guidelines on repair vs ligation. We aimed to compare the morbidity and mortality after venous reconstruction versus ligation of isolated peripheral venous injuries in patients with trauma. Methods We conducted systematic review and meta-analysis of all literature reported on management of isolated vascular injuries in adult trauma patients excluding case reports from 1950 to 2020. Primary outcomes of interest were mortality and amputation while secondary outcomes of interest were compartment syndrome, chronic venous hypertension, deep venous thrombosis and pulmonary embolism. Pubmed, Google Scholar, Cochrane database and Web of Science were searched for relevant literature. Study selection and sysnthesis was done following PRSMA Guidelines. Protocol was registered with PRSPERO (Registration Number: CRD42019143136). Results A total of 25 studies met our selection criteria and reported at least one of outcomes of interest. All the data is from observational studies with mostly retrospective data collection. Results of our meta-analysis show that ligation is significantly associated with higher rate of amputations [OR: 1.73 (1.20 – 2.48), p = 0.003] and mortality [OR: 1.5 (1.09 – 2.06), p = 0.01] whereas there is no significant difference in rate of chronic venous insufficiency, deep venous thrombosis and pulmonary embolism. There is not sufficient data to analyze various types of repair. Also data is lacking to account for clinical severity at time of presentation. Conclusion Our results favor repair over ligation of isolated peripheral deep venous injury.


VASA ◽  
2016 ◽  
Vol 45 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Jakob Martin Burgstaller ◽  
Johann Steurer ◽  
Ulrike Held ◽  
Beatrice Amann-Vesti

Abstract. Background: Here, we update an earlier systematic review on the preventive efficacy of active compression stockings in patients with diagnosed proximal deep venous thrombosis (DVT) by including the results of recently published trials. The aims are to synthesize the results of the original studies, and to identify details to explain heterogeneous results. Methods: We searched the Cochrane Library, PubMed, Scopus, and Medline for original studies that compared the preventive efficacy of active compression stockings with placebo or no compression stockings in patients with diagnosed proximal DVT. Only randomized controlled trials (RCTs) were included. Results: Five eligible RCTs with a total of 1393 patients (sample sizes ranged from 47 to 803 patients) were included. In three RCTs, patients started to wear compression stockings, placebo stockings or no stockings within the first three weeks after the diagnosis of DVT. The results of two RCTs indicate a statistically significant reduction in post-thrombotic syndrome (PTS) of 50% or more after two or more years. The result of one RCT shows no preventive effect of compression stockings at all. Due to the heterogeneity of the study results, we refrained from pooling the results of the RCTs. In a further RCT, randomization to groups with and without compression stockings took place six months after the diagnosis of DVT, and in another RCT, only patients with the absence of PTS one year after the diagnosis of DVT were analyzed. One RCT revealed a significant reduction in symptoms, whereas another RCT failed to show any benefit of using compression stockings. Conclusions: At this time, it does not seem to be justifiable to entirely abandon the recommendations regarding compression stockings to prevent PTS in patients with DVT. There is evidence favoring compression stockings, but there is also evidence showing no benefit of compression stockings.


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